Plasma level of malondialdehyde in the cases of acute paraquat intoxication

Gil, Hyo‐Wook; Seok, Su-Jin; Jeong, Du-Shin; Yang, Jong‐Oh; Lee, Eun Young; Hong, Sae‐Yong

doi:10.3109/15563650903468803

Cited by 22 publications

(16 citation statements)

References 14 publications

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“…Plasma PQ concentration and creatinine level at admission are important prognostic markers [13]. Some oxidative stress markers have been investigated by our group and in other reports [14]–[19], but it is doubtful that these markers would be superior to plasma PQ concentration. In addition, although these markers may be involved in the pathogenesis in PQ injury, they are not useful in the clinical situation because they require expensive laboratory capabilities.…”

Section: Discussionmentioning

confidence: 92%

Prediction of Patient Survival in Cases of Acute Paraquat Poisoning

et al. 2014

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Paraquat concentration-time data have been used to predict the clinical outcome following ingestion. However, these studies have included only small populations, although paraquat poisoning has a very high mortality rate. The purpose of this study was to develop a simple and reliable model to predict survival according to the time interval post-ingestion in patients with acute paraquat poisoning. Data were retrospectively collected for patients who were admitted with paraquat poisoning to Soonchunhyang University Choenan Hospital between January 2005 and December 2012. Plasma paraquat levels were measured using high-performance liquid chromatography. To validate the model we developed, we used external data from 788 subjects admitted to the Presbyterian Medical Center, Jeonju, Korea, between January 2007 and December 2012. Two thousand one hundred thirty six patients were included in this study. The overall survival rate was 44% (939/2136). The probability of survival for any specified time and concentration could be predicted as (exp(logit))/(1+exp(logit)), where logit = 1.3544+[−3.4688×log10(plasma paraquat μg/M)]+[−2.3169×log10(hours since ingestion)]. The external validation study showed that our model was highly accurate for the prediction of survival (C statics 0.964; 95% CI [0.952–0.975]). We have developed a model that is effective for predicting survival after paraquat intoxication.

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Section: Discussionmentioning

confidence: 92%

Prediction of Patient Survival in Cases of Acute Paraquat Poisoning

et al. 2014

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“…MDA concentrations in serum and homogenized kidney tissue were determined using an assay kit (Northwest Life Science Specialties, Vancouver, Canada). is test is based on the reaction of MDA with thiobarbituric acid (TBA), which results in the production of MDA-TBA2; a compound with measurable absorbance at 532 nm [24]. Total antioxidant capacity and total oxidant status of the tissues and serum were measured by the colorimetric methods described by Erel [25,26].…”

Section: Biochemical Analysismentioning

confidence: 99%

Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats

Bozkurt¹,

Em²,

Oktayoğlu³

et al. 2014

CIM

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TurkeyCarvacrol prevents methotrexateinduced renal oxidative injury and renal damage in rats AbstractPurpose: e purpose of this study was to investigate the e ect of carvacrol (CAR) on methotrexate (MTX)-induced renal damage in rats.Methods: Twenty-four male rats were equally divided into three groups: group I, control treatment; group II, MTX-treated; and group III, MTX+CAR-treated. A single dose of CAR (73 mg/kg) was administered intraperitoneally to group III on the rst day of the experiment and a single dose of MTX (20 mg/kg) was administered intraperitoneally to groups II and III on the second day of the experiment. Blood samples and kidney tissue were obtained from each animal on day 8 for the measurement of malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI). Light microscopy was used for histopathological examination of kidney specimens.Results: MDA, TOS and OSI levels were signi cantly greater in the group receiving MTX alone relative to the control animals, while the TAS level was signi cantly reduced in the MTX group compared with the control group. e administration of CAR was associated with signi cantly decreased MDA, TOS, and OSI levels and increased TAS levels relative to the rats treated with MTX alone. Animals treated with CAR exhibited decreased tubular degeneration and architectural impairment relative to animals treated with MTX alone; however, the di erence in histological scores did not meet the threshold of statistical signi cance. e folic acid antagonist methotrexate (MTX) is used clinically to inhibit the synthesis of purines and pyrimidines [1]. MTX is commonly used at high doses to limit the growth of malignancies, but may also be used at low doses in in ammatory diseases, including psoriasis and rheumatoid arthritis, to inhibit the proliferation of in ammatory leukocytes [2][3][4]. MTX remains an essential component of modern clinical therapy for acute lymphoblastic leukemia and is the primary treatment for malignant gestational trophoblastic disease [5]. In addition to anti-proliferative activity, MTX has antiin ammatory and immunomodulatory properties; however, cytotoxic e ects and other side e ects limit the e cacy of MTX as an anti-in ammatory. Signi cant side e ects of MTX have been described in several organ systems. In particular, MTX has a detrimental e ect on kidney function [6]; however, the mechanism of MTX-induced toxicity remains unclear. More than 90% of MTX is ltered by the kidneys [7] and MTX treatment is known to cause renal failure at high doses [8]. Renal impairment can result in altered metabolism of MTX, delayed drug excretion and, subsequently, systemic toxicity. e toxic e ects of MTX are typically treated through hydration and alkalinization of the patient; however, these methods are insu cient to prevent all instances of MTX toxicity. Reactive oxygen species (ROS) have been implicated in the pathogenesis of MTX-induced renal damage [9,10]. MTX produces free oxygen radicals, resulting in enhanced li...

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“…As farmers have been able to more easily control vegetation, their crops have grown in greater quantities. However, the negative effects of herbicide use pose serious social issues in Asian countries (1-4). Farmers sometimes accidentally or willfully swallow toxic concentrations of herbicides, which results in death or severe detrimental effects.…”

Section: Introductionmentioning

confidence: 99%

Cellular Toxicity of Surfactants Used as Herbicide Additives

et al. 2012

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The cellular toxicities of surfactants, a solvent, and an antifreeze that are included in herbicide formulations were assessed by measuring their effects on membrane integrity, metabolic activity, mitochondrial activity, and total protein synthesis rate in a cell culture. Polyethylene glycol, propylene glycol, and monoethylene glycol exhibited no cellular toxicity even at a high concentration of 100 mM. Sodium lauryl ether sulfate and polyoxyethylene lauryl ether significantly damaged the membrane, disturbed cellular metabolic activity, and decreased mitochondrial activity and the protein synthesis rate; however, their toxicity was far below those of the severely toxic chemicals at comparable concentrations. The severely toxic category included polyoxypropylene glycol block copolymer, polyoxyethylene tallow amine, and polyoxyethylene lauryl amine ether. These surfactants were cytotoxic between 3.125 µM and 100 µM in a dose-dependent manner. However, the toxicity graph of concentration vs toxicity had a point of inflection at 25 µM. The slope of the toxicity graph was gentle when the concentration was below 25 µM and steep when the concentration was greater than 25 µM. In conclusion, our results suggest that the toxicity of surfactants be taken care of pertinent treatment of acute herbicide intoxication.

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Plasma level of malondialdehyde in the cases of acute paraquat intoxication

Abstract: Both cross-sectional and sequential measurements of plasma MDA do not provide reliable information on outcome in patients with acute PQ intoxication.

Cited by 22 publications

References 14 publications

Prediction of Patient Survival in Cases of Acute Paraquat Poisoning

Prediction of Patient Survival in Cases of Acute Paraquat Poisoning

Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats

Cellular Toxicity of Surfactants Used as Herbicide Additives

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