Plasma levels of progesterone and oestrogen in the pregnant guinea-pig

Dv, Illingworth; Challis,; Henville, A.

doi:10.1530/jrf.0.0250305

Cited by 7 publications

(4 citation statements)

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“…This pattern differs from that reported in ewes (Bassett, Oxborrow, Smith & Thorburn, 1969 ;Fylling, 1970), where during the same period of gestation there was a 200-500 % increase in progesterone levels in peripheral plasma. Even greater increases during pregnancy have been reported in guinea-pigs (Heap & Deanesly, 1966;Illingworth, Challis & Henville, 1971) and in women (Short, 1961 ;Greig, Coyle, Cooper & Walker, 1962). However, in these species with a marked increase in plasma progesterone concentration during pregnancy, the placenta also secretes the hormone.…”

Section: Discussionmentioning

confidence: 91%

Progesterone Concentration in the Peripheral Plasma of Pregnant Goats

Irving¹,

Da²,

Knifton³

1972

Journal of Endocrinology

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Plasma progesterone concentration was measured by a competitive protein-binding method in serial samples of jugular venous blood from 21 pregnant goats, 11 with twin and 10 with single foetuses.Progesterone levels in twin pregnancies were significantly greater than in singletons. The mean progesterone concentration (ng/ml plasma) in the twin pregnancies was greatest during the 3rd month of gestation (10\m=.\7 \ m=+-\0\m=.\4 (s.e.m.)) and in the singletons during the 4th month (7\m=.\8 \ m=+-\ 0\m=.\2 (s.e.m.)). There was a significant decrease in mean progesterone concentration in the last month of pregnancy due to a steady decline in the last 7 days before parturition.The mean progesterone concentrations at parturition in five twin and eight single pregnancies were 2\m=.\2\ m=+-\0\m=.\4and 1\m=.\5\ m=+-\0\m=.\2 (s.e.m.) ng/ml plasma respectively; there was no significant difference between these values. In cord blood from nine kids immediately after delivery the progesterone concentration was 0\m=.\9\ m=+-\0\m=.\1 ng/ml.

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Section: Discussionmentioning

confidence: 91%

Progesterone Concentration in the Peripheral Plasma of Pregnant Goats

Irving¹,

Da²,

Knifton³

1972

Journal of Endocrinology

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“…; Illingworth et al . ; Mitchell & Taggart, ). This contrasts with most other laboratory species, including mice, rats and sheep (Fig.…”

Section: Introductionmentioning

confidence: 99%

Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

Morrison

Botting

Darby

et al. 2018

The Journal of Physiology

116

108

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Over 30 years ago Professor David Barker first proposed the theory that events in early life could explain an individual's risk of non-communicable disease in later life: the developmental origins of health and disease (DOHaD) hypothesis. During the 1990s the validity of the DOHaD hypothesis was extensively tested in a number of human populations and the mechanisms underpinning it characterised in a range of experimental animal models. Over the past decade, researchers have sought to use this mechanistic understanding of DOHaD to develop therapeutic interventions during pregnancy and early life to improve adult health. A variety of animal models have been used to develop and evaluate interventions, each with strengths and limitations. It is becoming apparent that effective translational research requires that the animal paradigm selected mirrors the tempo of human fetal growth and development as closely as possible so that the effect of a perinatal insult and/or therapeutic intervention can be fully assessed. The guinea pig is one such animal model that over the past two decades has demonstrated itself to be a very useful platform for these important reproductive studies. This review highlights similarities in the in utero development between humans and guinea pigs, the strengths and limitations of the guinea pig as an experimental model of DOHaD and the guinea pig's potential to enhance clinical therapeutic innovation to improve human health.

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“…Moreover, different from the situation in species with a prepartal progesterone withdrawal initiating rather single-stranded chains of events, in humans it has been suggested that the onset of birth results from a protracted parallel destabilization of pregnancy in several compartments of the fetal-placental-maternal unit synergizing in the transformation of the uterus from a quiescent to a contractile phenotype (modular accumulation of physiological systems; Mitchell and Taggart, 2009). Similar to the situation in humans, also in guinea pigs parturition occurs in the presence of high progesterone levels of placental origin (Illingworth et al, 1971). It is evident that a broad variety of placental signaling molecules participates in the feto-maternal dialogue during the period between the initiation of parturition and the timely release of the placenta, including numerous locally acting factors (Streyl et al, 2012).…”

Section: The Initiation Of Parturition: the Placenta As A Target And mentioning

confidence: 98%

Placental contribution to the endocrinology of gestation and parturition

Schuler¹,

Fürbaß²,

Klisch

2018

Anim Reprod

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In addition to many other functions, the placenta is a source of a vast number of autocrine, paracrine and endocrine factors. However, the spectrum of placental regulatory factors, their concentrations, gestational profiles and roles may differ considerably even between phylogenetically closely related species. Depending on the species, placental regulatory factors of a broad range of molecule classes have been found including (glyco-)proteins, peptides, steroids and prostaglandins. Local placental regulatory factors are especially important for the dialogue between the fetal and the maternal compartment immediately at the feto-maternal borderline and for the control of growth, differentiation and functions of the placenta itself. Moreover, placental hormones in a proper sense may also have effects in more remote targets within the maternal compartment, serving functions such as pregnancy-specific adaptations of maternal circulation, provision of hemotrophe to the fetus or the development and function of the mammary gland. Functions of placental hormones in the fetus proper are less clear but may be especially important before the establishment of a functional fetal endocrine system and near term within the highly species-specific networks of signals preparing and initiating parturition. This review takes a comparative view on the situation in different domestic animals focusing on ruminants and on placental hormones occurring at significant concentrations in the maternal circulation.

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Plasma levels of progesterone and oestrogen in the pregnant guinea-pig

Cited by 7 publications

References 0 publications

Progesterone Concentration in the Peripheral Plasma of Pregnant Goats

Progesterone Concentration in the Peripheral Plasma of Pregnant Goats

Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

Placental contribution to the endocrinology of gestation and parturition

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