Plasma Leptin and the Risk of Cardiovascular Disease in the West of Scotland Coronary Prevention Study (WOSCOPS)

Wallace, Andrew M.; McMahon, Alex D.; Packard, Chris J.; Kelly, Anne; Shepherd, James; Gaw, Allan; Sattar, Naveed

doi:10.1161/hc5001.101061

Cited by 767 publications

(618 citation statements)

References 34 publications

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“…However, in our study, CRP was significantly correlated with leptin concentrations. This association, which was not observed after adjustment for BF in multivariate regression analysis, is in agreement with previous studies [13,41,43] and suggests that, in addition to leptin, another factor altered in obesity may be involved in the obesityinduced increase in CRP.…”

Section: Discussionsupporting

confidence: 92%

“…In addition, plasma leptin concentrations are raised in patients with congestive heart failure [10] and correlate with heart rate in heart transplant recipients [11]. Moreover, some authors have proposed hyperleptinemia as a component of a metabolic syndrome of cardiovascular risk [12] while others have shown that leptin is an independent risk factor for coronary events in hypercholesterolemic men [13].…”

Section: Introductionmentioning

confidence: 99%

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Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors

Gómez-Ambrosi

Salvador

Páramo

et al. 2002

Clinical Biochemistry

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Objectives: Recent epidemiologic studies have shown that obesity is associated with elevated blood concentrations of prothromboticproinflammatory factors and markers of endothelial dysfunction such as fibrinogen, C-reactive protein (CRP), von Willebrand factor (vWF), and homocysteine. We have assessed whether these markers are associated with percentage of body fat (BF), insulin sensitivity as well as with leptin concentrations. Design and methods: Twenty-five men aged 49.6 Ϯ 12.7 yr (mean Ϯ SD) underwent whole-body air displacement plethysmography (Bod-Pod ® ) for estimating BF. Blood analyses for leptin and several other metabolic and cardiovascular markers were carried out. Results: Obese subjects had higher levels as compared to controls of BF (37.5 Ϯ 5.1 vs. 26.0 Ϯ 6.6, p Ͻ 0. Conclusions: Increased BF and impaired insulin sensitivity are associated with increased concentrations of cardiovascular risk factors. Leptin seems to be involved in this elevation and emerges as a predictor of circulating fibrinogen concentrations.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors

Gómez-Ambrosi

Salvador

Páramo

et al. 2002

Clinical Biochemistry

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“…8,11,12 According to this, changes of leptin values correlated significantly to the changes of insulin resistance index (HOMA) in the 1-y period in multiple linear regression analysis adjusted for age, gender, and degree of overweight. The exact interaction between insulin and leptin are not fully elucidated.…”

Section: Discussionmentioning

confidence: 74%

“…SOB-R levels, which are decreased in obesity, 4,8,9 are postulated to play an important role in the pathophysiology of energy homeostasis. 6,10 Furthermore, not only associations between leptin and insulin resistance Fthe major complication of obesity determining morbidity and mortality [11][12][13] F but also the relationship between sOB-R and insulin resistance is being discussed. 14,15 Thus, understanding the regulation of circulating sOB-R in humans may have important physiological and therapeutical implications for human obesity and its complications.…”

Section: Introductionmentioning

confidence: 99%

Circulating soluble leptin receptor, leptin, and insulin resistance before and after weight loss in obese children

Reinehr

Kratzsch

Kieß³

et al. 2005

Int J Obes

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OBJECTIVE:To study the relationships between leptin, soluble leptin receptor (sOB-R), and insulin resistance in obese children before and after weight reduction. METHODS: We determined fasting serum leptin, sOB-R, and insulin resistance index (Homeostasis model assessment (HOMA)) in 36 obese children at baseline and 1 y later and compared them to 72 lean children matched for age, gender, and pubertal stage. The changes of leptin (Dleptin) and sOB-R (DsOB-R) over the 1 y period were correlated to the changes of HOMA (DHOMA), the changes of weight status, and the changes of percentage body fat (D%BF) based on skinfold measurements. Multiple linear regression analyses were conducted for the dependent variables Dleptin and DsOB-R, including DBMI and DHOMA as independent variables adjusted for age, gender, and pubertal stage. Changes of leptin and sOB-R levels were analyzed in 11 obese children after they had lost weight substantially (decrease SDS-BMI40.5) and compared to 11 obese children without substantial weight loss matched for age, gender, and pubertal stage. RESULTS: Obese children showed significantly (Po0.001) higher leptin and lower sOB-R levels. Dleptin correlated significantly to DSDS-BMI (r ¼ 0.28, Po0.05), D%BF (r ¼ 0.44, Po0.05), and DHOMA (r ¼ 0.42, Po0.01), while DsOB-R correlated significantly to DSDS-BMI (r ¼ À0.42, Po0.01) and D%BF (r ¼ À0.47, Po0.01), but not to DHOMA. In contrast to DsOB-R, Dleptin correlated significantly to DHOMA (P ¼ 0.02) in multiple linear regression analysis. Substantial weight loss led to a significant increase in sOB-R (P ¼ 0.02) and to a decrease in HOMA (P ¼ 0.02). In children without substantial weight loss, there were no changes in sOB-R, while HOMA (P ¼ 0.04) and leptin (P ¼ 0.02) increased significantly. CONCLUSIONS: The decrease of sOB-R and the increase of leptin levels in obese children normalized after weight loss. Therefore, these changes are consequences rather than the cause of overweight. In contrast to sOB-R, leptin levels are associated with insulin resistance.

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“…8 Accordingly, a strong association between leptin plasma levels and increased risk of myocardial infarction and stroke has been reported. 9,10 In the present study, we examined the Class I/Class II and the individual allele genotypes of the LEP-tet in patients screened for cardiovascular risk, to evaluate the role of this polymorphism as a marker for cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Microsatellite polymorphism of the human leptin gene (LEP) and risk of cardiovascular disease

et al. 2005

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Background: No data have been so far reported on the relationship between polymorphisms of LEP gene and cardiovascular disease. Patients and methods: We genotyped a tetranucleotide repeat mapped in the 3 0 UTR of the LEP gene (LEP-tet) in 109 subjects with cardiovascular events and in 109 control subjects. Results: Univariate analysis and multivariate logistic regression analysis adjusted for age, gender, smoking status, history of hyperlipidemia, hypertension or diabetes showed not significant association between the genotype of the LEP-tet and cardiovascular diseases. Moreover, no differences were observed in the plasma leptin concentrations between cases and control subjects (22719 vs 22714 ng/ml, P ¼ 0.52) and in relation to the LEP-tet classes or carriage of specific allelels (P ¼ 0.76 for the association between LEP-tet classes and leptin levels in overall analysis). Conclusions: In conclusion, our data do not support an association between the LEP-tet microsatellite polymorphism of the human LEP gene and cardiovascular diseases.

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Plasma Leptin and the Risk of Cardiovascular Disease in the West of Scotland Coronary Prevention Study (WOSCOPS)

Cited by 767 publications

References 34 publications

Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors

Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors

Circulating soluble leptin receptor, leptin, and insulin resistance before and after weight loss in obese children

Microsatellite polymorphism of the human leptin gene (LEP) and risk of cardiovascular disease

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