Plasma Leptin and Alzheimer Protein Pathologies Among Older Adults
Seunghoon Lee,
Min Soo Byun,
Dahyun Yi
et al.
Abstract:ImportanceMany epidemiologic studies have suggested that low levels of plasma leptin, a major adipokine, are associated with increased risk of Alzheimer disease (AD) dementia and cognitive decline. Nevertheless, the mechanistic pathway linking plasma leptin and AD-related cognitive decline is not yet fully understood.ObjectiveTo examine the association of plasma leptin levels with in vivo AD pathologies, including amyloid-beta (Aβ) and tau deposition, through both cross-sectional and longitudinal approaches am… Show more
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