Plasma levels of fibroblast growth factor‐23 are associated with muscle mass in haemodialysis patients

Fukasawa, Hirotaka; Ishigaki, Sayaka; Kinoshita-Katahashi, Naoko; Niwa, Hiroki; Yasuda, Hideo; Kumagai, Hiromichi; Furuya, Ryuichi

doi:10.1111/nep.12333

Cited by 19 publications

(20 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although FGF23 levels are likely to be consistently higher in XLH than during exercise, the study by Li et al identifies a novel effect of FGF23 on skeletal muscle, which may be induced by the high FGF23 levels in XLH. Plasma levels of FGF23 are also positively associated with muscle mass in haemodialysis patients, which could indicate a role for FGF23 in improving muscle strength [191].…”

Section: Background and Introductionmentioning

confidence: 99%

FGF23 and its role in X-linked hypophosphatemia-related morbidity

Beck-Nielsen

Mughal

Haffner

et al. 2019

Orphanet J Rare Dis

187

229

View full text Add to dashboard Cite

Background X-linked hypophosphatemia (XLH) is an inherited disease of phosphate metabolism in which inactivating mutations of the Phosphate Regulating Endopeptidase Homolog, X-Linked ( PHEX ) gene lead to local and systemic effects including impaired growth, rickets, osteomalacia, bone abnormalities, bone pain, spontaneous dental abscesses, hearing difficulties, enthesopathy, osteoarthritis, and muscular dysfunction. Patients with XLH present with elevated levels of fibroblast growth factor 23 (FGF23), which is thought to mediate many of the aforementioned manifestations of the disease. Elevated FGF23 has also been observed in many other diseases of hypophosphatemia, and a range of animal models have been developed to study these diseases, yet the role of FGF23 in the pathophysiology of XLH is incompletely understood. Methods The role of FGF23 in the pathophysiology of XLH is here reviewed by describing what is known about phenotypes associated with various PHEX mutations, animal models of XLH, and non-nutritional diseases of hypophosphatemia, and by presenting molecular pathways that have been proposed to contribute to manifestations of XLH. Results The pathophysiology of XLH is complex, involving a range of molecular pathways that variously contribute to different manifestations of the disease. Hypophosphatemia due to elevated FGF23 is the most obvious contributor, however localised fluctuations in tissue non-specific alkaline phosphatase (TNAP), pyrophosphate, calcitriol and direct effects of FGF23 have been observed to be associated with certain manifestations. Conclusions By describing what is known about these pathways, this review highlights key areas for future research that would contribute to the understanding and clinical treatment of non-nutritional diseases of hypophosphatemia, particularly XLH.

show abstract

Section: Background and Introductionmentioning

confidence: 99%

FGF23 and its role in X-linked hypophosphatemia-related morbidity

Beck-Nielsen

Mughal

Haffner

et al. 2019

Orphanet J Rare Dis

187

229

View full text Add to dashboard Cite

show abstract

“…In several crosssectional studies of haemodialysis patients, higher serum FGF23 levels were associated with lower age, higher body mass index, higher serum albumin, serum creatinine and geriatric nutritional risk index, and normalized protein catabolic index, larger abdominal muscle mass areas and creatinine production (another indicator of muscle mass). [23][24][25] A high-fat diet stimulated FGF23 production in mice. 26 In recent in vivo and in vitro studies involving mice and osteoblast-like cells, the effect of energy balance on FGF23 production was controlled by AMPactivated protein kinase, which works as a cellular energy sensor.…”

Section: Discussionmentioning

confidence: 99%

“…Those subjects, however, also had highest age, lowest body mass index, serum albumin and creatinine, which all indicate malnutrition. In several cross‐sectional studies of haemodialysis patients, higher serum FGF23 levels were associated with lower age, higher body mass index, higher serum albumin, serum creatinine and geriatric nutritional risk index, and normalized protein catabolic index, larger abdominal muscle mass areas and creatinine production (another indicator of muscle mass) 23‐25 . A high‐fat diet stimulated FGF23 production in mice 26 .…”

Section: Discussionmentioning

confidence: 99%

Association of erythropoietin resistance and fibroblast growth factor 23 in dialysis patients: Results from the Japanese Dialysis Outcomes and Practice Patterns Study

et al. 2020

View full text Add to dashboard Cite

Background: Fibroblast growth factor 23 (FGF23) plays an important role in chronic kidney disease (CKD)-related mineral and bone disorders. High FGF23 levels are associated with increased risk of anaemia in non-haemodialysis CKD patients. FGF23 also negatively regulates erythropoiesis in mice. We hypothesized that higher FGF23 levels are associated with increased erythropoietin hyporesponsiveness among haemodialysis patients. Methods: The study included 1044 patients from the Japanese Dialysis Outcomes and Practice Patterns Study (J-DOPPS) phase 5 (2012-2015). The outcome was erythropoiesis-stimulating agent hyporesponsiveness (ESA-hypo), defined as mean Hgb <10 g/dL and standardized mean ESA dose >6000 u/week over 4 months following FGF23 measurement. The association between ESA-hypo and FGF23 was estimated using multivariable-adjusted logistic generalized estimating equation regression models. Results: Patients with higher levels of FGF23 were younger and had higher levels of serum albumin, creatinine, albumin-corrected calcium, phosphorus, PTH, 25(OH)vitamin D, and had higher percentages of intravenous (IV) iron, IV vitamin D and cinacalcet use. ESA-hypo was present in 144 patients (13.8%). Compared with the third quintile of FGF23 levels, the odds ratio (95% CI) of ESA-hypo was 2.14 (0.99, 4.62) and 1.74 (0.74, 4.11) for the first and fifth quintiles, respectively. Conclusion: The lowest and highest levels of FGF23 were associated with higher odds of ESA-hypo in patients on maintenance haemodialysis, although the associations were not statistically significant. The relationship between FGF23 and anaemia,

show abstract

“…5 Fibroblast Growth Factor-23 berikatan kuat terhadap reseptor FGF-23 pada otot skeletal dan memengaruhi massa otot. 6 Penilaian kekuatan otot pada pasien PGK dapat menggunakan parameter penilaian kekuatan genggam tangan 7,8 dan memiliki korelasi baik dengan kekuatan berbagai kelompok otot dan penilaiannya sangat mudah dan cepat. 9 Kami menduga bahwa kadar FGF-23 yang tinggi dapat memengaruhi kekuatan genggam tangan yang kemudian berkontribusi pada aktivitas fisik pasien PGK yang menjalani hemodialisis.…”

