Plasma level of LDL-cholesterol at diagnosis is a predictor factor of breast tumor progression

Abstract

Background: Among women, breast cancer (BC) is the leading cancer and the most common cause of cancer-related death between 30 and 69 years. Although lifestyle and diet are considered to have a role in global BC incidence pattern, the specific influence of dyslipidemia in BC onset and progression is not yet completely understood.

The effect of preoperative serum triglycerides and high-density lipoprotein-cholesterol levels on the prognosis of breast cancer

“…Regarding high density serum lipoproteins, some prospective studies showed that low level can increase breast cancer risk [17,18] and high level may be a protective effect in premenopausal patient [19]; while other studies revealed that a positive correlation between high level and breast cancer risk [20]. Regarding low density serum lipoproteins, it has been reported that high level at diagnosis was associated with poor disease free survival [21]. The aim of this study was to investigate the prognostic value of serum lipids and lipoproteins in patients of breast cancer.…”

Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human Vγ9Vδ2 T Cells

“…Although many factors could underlie the inter-individual variation of Vγ9Vδ2 T-cell activities, studies indicate that metabolic resources, namely lipids such as cholesterol, could affect Vγ9Vδ2 T-cell activation and functions (23)(24)(25)(26)(27). Cholesterol, an essential component of membranes, regulates membrane fluidity and thus affects various receptor-mediated signal transduction pathways.…”

Fish Oil Supplementation Enhances Pulmonary Strength and Endurance in Women Undergoing Chemotherapy

“…LDL cholesterol is significantly associated with the progression of breast cancer (40). A high plasma concentration of LDL cholesterol at the time of diagnosis is associated with larger tumors or a more advanced stage (40). The patients involved in the present study did not present significant changes along the 60 days of the study.…”

“…However, others have noted an inverse association between total cholesterol concentrations and incidence of breast cancer in premenopausal women (38) and protective effect of high concentrations against the incidence of breast cancer (39). LDL cholesterol is significantly associated with the progression of breast cancer (40). A high plasma concentration of LDL cholesterol at the time of diagnosis is associated with larger tumors or a more advanced stage (40).…”