Plasma levels of matrix metalloproteinase 9 in patients undergoing off-pump coronary artery bypass grafting

Abstract

Our study first established a connection between MMP9 and OPCAB procedure, suggesting that MMP9 could be a novel biomarker for identifying perioperative myocardial injury in patients undergoing OPCAB.

Plasma MMP-9 and TIMP-1 levels on ICU admission are associated with 30-day survival

“…supporting MMP‑9 as an early stage biomarker of poor outcome in cardiovascular disease potentially reflecting atherosclerotic plaque rupture and myocardial tissue destruction [ 49 ]. The MMP‑9 levels further correlate with left ventricular ejection fraction and were associated with perioperative myocardial injury in coronary bypass grafting [ 48 ], which was an underlying diagnosis in some of our patients. To our knowledge, this is the largest published study to date, demonstrating the prognostic value of MMP‑9 levels in a heterogeneous group of critically ill patients admitted to intensive care.…”

Relationship of Gelatynase B Enzyme Activity and Coronary Artery Disease

“…Wang et al [13] have reported that serum gelatinase B level may be a significant biomarker [13]. Recent studies, researchers have reported that gelatinase B could be a novel biomarker for CAD [10,12]. Also İn our previous study, serum gelatinase B enzyme levels were higher in patients compared to controls [19].…”

“…Gelatinase B (also known as MMP-9 and 92-kDa type IV collagenase), one of the MMP family, is highly expressed in the vulnerable regions of the atherosclerotic plaque. Gelatinase B enzymatically active in atherosclerotic plaques, and are known to be associated with the progression and development of atherosclerotic lesions [9][10][11][12]. Studies have reported that gelatinase B associated with coronary artery disease [10,[13][14][15][16][17].…”

“…Gelatinase B enzymatically active in atherosclerotic plaques, and are known to be associated with the progression and development of atherosclerotic lesions [9][10][11][12]. Studies have reported that gelatinase B associated with coronary artery disease [10,[13][14][15][16][17]. Coronary artery disease, can be prevented or significantly delayed, has been reported to be a disease [18].…”

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“…Gelatinase B (also known as MMP-9 and 92-kDa type IV collagenase), one of the MMP family, is highly expressed in the vulnerable regions of the atherosclerotic plaque. Gelatinase B enzymatically active in atherosclerotic plaques, and are known to be associated with the progression and development of atherosclerotic lesions [9][10][11][12]. Studies have reported that gelatinase B associated with coronary artery disease [10,[13][14][15][16][17].…”