Plasma levels of endothelin-1 in diabetic retinopathy in pregnancy

Rm, Best; Hayes, R.G.J.; Dr, Hadden; Chakravarthy, Usha; Db, Archer

doi:10.1038/eye.1999.47

Cited by 12 publications

(2 citation statements)

References 14 publications

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“…They also found that ET-1 serum levels were similar in women with and without vascular complications of diabetes; even in women who experienced preeclampsia ET-1 con- [6,7,19] while ET-1 has even been suggested as a sensitive marker of preeclampsia [8] . Similarly, Best et al [20] reported higher ET-1 serum levels in women with PGDM, and concomitant diabetic retinopathy did not influence these results. Some other reports have confirmed higher ET-1 levels in PGDM women, with peak values achieved at term [21] .…”

Section: Discussionmentioning

confidence: 80%

Maternal Endothelin-1 and Cyclic Guanosine Monophosphate Concentrations in Pregnancies Complicated by Pregravid and Gestational Diabetes Mellitus

Świderski¹,

Celewicz²,

Miazgowski

et al. 2009

Gynecol Obstet Invest

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Background/Aims: Pregnancy complicated by diabetes is associated with increased risk of unfavorable obstetric outcomes. A common abnormality in diabetes is endothelial dysfunction resulting in an altered pattern of vasoactive substance production by the endothelial cells. The aim of study was to assess serum endothelin-1 (ET-1) and cyclic guanosine monophosphate (cGMP) in pregnant women with pregravid (PGDM) or gestational diabetes (GDM). Methods: At the time of delivery, serum ET-1, cGMP, glycated hemoglobin (A1c), fructosamine and non-fasting glucose were measured in 19 PGDM, 23 GDM and 18 controls. Results: ET-1 and cGMP were similar in all groups. In GDM there was a positive association between A1c and ET-1 (r = 0.437; p < 0.05) and cGMP (r = 0.542; p < 0.02). In the controls, but not in PGDM and GDM, we found a positive correlation between ET-1 and cGMP (r = 0.634; p < 0.005). In women with diabetes, an optimal (A1c <6%) or inadequate (A1c >6%) metabolic control of diabetes did not influence ET-1 or cGMP levels. Conclusions: In women with PGDM and GDM, serum ET-1 and cGMP were similar to the levels observed in healthy pregnant women. However, the physiological balance between vasoconstrictor and vasodilator substances might be defective in pregnancies complicated by diabetes.

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Section: Discussionmentioning

confidence: 80%

Maternal Endothelin-1 and Cyclic Guanosine Monophosphate Concentrations in Pregnancies Complicated by Pregravid and Gestational Diabetes Mellitus

Świderski¹,

Celewicz²,

Miazgowski

et al. 2009

Gynecol Obstet Invest

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“…[ 52 ] Low levels of glycoprotein glycodelin, secreted by the endometrium, which is key in inhibiting E-selectin that promotes leucocyte–endothelium adhesion, has been associated with progression of retinopathy. [ 53 ] Similarly, increased levels of endothelin-1 are speculated to cause endothelial damage in pregnancy leading to pregnancy-induced hypertension and progression of DR.[ 54 ]…”

Section: Hyperglycemia In Pregnancymentioning

confidence: 99%

Diabetic retinopathy in pregnancy - A review

Chandrasekaran

Madanagopalan

Narayanan

2021

Indian Journal of Ophthalmology

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Diabetes and gestational diabetes (GD) are areas of concern worldwide. GD can eventually lead to serious development of diabetic retinopathy (DR) during pregnancy or worsening of an already existing DR. GD confers future risk of diabetes, both in the mother and fetus, further complicating their lives. DR in pregnant women has been intriguing in terms of understanding the prevalence, assessing risk factors causing pathogenesis, and problems associated with treating them. Pregnancy itself is a risk factor for progression of DR. Physiological changes such as metabolic, vascular, immunologic, and hormonal changes that occur during pregnancy can cause development as well as worsening of DR. This can eventually lead to permanent visual loss if not addressed on time. Timing of laser, choice of treatment for diabetic macular edema with laser, intravitreal anti-vascular endothelial growth factor agents (VEGF), and intravitreal steroids pose a serious challenge in managing these patients without causing damage to the mother and fetus. This review article showcases the prevalence, risk factors, and pathogenesis, outlines the management of DR in pregnancy, and recommends guidelines based on the available evidence. PubMed and MEDLINE searches were performed pertaining to the prevalence of GD in India, DR in pregnancy, risk factors for progression of DR, role of vasoactive mediators in DR, role of angiopoietic factors in DR, hormonal influence of DR, role of growth factors in DR, use of fluorescein and indocyanine green angiography, retinal lasers, anti-VEGF agents, intravitreal steroids, anesthesia, and retinal surgery, all pertaining to pregnancy and guidelines and recommendations for managing DR in pregnancy.

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Circulating asymmetric dimethylarginine, endothelin-1 and cell adhesion molecules in women with gestational diabetes

et al. 2009

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We measured plasma concentrations of asymmetric dimethylarginine (ADMA), endothelin-1 (ET-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and E-selectin in 56 patients with gestational diabetes (GDM), 68 pregnant women with normal glucose tolerance (NGT) and 36 healthy non-pregnant women. ADMA concentrations were markedly lower in NGT [0.48 (0.42-0.55) micromol/l] than in GDM subjects [0.50 (0.43-0.67) micromol/l] and healthy controls [0.57 (0.46-0.72) micromol/l, P = 0.005]. ET-1 levels were comparable between GDM [0.76 (0.58-0.90) pg/ml] and NGT women [0.75 (0.63-0.92) pg/ml] and significantly higher than in the non-pregnant subjects [0.62 (0.52-0.72) pg/ml, P = 0.007 and P = 0.005, respectively]. There were no differences in sVCAM-1 and E-selectin levels between the groups studied. ADMA levels were significantly associated with fasting glucose (beta = 0.23, P = 0.02) and gestational age (beta = 0.24, P = 0.01). Our results suggest that physiological adaptation to pregnancy is associated with a fall in circulating ADMA and an elevation of ET-1 concentrations, irrespective of the disturbances of glucose tolerance.

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Plasma levels of endothelin-1 in diabetic retinopathy in pregnancy

Cited by 12 publications

References 14 publications

Maternal Endothelin-1 and Cyclic Guanosine Monophosphate Concentrations in Pregnancies Complicated by Pregravid and Gestational Diabetes Mellitus

Maternal Endothelin-1 and Cyclic Guanosine Monophosphate Concentrations in Pregnancies Complicated by Pregravid and Gestational Diabetes Mellitus

Diabetic retinopathy in pregnancy - A review

Circulating asymmetric dimethylarginine, endothelin-1 and cell adhesion molecules in women with gestational diabetes

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