Plasma levels of methylprednisolone following administration during cardiac surgery

Thompson, M. A.; Broadbent, M. P.; English, J.

doi:10.1111/j.1365-2044.1982.tb01149.x

Cited by 14 publications

(1 citation statement)

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“…Elowcver, given to normal subjects, the drug has been found to increase HR (31). T h e present observations suggest that the direct effect of glucocorticoids, also at concentrations that are within the range of clinical use, is a slowing of heart rate (32).…”

Section: Discussionsupporting

confidence: 48%

Bell–shaped concentration–response curve for myocardial stimulation by glucocorticoids

Sellevold

Jynge

1989

Acta Anaesthesiol Scand

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The isolated perfused rat heart was used to study the myocardial effects of glucocorticoid methylprednisolone sodium succinate (MPSS 0, 100, 500 and 1000 mg/l) in normoxic conditions. Various physiological variables including coronary flow rate (CFR), left ventricular developed pressure (LVDP), dP/dTmax, dP/dTmin and heart rate (HR) were assessed. At the end of the perfusion period the hearts were freeze clamped and analyzed for tissue content of calcium and various metabolites. MPSS (500 mg/l) resulted in vasodilatation and inotropic stimulation. An increase was found in CFR (+17% +/- 4), LVDP (+6% +/- 1), dP/dTmax (+13% +/- 2), dP/dTmin (+9% +/- 3); (P less than 0.05). Heart rate was depressed (-14% +/- 2, P less than 0.05). MPSS (100 mg/l) had no effect on CFR or contractility. MPSS (1000 mg/l) resulted in a transient vasodilatation and a progressive myocardial depression. MPSS perfusion (100 and 500 mg/l) increased the adenine nucleotide pool and at all concentrations MPSS elevated the myocardial content of lactate. We conclude that in normoxic conditions there is a bell-shaped curve of myocardial inotropic stimulation by the glucocorticoid hormone, and also a stimulation of metabolism possibly by increased cellular supply of substrates.

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Section: Discussionsupporting

confidence: 48%