Plasma levels of IL-6 correlate with hemodynamic abnormalities in acute pancreatitis in rabbits

Jambrik, Zoltán; Gyöngyösi, Mariann; Hegyi, Péter; Czakó, László; Takács, Tamás; Farkas, András; Mándy, Y.; Góg, Csaba; Glogar, Dietmar; Csanády, Miklós

doi:10.1007/s00134-002-1531-z

Cited by 20 publications

(14 citation statements)

References 38 publications

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“…In this study, the baseline plasma level of IL-6 is slightly higher than in other studies 32 33. Since the results were consistent in all animals in each group, the elevation may be due to a higher sensitivity of the ELISA kit we used compared to that used by others.…”

Section: Discussioncontrasting

confidence: 44%

Anti-Inflammatory Effects of Simvastatin during the Resolution Phase of Experimentally Formed Venous Thrombi

Feng

Lei

Zhang

et al. 2017

Journal of Investigative Medicine

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Deep venous thrombosis (DVT) is a common vascular disease and is closely linked to inflammation. Over the past decade, the potential antithrombotic effect of statins has been elucidated by clinical studies, primarily through focusing on DVT prevention. The effects of statins on DVT resolution and its underlying mechanisms have been rarely addressed. We established a rabbit model of the (IVC) venous thrombosis. After 48 hours, the rabbits were treated with saline, heparin, simvastatin, or simvastatin combined with heparin, respectively, for 14 days. The migration of inflammatory cells (neutrophils, monocytes, lymphocytes) in the thrombi and injured venous wall, the plasma levels of interleukin (IL)-6, monocyte chemotactic protein 1 (MCP-1) and P-selectin, and local expression of MCP-1 and P-selectin in the venous wall were evaluated by histology, immunohistochemistry, and ELISA examinations. Our data showed that compared with saline and heparin controls, monotherapy of simvastatin and the adjunctive therapy with simvastatin and heparin significantly improved the thrombus resolution and reduced inflammatory cells migration into the venous wall, the release of the inflammatory cell adhesion molecule (P-selectin), inflammatory chemokine (MCP-1) and pleiotropic proinflammatory cytokines (IL-6) into the blood, and the local expression of P-selectin and MCP-1 in the venous wall. Simvastatin targets anti-inflammatory pathways during the resolution phase of a thrombus, providing a therapeutic potential in DVT resolution and post-thrombotic syndrome prevention.

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Section: Discussioncontrasting

confidence: 44%

Anti-Inflammatory Effects of Simvastatin during the Resolution Phase of Experimentally Formed Venous Thrombi

Feng

Lei

Zhang

et al. 2017

Journal of Investigative Medicine

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“…Consistent with these findings, the present findings also indicate that the elevated circulating levels of IL-6 after trauma-hemorrhage were significantly reduced by androstenediol treatment. Because elevated levels of IL-6 have been correlated with cardiac dysfunction in many injury conditions (14,22) as well as after trauma-hemorrhage (17,19,25), it is likely that attenuation of IL-6 production could be a factor responsible for androstenediol salutary effect in preventing cardiac dysfunction after trauma-hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Salutary effects of androstenediol on cardiac function and splanchnic perfusion after trauma-hemorrhage

Shimizu

Choudhry

Szalay

et al. 2004

American Journal of Physiology-Regulatory, Integrative and Comp

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-Recent studies have shown that dehydroepiandrosterone (DHEA) administration after trauma-hemorrhage (T-H) improves cardiovascular function and decreases cytokine production in male animals. Although androstenediol, one of the metabolites of DHEA, is reported to have estrogen-like activity, it remains unknown whether androstenediol per se has any salutary effects on cytokines and cardiovascular function after T-H. To examine this effect, male Sprague-Dawley rats underwent laparotomy and were bled to and maintained at a mean arterial blood pressure of 35-40 mmHg for ϳ90 min. The animals were resuscitated with four times the volume of maximal bleedout volume in the form of Ringer lactate. Androstenediol (1 mg/kg body wt iv) or vehicle was administered at the end of resuscitation. Twenty-four hours after resuscitation, cardiac function and organ blood flow were measured by using 85 Sr-microspheres. Circulating levels of nitrate/nitrite and IL-6 were also determined. Cardiovascular function and organ blood flow were significantly depressed after T-H. However, these parameters were restored by androstenediol treatment. The elevated plasma IL-6 levels after T-H were also lowered by androstenediol treatment. In contrast, plasma levels of nitrate/nitrite were the highest in the androstenedioltreated T-H animals. Because androstenediol administration after T-H decreases cytokine production and improves cardiovascular function, this agent appears to be a novel and useful adjunct for restoring the depressed cardiovascular function and for cytokine production in males after adverse circulatory conditions. hemorrhagic shock; nitric oxide; nitric oxide synthase; adiol; 5-androstene-3␤,17␤-diol HEMORRHAGIC SHOCK results in a rapid decrease in cardiac output and organ blood flow. Furthermore, studies have shown that intestinal perfusion remains depressed even after the recovery of cardiac output by fluid resuscitation (29). This splanchnic hypoperfusion after hemorrhagic shock also activates the inflammatory cascade. The depressed cardiovascular function and excess production of inflammatory mediators play an important role in the development of multiple organ failure after hemorrhagic shock (20).Previous work from our laboratory has shown that left ventricular performance, cardiac output, and organ blood flow in the liver, small intestine, and kidney decreased significantly after trauma-hemorrhage (3,4,25), and plasma levels of IL-6

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“…It is also produced by periacinar myofi broblasts in response to TNF-␣ and IL-1 ␤ [71] . IL-6 levels are raised in a number of acute conditions such as burns, major surgery, and sepsis.…”

Section: Il-6mentioning

confidence: 99%

Pathophysiology of acute pancreatitis

et al. 2005

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Plasma levels of IL-6 correlate with hemodynamic abnormalities in acute pancreatitis in rabbits

Abstract: Plasma levels of IL-6, but not TNFalpha correlate with cardiac output and left ventricular filling characteristics in acute pancreatitis. Somatostatin pretreatment improves the cardiac and hemodynamic changes, probably through the decrease in cytokine release.

Cited by 20 publications

References 38 publications

Anti-Inflammatory Effects of Simvastatin during the Resolution Phase of Experimentally Formed Venous Thrombi

Anti-Inflammatory Effects of Simvastatin during the Resolution Phase of Experimentally Formed Venous Thrombi

Salutary effects of androstenediol on cardiac function and splanchnic perfusion after trauma-hemorrhage

Pathophysiology of acute pancreatitis

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