Plasma Level of Triglyceride-rich Lipoprotein Remnants Is Closely Associated with the Activation of Coagulation Factor VII in Patients with Myocardial Infarction

Saigo, Masahiko; Abe, Satoshi; Ogawa, Masanori; Biro, Sadatoshi; Minagoe, Shinichi; Maruyama, Ikuro; Toda, Hitoshi; Kiyonaga, Kazuaki; Atsuchi, Yoshihiko; Tahara, Masaki; Mawatari, Koshi

doi:10.1016/s0049-3848(00)00290-5

Cited by 10 publications

(6 citation statements)

References 38 publications

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“…Saigo et al . recently reported that there was a positive correlation between remnant‐like particles, triglyceride level, and FVIIa in patients with a history of myocardial infarction [25]. The increase of FVII:C in the rabbits fed with HC diet could either be due to an increase in the concentration of FVII, i.e.…”

Section: Discussionmentioning

confidence: 99%

Characterization of a tissue factor/factor VIIa‐dependent model of thrombosis in hypercholesterolemic rabbits

Gibson

et al. 2004

Journal of Thrombosis and Haemostasis

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Summary. Tissue factor (TF) expressed in arterial atherosclerotic plaque plays a key role in activating the extrinsic coagulation pathway and triggering acute coronary syndromes. In this study, we developed and characterized a TF±factor (F)VIIa-mediated thrombosis model in rabbits. Balloon catheter-induced endothelial denudation in the femoral artery and a 4-week high cholesterol diet produced a localized atherosclerotic plaque at the injured site. High levels of TF mRNA and TF protein antigen (152 AE 25 vs. 49 AE 12 pg mg À1 protein in normal vessels) were detected in these atherosclerotic plaques. Plasma FVII coagulant activity (FVII:C) was signi®cantly increased in the hypercholesterolemic rabbits (36 AE 1 s) compared with the normal rabbits (44 AE 1 s, P < 0.0001). Plaque rupture was induced by balloon angioplasty, which resulted in thrombus formation in the injured vessel segment after a brief period of stasis. FVIIai, a speci®c TF±FVIIa inhibitor, was administered intravenously to rabbits before plaque rupture at 0.3 and 1.0 mg kg À1 . FVIIai dose-dependently reduced thrombus mass (14.7 AE 2.5 and 5.9 AE 2.2 mg, respectively, vs. 21.6 AE 1.9 mg in the control group). PD198961, a novel factor Xa inhibitor, and argatroban, a thrombin inhibitor, also dosedependently inhibited thrombosis. These results indicate that thrombus formation in this model is initiated by the activation of TF±FVIIa pathway, which is attributed to TF expression in the atherosclerotic plaque and enhanced plasma FVII coagulant activity. This model may be useful for evaluating in vivo ef®cacy of new antithrombotic drugs, particularly TF±FVIIa inhibitors.

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Section: Discussionmentioning

confidence: 99%

Characterization of a tissue factor/factor VIIa‐dependent model of thrombosis in hypercholesterolemic rabbits

Gibson

et al. 2004

Journal of Thrombosis and Haemostasis

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“…In fact, TRLs and their remnants stimulate endothelial cell plasminogen activator inhibitor-1 production [52], which is a marker of endothelial dysfunction, and cause a profound depression of fibrinolytic activity [53]. TRL remnants also promote an enhanced thrombogenic tendency by increasing circulating factor VII levels [54].…”

Section: Effect Of Postprandial Triglyceridemia On Endothelial Dysfunmentioning

confidence: 99%

The role of virgin olive oil components in the modulation of endothelial function

Perona

Cabello-Moruno

Ruı́z-Gutı́errez

2006

The Journal of Nutritional Biochemistry

243

152

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The endothelium is involved in many of the processes related to the development of atherosclerosis, which is considered an inflammatory disease. Actually, traditional risk factors for atherosclerosis predispose to endothelial dysfunction, which is manifested as an increase in the expression of specific cytokines and adhesion molecules. There are firm evidence supporting the beneficial effects of olive oil, the most genuine component of the Mediterranean diet. Although the effects of olive oil and other oleic acid-rich dietary oils on atherosclerosis and plasma lipids are well known, the roles of minor components have been less investigated. Minor components constitute only 1-2% of virgin olive oil (VOO) and are composed of hydrocarbons, polyphenols, tocopherols, sterols, triterpenoids and other components usually found in traces. Despite their low concentration, non-fatty acid constituents may be of importance because studies comparing monounsaturated dietary oils have reported different effects on cardiovascular disease. Most of these compounds have demonstrated antioxidant, anti-inflammatory and hypolipidemic properties. In this review, we summarize current knowledge on the effects of these compounds contained in VOO on vascular dysfunction and the mechanisms by which they modulate endothelial activity. Such mechanisms involve the release of nitric oxide, eicosanoids (prostaglandins and leukotrienes) and adhesion molecules, in most cases by activation of nuclear factor kappaB by reactive oxygen species.

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“…Elevated PAI-1 levels may be a marker of endothelial dysfunction, and cause a profound depression of fibrinolytic activity thus contributing to the pathogenesis of vascular disease. Lipolysed remnants of triglyceride-rich lipoproteins also promote an enhanced thrombogenic tendency by increasing circulating factor VII levels (39). A study by Orth, Luley and Wieland (40) demonstrated that postprandial chylomicrons and VLDL inhibit the ability of platelets to aggregate, whereas these effects were not observed for chylomicron remnants in physiological concentrations.…”

Section: Prothrombotic Changesmentioning

confidence: 99%

Induction of Atherosclerosis by Human Chylomicron Remnants: A Hypothesis

Wilhelm

Cooper

2003

JAT

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Plasma Level of Triglyceride-rich Lipoprotein Remnants Is Closely Associated with the Activation of Coagulation Factor VII in Patients with Myocardial Infarction

Cited by 10 publications

References 38 publications

Characterization of a tissue factor/factor VIIa‐dependent model of thrombosis in hypercholesterolemic rabbits

Characterization of a tissue factor/factor VIIa‐dependent model of thrombosis in hypercholesterolemic rabbits

The role of virgin olive oil components in the modulation of endothelial function

Induction of Atherosclerosis by Human Chylomicron Remnants: A Hypothesis

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