Plasma levels of free tissue factor pathway inhibitor in patients with various thyroid disorders

Özcan, Mehmet Ali; Çömlekçi, Abdurrahman; Demırkan, Fatih; Yüksel, Faize; Sarı, İ̇smail; Demir, Tevfik; Özsan, Güner Hayri; Örük, Gonca; Yeşil, Sena; Ündar, Bülent

doi:10.1016/s0049-3848(03)00408-0

Cited by 23 publications

(50 citation statements)

References 26 publications

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“…In this study, we found that PAI-1 antigen levels were elevated in patients with hyperthyroidism, similar to other studies [10,20]. However, plasma TAFI antigen levels were decreased in hyperthyroid patients.…”

Section: Discussionsupporting

confidence: 92%

“…Similarly, increased levels of PAI-1 antigen have been reported in patients with both thyroid dysfunctions [20,22]. Results from the few studies evaluating PAI-1 levels in hyperthyroid patients suggest that PAI-1 is elevated in hyperthyroidism [8][9][10]20]. We found lower TAFI and elevated PAI-1 antigen levels in patients with hyperthyroidism.…”

Section: Discussionsupporting

confidence: 77%

“…Li et al [9] reported that serum thyroid hormone concentrations were strongly correlated with plasma PAI-1. Ozcan et al [10] found that elevated PAI-1 antigen levels in hyperthyroid patients decreased after euthyroidism was restored.…”

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confidence: 99%

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Thrombin Activatable Fibrinolysis Inhibitor Antigen Levels Are Inversely Correlated with Plasminogen Activator Inhibitor-1 Antigen Levels in Hyperthyroid Patients

et al. 2007

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Abstract. Both increased and decreased fibrinolytic activity have been reported in patients with hyperthyroidism. Elevated levels of plasma plasminogen activator inhibitor-1 (PAI-1) antigen have been found in hyperthyroid patients. Thrombin activatable fibrinolysis inhibitor (TAFI) is a novel plasma protein, which inhibits fibrinolysis through removal of C-terminal lysines from partially degraded fibrin. Previously, we showed that plasma TAFI antigen levels were increased in patients with overt and subclinical hypothyroidism. The aim of this study is to investigate plasma levels of TAFI and PAI-1 antigens in hyperthyroid patients. PAI-1 and TAFI antigen levels were measured in the plasma of 29 patients with hyperthyroidism (14 overt hyperthyroid and 15 subclinical hyperthyroid), and 26 healthy individuals. Although there were increased levels of PAI-1 antigen in hyperthyroid patients, plasma TAFI antigen levels were significantly lower compared to controls (80.79 ng/ml vs. 32.42 ng/ml, p = 0.000 for PAI-1; 10.42 µg/ml vs. 12.24 µg/ml, p = 0.009 for TAFI). Elevated PAI-1 antigen levels were positively correlated with free thyroid hormones, although TAFI antigen levels were in negative correlation with free thyroxine. Furthermore, an inverse correlation between PAI-1 and TAFI antigen levels was found. Our study demonstrated that TAFI antigen levels were decreased in patients with hyperthyroidism. Inverse correlation with PAI-1 suggests that the decrease in TAFI antigen levels may be due to activation of TAFI pathway. Further studies evaluating the underlying mechanisms of low TAFI antigen levels in hyperthyroidism should be undertaken.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 77%

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Thrombin Activatable Fibrinolysis Inhibitor Antigen Levels Are Inversely Correlated with Plasminogen Activator Inhibitor-1 Antigen Levels in Hyperthyroid Patients

et al. 2007

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“…higher levels of alpha 2-antiplasmin, t-PA, and PAI-1 and lower D-dimer) was found in subclinical hypothyroidism. Other small case-control studies confirmed the presence of hypofibrinolysis in patients with subclinical hypothyroidism (8, 36,37), further supporting the possibility that this condition might be associated with increased risk of cardiovascular disease (38).…”

