Plasma Lead Concentration and Risk of Late Kidney Allograft Failure: Findings From the TransplantLines Biobank and Cohort Studies

Sotomayor, Camilo G.; Giubergia, Flavia; Groothof, Dion; Ferreccio, Catterina; Nolte, Ilja M.; Navis, Gerjan; Gomes-Neto, António W; Kremer, Daan; Eisenga, Michele F.; Rodrigo, Ramón; Bakker, Stephan J. L.; Damman, Kevin; Meijer, Vincent E de; Porte, Robert J.; Boer, Marieke T. de; Leuvenink, Henri; Pol, Robert A.; Annema, Coby; Ranchor, Adelita V.; Siebelink, Marion J.; Lexmond, Willem S.; Hepkema, Bouke; Pelt, L. Joost van; Gan, C. Tji-Joong; Verschuuren, Erik; Bodewes, Frank; Dijkstra, Gerard; Blokzijl, Hans; Niesters, Bert H.G.M.; Sanders, Jan-Stephan F.; Grootjans, Heleen; Douwes, Rianne M.; Slart, Riemer H. J. A.; Erasmus, Michiel E.; Leer-Buter, Coretta van; Londen, Marco van; Timens, Wim; Diepstra, Arjan; Heuvel, Marius C. van den; Knobbe, Tim J.; Schutten, Joëlle C; Swarte, Cas; Weersma, Rinse K.; Touw, Daan; Heiner-Fokkema, Rebecca; Vos, Michel J.; Klont, Frank

doi:10.1053/j.ajkd.2021.10.009

Cited by 7 publications

(6 citation statements)

References 46 publications

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“…Recent observations have raised major concerns regarding the nephrotoxicity of heavy metals, especially in populations with kidney disease, such as KTR [ 3 , 4 , 5 ]. Recent studies have shown that circulating plasma concentrations of heavy metals such as lead, cadmium, and arsenic were all independently associated with graft failure, even at concentrations that are generally considered to be within the normal range [ 3 , 4 , 5 ]. We therefore studied associations of the circulating concentration of another toxic heavy metal, thallium, in the same cohort of KTR as these aforementioned studies.…”

Section: Discussionmentioning

confidence: 99%

“…Data in this cohort included a broad variety of biochemical parameters, questionnaires, and anthropological measurements. Notably, these analyses were performed on the same population that recent studies had shown evidence of nephrotoxicity due to cadmium, lead, and arsenic [ 3 , 4 , 5 ]. For the current study, participants without available samples for plasma thallium measurements were excluded.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, the search for potential modifiable causes of graft failure is ongoing. Heavy metal-induced nephrotoxicity may be a potential cause of kidney graft failure that is often overlooked, yet it has gained international attention in the past years [ 2 , 3 , 4 , 5 ]. While the nephrotoxic effect of circulating high concentrations of heavy metals is well-established [ 6 ], the KTR population may already be vulnerable to nephrotoxicity at concentrations that would otherwise be considered within the normal range.…”

Section: Introductionmentioning

confidence: 99%

“…Clearly, these circumstances greatly limit the resilience of the kidney’s ability to handle additional unfavorable factors, such as exposure to heavy metals. Indeed, it was recently found that high-normal circulating concentrations of heavy metals, including cadmium, lead, and arsenic are independently associated with a higher risk of graft failure in KTR [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Plasma Thallium Concentration, Kidney Function, Nephrotoxicity and Graft Failure in Kidney Transplant Recipients

Kremer

Riemersma

Groothof

et al. 2022

JCM

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The nephrotoxic effects of heavy metals have gained increasing scientific attention in the past years. Recent studies suggest that heavy metals, including cadmium, lead, and arsenic, are detrimental to kidney transplant recipients (KTR) even at circulating concentrations within the normal range, posing an increased risk for graft failure. Thallium is another highly toxic heavy metal, yet the potential consequences of the circulating thallium concentrations in KTR are unclear. We measured plasma thallium concentrations in 672 stable KTR enrolled in the prospective TransplantLines Food and Nutrition Biobank and Cohort Study using inductively coupled plasma mass spectrometry. In cross-sectional analyses, plasma thallium concentrations were positively associated with kidney function measures and hemoglobin. We observed no associations of thallium concentration with proteinuria or markers of tubular damage. In prospective analyses, we observed no association of plasma thallium with graft failure and mortality during a median follow-up of 5.4 [interquartile range: 4.8 to 6.1] years. In conclusion, in contrast with other heavy metals such as lead, cadmium, and arsenic, there is no evidence of tubular damage or thallium nephrotoxicity for the range of circulating thallium concentrations observed in this study. This is further evidenced by the absence of associations of plasma thallium with graft failure and mortality in KTR.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Plasma Thallium Concentration, Kidney Function, Nephrotoxicity and Graft Failure in Kidney Transplant Recipients

Kremer

Riemersma

Groothof

et al. 2022

JCM

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“…Even relatively low cadmium levels in patients with CKD were associated with the progression to end-stage renal disease [ 41 , 42 ]. Furthermore, our group has found in KTRs that exposure to relatively low concentrations of cadmium and lead was associated with a substantially increased risk of developing graft failure [ 43 , 44 ]. KTRs can be particularly susceptible to toxic agents due to concomitant diseases (e.g., diabetes and cardiovascular disease), reduced kidney function, and adherence to immunosuppressive therapy.…”

Section: Heavy Metals and The Kidneymentioning

confidence: 99%

Iron Deficiency and Nephrotoxic Heavy Metals: A Dangerous Interplay?

Rawee

Kremer

Nolte

et al. 2023

IJMS

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Heavy metals are common in our environment, and all individuals are exposed to them to some extent. These toxic metals have several harmful effects on the body, including the kidney, which is a very sensitive organ. Indeed, heavy metal exposure has been linked to an increased risk of chronic kidney disease (CKD) and its progression, which may be explained by the well-established nephrotoxic effects of these metals. In this hypothesis and narrative literature review, we will shed light on the potential role that another highly common problem in patients with CKD, iron deficiency, may play in the damaging effects of heavy metal exposure in this patient group. Iron deficiency has previously been linked with an increased uptake of heavy metals in the intestine due to the upregulation of iron receptors that also take up other metals. Furthermore, recent research suggests a role of iron deficiency in the retention of heavy metals in the kidney. Therefore, we hypothesize that iron deficiency plays a crucial role in the damaging effects of heavy metal exposure in patients with CKD and that iron supplementation might be a strategy to combat these detrimental processes.

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Microalgae-based natural oral hydrogel system for synergistic treatment of lead poisoning-related diseases

Liu,

Ye,

Hua

et al. 2023

Nano Today

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Plasma Lead Concentration and Risk of Late Kidney Allograft Failure: Findings From the TransplantLines Biobank and Cohort Studies

Cited by 7 publications

References 46 publications

Plasma Thallium Concentration, Kidney Function, Nephrotoxicity and Graft Failure in Kidney Transplant Recipients

Plasma Thallium Concentration, Kidney Function, Nephrotoxicity and Graft Failure in Kidney Transplant Recipients

Iron Deficiency and Nephrotoxic Heavy Metals: A Dangerous Interplay?

Microalgae-based natural oral hydrogel system for synergistic treatment of lead poisoning-related diseases

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