Plasma levels of active ghrelin until 8 weeks after birth in preterm infants: relationship with anthropometric and biochemical measures

Shimizu, Toshiaki; Kitamura, Tsuneo; Yoshikawa, Naomi; Suganuma, H; Hisata, Ken; Tanaka, Kanako; Shinohara, Koichi; Yamashiro, Y

doi:10.1136/adc.2005.092379

Cited by 17 publications

(19 citation statements)

References 5 publications

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“…However, high ghrelin levels may also be explained by an intrinsic characteristic of the preterm born infants. In fact, in the study by Shimizu et al (8), it was shown that active ghrelin levels were increased in low birth weight infants in the first 8 weeks of life, and similar to our study the ghrelin levels did not differ between the AGA and SGA infants. The inverse relation of ghrelin with gestational age in our study may also imply this hypothesis.…”

Section: Discussionsupporting

confidence: 76%

“…This finding shows that the increased levels of ghrelin in preterm born children in the early neonatal period (7,8) are sustained up to prepubertal ages. This increase in ghrelin levels may be needed for the growth of these children, but it does not seem to be related to the degree of CUG because preterm SGA infants had significantly higher CUG than preterm AGA children in spite of similar ghrelin levels.…”

Section: Discussionmentioning

confidence: 54%

“…This ghrelin refractoriness to food intake from birth to childhood may suggest that this hormone may play an anabolic drive in the growth and development. In fact, it has been shown that small for gestational age (SGA) and very low birth weight infants show higher increase in ghrelin levels at birth and after birth, which may indicate increased physiological need for ghrelin (8,11,12). Higher postprandial ghrelin levels or lower reductions in circulating ghrelin levels following IV glucose were also found in SGA born children who showed greater catch-up growth (CUG) at 1 year of age (13).…”

Section: Introductionmentioning

confidence: 75%

“…It has been shown that early in the neonatal period ghrelin levels increase in preterm infants (7,8). Interestingly, this increase is not inhibited by food intake (7).…”

Section: Introductionmentioning

confidence: 99%

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Elevated ghrelin levels in preterm born children during prepubertal ages and relationship with catch-up growth

Darendelıler

Baş²,

Bundak³

et al. 2008

European Journal of Endocrinology

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Background: Ghrelin, the natural ligand of the GH secretagogue receptor, has potent orexigenic effect. Ghrelin levels are negatively associated with insulin secretion, increased in anorexia, and reduced in obesity. Increased ghrelin levels may be associated with early postnatal growth in preterm born children. Objective: Aim of this study was to evaluate ghrelin and insulin levels at prepubertal ages in preterm born children born appropriate for gestational age (AGA) or small for gestational age (SGA) and relationships with catch-up growth (CUG) in a prospective cross-sectional study. Methods: Eighty-four preterm born children grouped as preterm SGA (nZ28) and preterm AGA (nZ56) were evaluated at age 4.7G0.2 and 4.7G0.1 years with respect to their ghrelin and insulin levels. Their data were compared with that of body mass index matched term SGA (nZ35) and term AGA (nZ44) children of age 4.6G0.2 and 3.8G0.1 years. All children had height appropriate for their target height. CUG was defined as the difference between birth size and recent size and expressed as D height and D weight SDS. Results: Preterm SGA and preterm AGA children had similar ghrelin levels (1717.0G166.9 and 1656.5G103.8 pg/ml), although D height and D weight SDS in preterm SGA were significantly higher than in preterm AGA children (P!0.001). Ghrelin levels in both preterm groups were higher than term SGA (469.2G132.5 pg/ml) and term AGA children (659.6G143.3 pg/ml; P!0.001 for all). D Height and D weight SDS of the term SGA children were similar to that of preterm SGA children. Ghrelin did not have correlation with CUG but had inverse correlation with recent anthropometric indices. Insulin was significantly higher in term SGA children than other groups (P!0.001). Conclusions: Preterm children have higher ghrelin levels at prepubertal ages regardless of the magnitude of their CUG. Term SGA children, on the other hand, behave differently and have lower ghrelin levels than preterm children at prepubertal ages, which may be related to elevated insulin levels in this group.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 75%

“…It has been shown that early in the neonatal period ghrelin levels increase in preterm infants (7,8). Interestingly, this increase is not inhibited by food intake (7).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Elevated ghrelin levels in preterm born children during prepubertal ages and relationship with catch-up growth

Darendelıler

Baş²,

Bundak³

et al. 2008

European Journal of Endocrinology

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“…Accordingly, James et al (31) postulated that lower cord ghrelin levels were associated with gradual weight gain from birth to 3 months of age. It has been shown that ghrelin levels increase in preterm infants early in the neonatal period (13,23,29) and this increase is not inhibited by food intake (13,29). So, ghrelin may play a physiological role in fetal adaptation to intrauterine malnutrition, and early changes in active ghrelin levels in the early neonatal period in preterm infants might suggest a possible role of active ghrelin in the adaptation of the neonatal metabolism to the extrauterine life with an anabolic drive during this growth and development period.…”

Section: Discussionmentioning

confidence: 99%

The relationship of active ghrelin levels and intrauterine growth in preterm infants

Hamilçıkan

Erener²,

Erginöz³

et al. 2012

European Journal of Endocrinology

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Objective: We examined the association of active ghrelin levels with birth weight, sex, and gestational age (GA) in small for GA (SGA) and appropriate for GA (AGA) preterm infants. Methods: Active ghrelin levels were measured by ELISA method during the first five postnatal days in 38 preterm SGA infants and 32 preterm AGA controls. Results: Active ghrelin levels were significantly higher in preterm SGA infants than in preterm AGA controls (P!0.01). Active ghrelin levels in preterms with birth weight !1500 g were statistically higher than those over 1500 g. Active ghrelin levels in preterms %34 gestational weeks were similar to those over 34 weeks. A negative correlation was detected between active ghrelin levels and birth weight (rZK0.561, P!0.0001) as well as GA (rZK0.449, P!0.0001). Conclusion: We found significantly higher active ghrelin levels in SGA preterms than those in AGA preterms and demonstrated a negative correlation between active ghrelin levels and birth weight in preterm infants. This was the first study showing a negative correlation between active ghrelin levels and birth weight in preterm infants.

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Hormones and Gastrointestinal Function of Newborns

Prodam¹,

Bellone²,

Ricotti³

et al. 2016

Neonatology

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Plasma levels of active ghrelin until 8 weeks after birth in preterm infants: relationship with anthropometric and biochemical measures

Cited by 17 publications

References 5 publications

Elevated ghrelin levels in preterm born children during prepubertal ages and relationship with catch-up growth

Elevated ghrelin levels in preterm born children during prepubertal ages and relationship with catch-up growth

The relationship of active ghrelin levels and intrauterine growth in preterm infants

Hormones and Gastrointestinal Function of Newborns

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