Section: Hypothyroidismmentioning

confidence: 77%

Hemostatic abnormalities in endocrine and metabolic disorders

Franchini¹,

Lippi²,

Manzato³

et al. 2010

European Journal of Endocrinology

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The hemostatic balance is a complex system where the delicate equilibrium is regulated by several factors, including hormones. This review summarizes current knowledge of the effects of most frequent endocrine and metabolic diseases (such as hypothyroidism, hyperthyroidism, Cushing's syndrome, GH-related pituitary dysfunctions, pituitary prolactin-producing adenomas, polycystic ovary syndrome, primary hyperparathyroidism, and metabolic syndrome) on coagulation and fibrinolysis. Overt hypothyroidism appears to be associated with a bleeding tendency, whereas all other endocrine diseases appear to be associated with a thrombotic tendency. Globally, the disorders of coagulation and fibrinolysis usually range from mild to moderate, and, rarely, to severe laboratory abnormalities (for example, bleeding diathesis in overt hypothyroidism mainly due to an acquired von Willebrand's disease type 1). Further larger and high-quality studies are needed to provide more definitive information on the effects of endocrine disorders on coagulation and fibrinolysis.

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“…Similarly, patients with hyperthyroidism were found to have decreased levels of FIX, von Willebrand factor (VWF), antithrombin, and PAI-1, as well as decreased levels of t-PA, suggesting reduced plasma fibrinolytic capacity and predisposing them to a hypercoagulable state [12,13]. Furthermore, studies have demonstrated that in hyperthyroid patients the balance between t-PA and PAI-1 appears to favour PAI-1, resulting in impaired endothelial function.…”

Section: Rycina 3 Wartości Inr Dla Pacjentów Z Niskim Lub Prawidłowymentioning

confidence: 99%

Koncentracja hormonu tyreotropowego jako niezależny czynnik ryzyka żylnych powikłań zakrzepowo-zatorowych bez względu na czynność tarczycy

Kovářová

Koller

Štvrtinová

et al. 2015

Endokrynologia Polska

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Introduction: Thyroid dysfunction has been recognised as playing a role in the coagulation cascade, but the clinical implications of this phenomenon are unclear. The aim of our study was to assess the predictive power of TSH measurement on the presence or absence of venous thromboembolism (VTE). Material and methods: From January 2009 to August 2012, all consecutive patients hospitalised for suspected VTE were included in the study. VTE was confirmed either by pulmonary angiography or compressive ultrasound. We investigated the predictive power of TSH concentration on the risk of VTE in univariate and multivariate analysis including the existing risk factors (age, D-dimer). Results: A total of 232 patients were eligible for final analysis, with a median age of 70 years (IQR 58-80) and male-to-female ratio of 124:108. VTE was confirmed in 124 patients (53.4%). TSH concentration was significantly higher in cases with VTE (median 2.17 vs. 1.76 mIU/L, p = 0.0104), but free T4 concentrations were not found to be significantly different. Receiver operating curve analysis identified the cut-off of TSH > 2.686 mIU/L as a predictor of VTE with the prevalence of VTE 47.1 vs. 66.7% below and above this cut-off, p = 0.011.

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Plasma levels of free tissue factor pathway inhibitor in patients with various thyroid disorders

Cited by 23 publications

References 26 publications

Thrombin Activatable Fibrinolysis Inhibitor Antigen Levels Are Inversely Correlated with Plasminogen Activator Inhibitor-1 Antigen Levels in Hyperthyroid Patients

Thrombin Activatable Fibrinolysis Inhibitor Antigen Levels Are Inversely Correlated with Plasminogen Activator Inhibitor-1 Antigen Levels in Hyperthyroid Patients

Hemostatic abnormalities in endocrine and metabolic disorders

Koncentracja hormonu tyreotropowego jako niezależny czynnik ryzyka żylnych powikłań zakrzepowo-zatorowych bez względu na czynność tarczycy

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