Plasma levels of B-type natriuretic peptide in patients with tetralogy of Fallot after surgical repair

Koch, Andreas; Zink, Stefan; Glöckler, Martin; Seeliger, Theresa; Dittrich, Sven

doi:10.1016/j.ijcard.2009.01.062

Cited by 32 publications

(23 citation statements)

References 33 publications

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“…Antihypertensive beta-blocker therapy has been shown to cause elevated natriuretic peptide levels, as well as to increase the frequency of atrial fibrillation in hypertensive patients. The measurement of natriuretic peptides might help solve the clinical challenge of predicting the patients with high risk for beta-blocker induced atrial fibrillation.We thank Koch et al [1] for complementing our case report [2]. The study of young patients with high degree atrioventricular block confirmed, in high number of cases, our observation that bradycardia can cause increased plasma B-type natriuretic peptide (BNP) level.…”

supporting

confidence: 71%

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Bradycardia and B-type natriuretic peptide

Kováts¹,

Tomcsányi²

2009

International Journal of Cardiology

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supporting

confidence: 71%

“…We thank Koch et al [1] for complementing our case report [2]. The study of young patients with high degree atrioventricular block confirmed, in high number of cases, our observation that bradycardia can cause increased plasma B-type natriuretic peptide (BNP) level.…”

supporting

confidence: 71%

Bradycardia and B-type natriuretic peptide

Kováts¹,

Tomcsányi²

2009

International Journal of Cardiology

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“…2) (5)(6)(7)(8)(9)(10)12,14,16,17). Patients with NYHA functional class II revealed significantly higher BNP values than patients with NYHA class I (p ϭ 0.01) ( Table 1) (12,15).…”

Section: Resultsmentioning

confidence: 97%

The Usefulness of Brain Natriuretic Peptide in Complex Congenital Heart Disease

Eindhoven¹,

Bosch²,

Jansen³

et al. 2012

Journal of the American College of Cardiology

148

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Brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) are well-established markers for heart failure in the general population. However, the value of BNP as a diagnostic and prognostic marker for patients with structural congenital heart disease (CHD) is still unclear. Therefore, the purpose of this study was to evaluate the clinical utility of BNP in patients with CHD. We executed a PubMed literature search and included 49 articles that focused on complex congenital heart defects such as tetralogy of Fallot, systemic right ventricle, and univentricular hearts. Data on BNP measurements and cardiac function parameters were extracted. In all patients after correction for tetralogy of Fallot, BNP levels were elevated and correlated significantly with right ventricular end-diastolic dimensions and severity of pulmonary valve regurgitation. Patients with a systemic right ventricle had elevated BNP levels, and positive correlations between BNP and right ventricular function were seen. In patients with a univentricular heart, elevated BNP levels were observed before completion of the Fontan circulation or when patients were symptomatic; a clear association between BNP and New York Heart Association functional class was demonstrated. In conclusion, this review shows an overall increase in BNP values in complex CHD, although differences between types of congenital heart anomaly are present. As BNP values differ widely, conclusions for individual patients should be drawn with caution. Further investigation with sequential BNP measurement in a large, prospective study is warranted to elucidate the prognostic value of BNP assessment in patients with CHD.

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“…They also performed exercise testing and echocardiograms. BNP levels were increased above normal gender and age specific values in 60% of the patients, but were less than 200 pg/ml in all patients (Koch et al 2010). BNP levels were higher in patients awaiting pulmonary valve replacement, and in those in NYHA class II compared to class I.…”

Section: Long-term Outcomesmentioning

confidence: 75%