Plasma level of lipoprotein Lp(a) is high in predialysis or hemodialysis, but not in CAPD

Kandoussi, Abdelmejid; Cachera, C; Pagniez, Dominique; Dracon, M; Fruchart, Jean Charles; Tacquet, A

doi:10.1038/ki.1992.304

Cited by 52 publications

(22 citation statements)

References 8 publications

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“…The restoration of renal function after the graft leads rapidly to a significant decrease in Lp(a) concentrations in CAPD as in hemodialysis patients. Concerning CAPD patients, conflicting results were reported by our previous study [7]in which we had found normal Lp(a) values. The extremely wide range of Lp(a) plasma levels and its highly skewed distribution may explain this discrepancy particularly when the sample sizes are small.…”

Section: Discussioncontrasting

confidence: 41%

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Apo(a) Phenotypes and Lp(a) Concentrations in Renal Transplant Patients

Kandoussi

Hugue²,

Cachera³

et al. 1998

Nephron

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Plasma lipoprotein (a) (LP(a)) concentrations are increased in patients with end-stage renal disease. Considering the influence of the apolipoprotein (a) (Apo(a)) polymorphism and the mode of dialysis in this prospective longitudinal study, we compared Lp(a) concentrations before and after the first 6 months of a successful kidney transplantation in 125 recipient patients. Apo(a) phenotyping was performed by using SDS-PAGE and SDS-agarose, isoforms were classified into high molecular weight (HMW) and low molecular weight (LMW). Before the graft, the Lp(a) concentrations were significantly higher in CAPD than in hemodialysis patients (p = 0.021). Six months after transplantation, Lp(a) fell in both treatment groups. This decrease occurred within both LMW and HMW but to a different extent: median relative variations were –35 and –50%, respectively (p = 0.048). Among patients with Lp(a) concentration >30 mg/dl 6 months after transplantation, 74% had LMW Apo(a) isoform while the remaining 26% had HMW isoform. Successful renal transplantation leads rapidly to a correction of Lp(a) concentrations, especially in patients treated with CAPD who have higher Lp(a) levels. The most important factor seems to be the LMW status corresponding to high Lp(a) levels.

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Section: Discussioncontrasting

confidence: 41%

“…There are several reports of increased Lp(a) plasma concentrations in chronic renal failure patients [5, 6, 7]. After renal transplantation, results are not uniform, and it was concluded that renal function and/or cyclosporine therapy could influence the Lp(a) concentration [8].…”

Section: Introductionmentioning

confidence: 99%

Apo(a) Phenotypes and Lp(a) Concentrations in Renal Transplant Patients

Kandoussi

Hugue²,

Cachera³

et al. 1998

Nephron

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“…8 Dialysis therapy may increases Lp(a) 10 or decreases Lp(a) level. 8,11 Some studies also reported that Lp(a) level did not vary before and after hemodialysis. 5,12 In our study we find elevated levels of Lp(a) in CRF patients with and without hemodialysis as compared to controls.…”

Section: Discussionmentioning

confidence: 99%

“…6 Controversies exist regarding Lp(a) levels in CRF patients with and without hemodialysis. There are few studies that showed Lp(a) levels were elevated in CRF patients, 7,8,9 Lp(a) levels were elevated in hemodialysed patients, 10 Lp(a) levels were decreased after hemodialysis 8,11 and Lp(a) levels did not vary before and after hemodialysis. 5,12 With the implication of plasma lipids and lipoproteins in the pathogenesis of atherosclerosis and ischemic heart disease, it becomes worthwhile to study the behavior of various lipid fractions in CRF patients.…”

Section: Introductionmentioning

confidence: 99%

Lipid profile and lipoprotein(a) in chronic renal failure patients with and without hemodialysis

Sharma¹,

Shah²,

Gorasia

et al. 2012

IJMEDPH

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Objectives: Chronic renal failure (CRF) is complicated by characteristic dyslipidemias. CRF patients on hemodialysis have abnormalities in lipid profile and have a high incidence of cardiovascular diseases. Lipoprotein(a) [Lp(a)] is now considered as a novel cardiovascular risk factor and its level is increased in CRF patients with and without hemodialysis. We sought to evaluate the pattern of lipid profile including Lp(a) level in CRF patients with and without hemodialysis. Methodology: Study were divided into 3 groups, Group-I: healthy controls (30), Group-II: CRF patients who never undergone hemodialysis (30) and Group-III: CRF patients on hemodialysis for more than 6 months (30). We obtained serum samples from patients in the morning after an overnight fast and were analysed for total cholesterol (TC), triglycerides (TGs), HDL, LDL, Lp(a) using standard colorimetric assays on fully automated analyzer. VLDL concentration was calculated using Friedewald's Formula. Results: Among the various parameters tested triglyceride and VLDL levels were significantly higher in group-II and III as compared to controls (p<0.01). HDL levels were significantly lower in group-II and III as compared to control (p<0.05). HDL level was found reduced in group-III as compared to Group-II (p<0.01). There was no significant change (p>0.05) observed in total cholesterol and LDL levels in between healthy controls and CRF patients with & without hemodialysis. Lp(a) levels were significantly higher in group-II and III as compared to controls (p<0.01) but the difference between Lp(a) levels in group-II and III was found insignificant (p>0.05). There was no significant difference (p>0.05) observed between Lp(a) levels and lipid profile in male and female patients in control group and in CRF patients with and without hemodialysis. Conclusions: This study demonstrated that CRF patients with and without hemodialysis are at greater risk of development of dyslipidemias, characterized by hypertriglyceridemia, elevated VLDL and Lp(a) levels and decreased HDL levels. Total cholesterol and LDL cholesterol levels remain normal or decreased in these patients. Both male and female patients of CRF with and without hemodialysis have dyslipidemias without any discrimination of sex and it is not attenuated by the hemodialysis process.

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“…Even though predialysis patients exhibit high serum Lp(a) levels [5, 6], there are sparse data with regard to serum Lp(a) concentrations in patients with mild/moderate renal failure [7, 8]. …”

Section: Introductionmentioning

confidence: 99%