Section: Pendahuluanunclassified

“…Kadar FGF-23 yang tinggi dapat berkaitan kuat dengan reseptornya di otot skeletal yang secara independen terhadap α-Klotho. 6 Avin, dkk. 31 melakukan penelitian untuk mencari hubungan FGF-23 langsung terhadap otot skeletal.…”

Section: Diskusiunclassified

Korelasi kadar Fibroblast Growth Factor-23 dengan Kekuatan Genggam Tangan pada Pasien Hemodialisis Dua Kali Seminggu

Lydia¹,

Gaol²,

Suhardjono³

et al. 2020

JPDI

View full text Add to dashboard Cite

ABSTRAKPendahuluan. Salah satu faktor utama yang terlibat dalam gangguan mineral tulang dan muskuloskeletal pada pasien penyakit ginjal kronik (PGK) adalah fibroblast growth factor-23 . Peningkatan kadar FGF-23 terjadi pada awal PGK dan semakin meningkat pada PGK tahap akhir terutama yang menjalani dialisis. Fibroblast growth factor-23 perlu mendapat perhatian khusus karena perannya terhadap otot skeletal pada pasien PGK yang menjalani hemodialisis belum diketahui secara pasti. Penelitian ini dilakukan untuk mengetahui korelasi antara kekuatan genggam tangan (KGT) dengan kadar FGF-23 pada pasien yang menjalani hemodialisis dua kali seminggu.Metode. Penelitian ini merupakan studi potong lintang yang dilaksanakan di Unit Hemodialisis Rumah Sakit Dr. Cipto Mangunkusumo Jakarta, pada pasien yang mendapatkan dialisis 2 kali seminggu. Pengukuran FGF dengan pemeriksaan intact fibroblast growth factor-23 (iFGF-23) dan menilai KGT dengan dinamometer hidraulik tangan merek Jamar. Pemilihan subjek dilakukan secara consecutive sampling sampai jumlah subjek yang diperlukan terpenuhi. Hasil.Subjek pada penelitian ini sebanyak 74 subjek dengan kadar pemeriksaan FGF-23 pada laki-laki (median 3.276 pg/ml [rentang 41-6.613 pg/ml]) lebih tinggi dibandingkan dengan perempuan (median 1.585 pg/ml [rentang 21-4.820 pg/ml]). Nilai median KGT pasien laki-laki adalah 25 kg (rentang 11-48 kg), sedangkan pada perempuan adalah 20 kg (rentang 8-26 kg). Setelah dilakukan penyesuaian dengan indeks komorbid charlson modifikasi dan indeks massa tubuh, tidak didapatkan korelasi antara FGF-23 dengan KGT pada subjek laki-laki (r=-0,053, p=0,7), akan tetapi terdapat korelasi negatif bermakna pada subjek perempuan (r=-0,4, p=0,02).Simpulan. Kadar FGF-23 memiliki korelasi negatif bermakna dengan KGT pada perempuan dengan IMT >18,5 kg/m 2 dan hal tersebut tidak ditemukan pada subjek penelitian laki-laki.Kata Kunci: FGF-23, hemodialisis, kekuatan genggam tangan ABSTRACT Introduction. One of the main factors involved in bone mineral and musculoskeletal disorders in patients with chronic kidney disease (CKD) is fibroblast growth factor-23 (FGF-23). Fibroblast growth factor 23 (FGF-23) levels are elevated in hemodialysis patients. Despite FGF-23 associated left ventricular hypertrophy, there are no prior studies assessing whether FGF-23 level is associated with skeletal muscle strength in hemodialysis patient. This study aimed to determine the correlation between hand-grip strength (HGS) and FGF-23 levels in patients undergoing twice weekly hemodialysis patients. Methods. A cross-sectional study was conducted on patients with twice weekly hemodialysis at the Hemodialysis Unit atDr Cipto Mangunkusumo Hospital, Jakarta. We measured intact fibroblast growth factor-23 and hand grip strength that measured by Jamar hydraulic hand dynamometer. Subject selection was done by consecutive sampling until the required number of subjects was fulfilled. Results.A total of 74 subjects were included in this study which serum FGF23 levels were significantly higher in males (...

show abstract

Plasma levels of fibroblast growth factor‐23 are associated with muscle mass in haemodialysis patients

Abstract: Plasma FGF-23 concentrations were associated with muscle mass indices in HD patients. Our findings suggest that FGF-23 and nutritional status are linked and this link is most likely independent of s-Klotho.

Cited by 19 publications

References 29 publications

FGF23 and its role in X-linked hypophosphatemia-related morbidity

FGF23 and its role in X-linked hypophosphatemia-related morbidity

Association of erythropoietin resistance and fibroblast growth factor 23 in dialysis patients: Results from the Japanese Dialysis Outcomes and Practice Patterns Study

Korelasi kadar Fibroblast Growth Factor-23 dengan Kekuatan Genggam Tangan pada Pasien Hemodialisis Dua Kali Seminggu

Contact Info

Product

Resources

About