Plasma Lecithin:Cholesterol Acyltransferase Activity and the Lipoprotein Abnormalities of Liver Disease

Harry, David; Day, R. C.; Owen, James S.; Agorastos, J.; Foo, A Y; McIntyre, Neil

doi:10.3109/00365517809104930

Cited by 16 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, APOA1 and APOA2 are the main components of high-density lipoprotein, while APOB is the main component of low-density lipoproteins (LDLs) and very low-density lipoproteins. LCAT converts free cholesterol in serum into cholesterol esters that can be stored in high-density lipoprotein and then transported to the liver for further metabolism ( 58 ). APOB is the recognition site of the LDL receptor on the plasma membrane, and a functional study using human HepG2 cells showed that enhanced cholesterol metabolism in hepatocytes stimulates the secretion of APOB and reduces the uptake of LDL ( 59 ).…”

Section: Discussionmentioning

confidence: 99%

In-Depth Serum Proteomics Reveals the Trajectory of Hallmarks of Cancer in Hepatitis B Virus–Related Liver Diseases

Xu¹,

Xu²,

Yin³

et al. 2023

Molecular & Cellular Proteomics

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

In-Depth Serum Proteomics Reveals the Trajectory of Hallmarks of Cancer in Hepatitis B Virus–Related Liver Diseases

Xu¹,

Xu²,

Yin³

et al. 2023

Molecular & Cellular Proteomics

View full text Add to dashboard Cite

“…On the other hand, there is no clear-cut correlation between plasma vitamin E and the various serum lipid fractions; this finding is not in acc ordance with previous reports on hyperlipemic patients (10) and control subjects (11,12). Thi s ma y be due to the fact that the intraintestin al bile salt deficiency and the re sulting poor vitamin E ab sorption are independent of the mechanism s responsible for the lipid disorders in chol estatic patients (13).…”

Section: Discussioncontrasting

confidence: 69%

Plasma Vitamin E Levels in Children with Cholestasis

Alvarez,

Cresteil,

Lemonnier

et al. 1984

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

SummaryPlasma vitamin levels were assayed in 58 children presenting with chronic cholestasis. In the infants who developed cholestasis during the first weeks of life, vitamin E levels dropped below normal values after the age of 4 months. In the older children, vitamin E levels were not correlated with the etiology of cholestasis but with the degree of cholestasis, as expressed by serum bilirubin, serum bile acids, and fat absorption coefficient. We did not find any relationship between vitamin E levels and other biological parameters such as alkaline phosphatases, triglycerides, phospholipids, and cholesterol. These results further support the importance of vitamin E deficiency in chronic cholestasis of infants and children.

show abstract

“…While enzyme activities were not measured in this study, it is likely that reductions in LCAT activity contribute to the development of LP-Z. Previous studies support the hypothesis that LCAT, CETP, HL, apoA-I and apoA-IV are reduced in patients with liver disease and cirrhosis [ 7 , 15 , 26 , 27 , 29 ]. Typical of patients with liver diseases, the high bilirubin samples exhibited low HDL-C and HDL particles.…”

Section: Discussionmentioning

confidence: 69%

“…These lipid changes may be explained by differences in the levels and activities of key proteins that regulate lipoprotein metabolism in subjects with liver disease. For example, patients with severe liver disease have lower circulating LCAT, cholesteryl ester transfer protein (CETP) and higher HL than healthy subjects [ 15 , 25 , 27 ], raising the possibility that defective lipoprotein remodeling and catabolism may account for the appearance of LP-Z. This is in contrast to elevated LCAT activity in subjects with non-alcoholic fatty liver disease (NAFLD), normal bilirubin levels and mildly elevated liver enzymes [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Characterization of LP-Z Lipoprotein Particles and Quantification in Subjects with Liver Disease Using a Newly Developed NMR-Based Assay

Bedi

Garcia

Jeyarajah

et al. 2020

JCM

View full text Add to dashboard Cite

Background: Lipoprotein particles with abnormal compositions, such as lipoprotein X (LP-X) and lipoprotein Z (LP-Z), have been described in cases of obstructive jaundice and cholestasis. The study objectives were to: (1) develop an NMR-based assay for quantification of plasma/serum LP-Z particles, (2) evaluate the assay performance, (3) isolate LP-Z particles and characterize them by lipidomic and proteomic analysis, and (4) quantify LP-Z in subjects with various liver diseases. Methods: Assay performance was assessed for linearity, sensitivity, and precision. Mass spectroscopy was used to characterize the protein and lipid content of isolated LP-Z particles. Results: The assay showed good linearity and precision (2.5–6.3%). Lipid analyses revealed that LP-Z particles exhibit lower cholesteryl esters and higher free cholesterol, bile acids, acylcarnitines, diacylglycerides, dihexosylceramides, lysophosphatidylcholines, phosphatidylcholines, triacylglycerides, and fatty acids than low-density lipoprotein (LDL) particles. A proteomic analysis revealed that LP-Z have one copy of apolipoprotein B per particle such as LDL, but less apolipoprotein (apo)A-I, apoC3, apoA-IV and apoC2 and more complement C3. LP-Z were not detected in healthy volunteers or subjects with primary biliary cholangitis, primary sclerosing cholangitis, autoimmune hepatitis, or type 2 diabetes. LP-Z were detected in some, but not all, subjects with hypertriglyceridemia, and were high in some subjects with alcoholic liver disease. Conclusions: LP-Z differ significantly in their lipid and protein content from LDL. Further studies are needed to fully understand the pathophysiological reason for the enhanced presence of LP-Z particles in patients with cholestasis and alcoholic liver disease.

show abstract

Plasma Lecithin:Cholesterol Acyltransferase Activity and the Lipoprotein Abnormalities of Liver Disease

Cited by 16 publications

References 16 publications

In-Depth Serum Proteomics Reveals the Trajectory of Hallmarks of Cancer in Hepatitis B Virus–Related Liver Diseases

In-Depth Serum Proteomics Reveals the Trajectory of Hallmarks of Cancer in Hepatitis B Virus–Related Liver Diseases

Plasma Vitamin E Levels in Children with Cholestasis

Characterization of LP-Z Lipoprotein Particles and Quantification in Subjects with Liver Disease Using a Newly Developed NMR-Based Assay

Contact Info

Product

Resources

About