Plasma levels of free fatty acids correlate with type 2 diabetes mellitus

Spiller, Sandro; Blüher, Matthias; Hoffmann, Ralf

doi:10.1111/dom.13449

Cited by 51 publications

(46 citation statements)

References 59 publications

(125 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An increase in FFAs was also observed in obese rats, confirming previous observations, not only in obesity but also in diabetes [25,26]. This accumulation could involve a higher FA uptake at both cellular and mitochondrial levels, as mentioned above due to increased lipid supply in obesity.…”

Section: Discussionsupporting

confidence: 90%

The Crosstalk between Cardiac Lipotoxicity and Mitochondrial Oxidative Stress in the Cardiac Alterations in Diet-Induced Obesity in Rats

Jiménez-González

Marín-Royo

Jurado-López

et al. 2020

Cells

View full text Add to dashboard Cite

The impact of the mitochondria-targeted antioxidant MitoQ was evaluated in the cardiac alterations associated with obesity. Male Wistar rats were fed either a high fat diet (HFD, 35% fat) or a standard diet (CT, 3.5% fat) for 7 weeks and treated with MitoQ (200 µM). The effect of MitoQ (5 nM) in rat cardiac myoblasts treated for 24 h with palmitic acid (PA, 200 µM) was evaluated. MitoQ reduced cardiac oxidative stress and prevented the development of cardiac fibrosis, hypertrophy, myocardial 18-FDG uptake reduction, and mitochondrial lipid remodeling in HFD rats. It also ameliorated cardiac mitochondrial protein level changes observed in HFD: reductions in fumarate hydratase, complex I and II, as well as increases in mitofusin 1 (MFN1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha, and cyclophilin F (cycloF). In vitro, MitoQ prevented oxidative stress and ameliorated alterations in mitochondrial proteins observed in palmitic acid (PA)-stimulated cardiac myoblasts: increases in carnitine palmitoyltransferase 1A, cycloF, and cytochrome C. PA induced phosphorylation of extracellular signal-regulated kinases and nuclear factor-κB p65. Therefore, the data show the beneficial effects of MitoQ in the cardiac damage induced by obesity and suggests a crosstalk between lipotoxicity and mitochondrial oxidative stress in this damage

show abstract

Section: Discussionsupporting

confidence: 90%

The Crosstalk between Cardiac Lipotoxicity and Mitochondrial Oxidative Stress in the Cardiac Alterations in Diet-Induced Obesity in Rats

Jiménez-González

Marín-Royo

Jurado-López

et al. 2020

Cells

View full text Add to dashboard Cite

show abstract

“…This type of cellular “starvation” is covered by release of fatty acids from triglycerides which in turns results in higher NEFA concentrations [ 39 ]. On the other hand, for decades it has gained widespread acceptance that high concentrations of NEFAs can contribute to insulin resistance, e.g.by the toxic influence on pancreatic β-cells and thus impaired insulin secretion and peripheral sensitivity to insulin, and also by increasing activation of proinflammatory cytokines as well as oxidative stress [ 40 ]. Results obtained in this study indicated that the increase in circulating NEFAs in lung cancer patients was associated with elevated glucose concentration.…”

Section: Discussionmentioning

confidence: 99%

Systemic redox status in lung cancer patients is related to altered glucose metabolism

et al. 2018

View full text Add to dashboard Cite

Altered systemic redox status is often observed in lung cancer. However, detailed information on factors other, than smoking, which influence this perturbation is rather scarce. Elevated oxidative stress has been linked with disturbances in glucose metabolism before, but such associations have not been investigated in lung cancer. The aim of this study was to evaluate the relationship between systemic parameters of glucose metabolism and redox status in lung cancer patients (LC). Biochemical variables related to circulating glucose, i.e. glucose, insulin, c-peptide, fructosamine (FA), and glucose metabolism, i.e. β-hydroxybutyrate (BHB), lactate (LACT), non-esterified fatty acids (NEFAs), as well as redox status i.e. total antioxidant status (TAS) and total oxidant status (TOS) were determined for LC (n = 122) and control subjects (CS) (n = 84). HOMA-IR and the oxidative stress index (OSI) were calculated. LC patients had an altered redox status and glucose metabolism compared to CS. Positive correlations in LC were observed between TOS, OSI and circulating glucose as well as FA, while TAS positively correlated with BHB and NEFAs. In contrast, in metastatic LC, NEFAs and BHB positively correlated with OSI. Smoking status additionally stratified the observed relationships. In conclusion, we found that parameters related to circulating glucose or non-enzymatic glycation were correlated with oxidative stress (TOS and OSI), while metabolites such as BHB and NEFAs were correlated with antioxidant capacity (TAS). Metastasis prevalence and smoking seem to influence these correlations. However, the detailed mechanism of this relationship requires further research, in particular as regards the surprising positive correlation between NEFAs and TAS.

show abstract

“…The authors further recommend the measurement of serum FFA concentration in combination with existing diabetic diagonostic tools to improve the diagnostic accuracy. This study ranked the earlier diagnostic accuracy from the newly diagnosed diabetic patients to those monitored for a long time [132]. Yi et al [133] demonstrated both esterified and non-esterified FA to screen the DM patients from healthy ones.…”

Section: Biomarkers Of Disturbed Lipid Metabolismmentioning

confidence: 92%

Altered Metabolome of Lipids and Amino Acids Species: A Source of Early Signature Biomarkers of T2DM

Hameed

Mojsak

Buczyńska

et al. 2020

JCM

View full text Add to dashboard Cite

Diabetes mellitus, a disease of modern civilization, is considered the major mainstay of mortalities around the globe. A great number of biochemical changes have been proposed to occur at metabolic levels between perturbed glucose, amino acid, and lipid metabolism to finally diagnoe diabetes mellitus. This window period, which varies from person to person, provides us with a unique opportunity for early detection, delaying, deferral and even prevention of diabetes. The early detection of hyperglycemia and dyslipidemia is based upon the detection and identification of biomarkers originating from perturbed glucose, amino acid, and lipid metabolism. The emerging “OMICS” technologies, such as metabolomics coupled with statistical and bioinformatics tools, proved to be quite useful to study changes in physiological and biochemical processes at the metabolic level prior to an eventual diagnosis of DM. Approximately 300–400 such metabolites have been reported in the literature and are considered as predicting or risk factor-reporting metabolic biomarkers for this metabolic disorder. Most of these metabolites belong to major classes of lipids, amino acids and glucose. Therefore, this review represents a snapshot of these perturbed plasma/serum/urinary metabolic biomarkers showing a significant correlation with the future onset of diabetes and providing a foundation for novel early diagnosis and monitoring the progress of metabolic syndrome at early symptomatic stages. As most metabolites also find their origin from gut microflora, metabolism and composition of gut microflora also vary between healthy and diabetic persons, so we also summarize the early changes in the gut microbiome which can be used for the early diagnosis of diabetes.

show abstract

Plasma levels of free fatty acids correlate with type 2 diabetes mellitus

Cited by 51 publications

References 59 publications

The Crosstalk between Cardiac Lipotoxicity and Mitochondrial Oxidative Stress in the Cardiac Alterations in Diet-Induced Obesity in Rats

The Crosstalk between Cardiac Lipotoxicity and Mitochondrial Oxidative Stress in the Cardiac Alterations in Diet-Induced Obesity in Rats

Systemic redox status in lung cancer patients is related to altered glucose metabolism

Altered Metabolome of Lipids and Amino Acids Species: A Source of Early Signature Biomarkers of T2DM

Contact Info

Product

Resources

About