Plasma Levels of a New Pelletized Form of Amitriptyline for Maintenance Therapy

Abstract

Plasma levels of amitriptyline and nortriptyline were measured in volunteers after one week of daily dosage with either 25 mg t.i.d. of standard amitriptyline tablets or a single 75-mg capsule of a new pelletized form of amitriptyline. Concentrations of both compounds were essentially equal at the end of one week's dosage with either dosage form but were somewhat higher throughout the dosing time interval for the pelletized drug.

Discrepancies Between Pharmacokinetic Studies of Amitriptyline

“…It is therefore difficult to compare clearances from single-versus multipledose studies. From the data of Hucker et al (1975), we believe that a 10 to 20% overestimation of the mean CLo occurs when we use equation 7 to calculate CLa from the concentrations of amitriptyline obtained at the times shown in table IV, but we nevertheless calculated CLa for the multipledose administration studies.…”

“…The importance of the timing for blood sampling is also well illustrated by the study of Hucker et al (1975). This study was conducted in normal subjects who received either once daily or three times daily doses of amitriptyline, and is the only multiple-dose study in which many samples were drawn during a 24-hour period at steady-state.…”

“…However, equation 8 gave a mean and median value of CLo which was, respectively, 85 and 92% of the value for CLo obtained from equation 7 using the concentration of amitriptyline at 12 hours. From the work of Hucker et al (1975), the optimum sampling time to obtain the best estimate of mean css is about 10 hours after the last dose of amitriptyline.…”

Safety and efficacy of tamsulosin in the treatment of painful ejaculation: a randomized, double-blind, placebo-controlled study

“…2,3 It can be caused by prostatectomy, 4,5 a history of prostatitis, 6 pelvic radiation, 7,8 lower urinary tract symptoms (LUTS) diagnosed with clinical benign prostatic hyperplasia (BPH), 9,10 chronic pelvic pain disorder, 11 and neuroleptics. [12][13][14][15][16][17][18] On the other hand, PE as a sole entity is rare, and its etiology often remains unknown. No urogenital, infectious, psychological or neurological diseases are associated with the symptoms.…”

Éjaculation douloureuse

“…L'éjaculation douloureuse est ainsi décrite avec l'imipramine, la désipramine, la clomipramine, la protriptyline, l'amoxapine, la fluoxétine, la venlafaxine et la réboxétine [32][33][34][35][36][37][38][39]. Les antagonistes des a1A-adrénergi-ques peuvent déterminer des douleurs éjaculatoires [40].…”