Plasma Kisspeptin Levels in Pregnancies with Diabetes and Hypertensive Disease as a Potential Marker of Placental Dysfunction and Adverse Perinatal Outcome

Ćetković, Aleksandar; Miljić, Dragana; Ljubić, Aleksandar; Patterson, Michael; Ghatei, Mohammad A.; Stamenkovic, Jelena; Nikolic-Djurovic, Marina; Pekić, Sandra; Doknic, Mirjana; Glišić, Andreja; Bloom, Stephen R.; Popović, Vera

doi:10.3109/07435800.2011.639319

Cited by 61 publications

(56 citation statements)

References 28 publications

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“…Therefore, the higher circulating kisspeptin levels during normal pregnancy may play a physiological role to enhance insulin secretion to protect the mother and foetus from increasing glucose levels and the development of gestational diabetes mellitus. In keeping with this hypothesis, pregnant women with diabetes have lower kisspeptin levels than pregnant women without diabetes 47. In addition, previous rodent work has shown that selective ablation of the kisspeptin receptor, kiss1r , from pancreatic islet β‐cells in pregnant mice results in impaired glucose tolerance and reduced insulin secretion 48.…”

Section: Discussionmentioning

confidence: 74%

The effects of kisspeptin on β‐cell function, serum metabolites and appetite in humans

Izzi‐Engbeaya

Comninos

Clarke

et al. 2018

Diabetes Obesity Metabolism

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AimsTo investigate the effect of kisspeptin on glucose‐stimulated insulin secretion and appetite in humans.Materials and methodsIn 15 healthy men (age: 25.2 ± 1.1 years; BMI: 22.3 ± 0.5 kg m−2), we compared the effects of 1 nmol kg−1 h−1 kisspeptin versus vehicle administration on glucose‐stimulated insulin secretion, metabolites, gut hormones, appetite and food intake. In addition, we assessed the effect of kisspeptin on glucose‐stimulated insulin secretion in vitro in human pancreatic islets and a human β‐cell line (EndoC‐βH1 cells).ResultsKisspeptin administration to healthy men enhanced insulin secretion following an intravenous glucose load, and modulated serum metabolites. In keeping with this, kisspeptin increased glucose‐stimulated insulin secretion from human islets and a human pancreatic cell line in vitro. In addition, kisspeptin administration did not alter gut hormones, appetite or food intake in healthy men.ConclusionsCollectively, these data demonstrate for the first time a beneficial role for kisspeptin in insulin secretion in humans in vivo. This has important implications for our understanding of the links between reproduction and metabolism in humans, as well as for the ongoing translational development of kisspeptin‐based therapies for reproductive and potentially metabolic conditions.

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Section: Discussionmentioning

confidence: 74%

The effects of kisspeptin on β‐cell function, serum metabolites and appetite in humans

Izzi‐Engbeaya

Comninos

Clarke

et al. 2018

Diabetes Obesity Metabolism

View full text Add to dashboard Cite

show abstract

“…15 On the other hand, it has been shown that ablation of dynorphin causes increase of fatty acid oxidation in male mice, reduction in adiposity, and increased weight loss during fasting, probably due to decreases in intestinal nutrient absorption. 16 There has been no study performed about neurokinin B in relation with insulin resistance, or glucose intolerance, and dynorphin does not seem to essentially affect glucose homeostasis.…”

Section: Onset Of Adolescence Tanner Staging and Glucose Metabolismmentioning

confidence: 99%

Prediabetes and Adolescence—Trends, Causes, Effects, and Screening

Stefanaki¹

2016

US Endocrinology

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Intermediate hyperglycemia, or prediabetes, is increasing worldwide, affecting people of all ages, including adolescents. Hormonal, physiological, psychological, and lifestyle changes in adolescence have been associated with disruptions in glucose homeostasis, such as decreased insulin sensitivity, insulin resistance, or the combination of both. As a rule, glucose homeostasis is ameliorated, in normal subjects, when puberty is completed. However, in susceptible individuals, like obese adolescents, or adolescents with a strong genetic background, there is a progression to type 2 diabetes onset. Thus, susceptible adolescents should be screened for prediabetes, using fasting plasma glucose, and glycated hemoglobin (HbA 1c ), and oral glucose tolerance testing. Prediabetic adolescents should be counseled for a healthy lifestyle including healthy dietary habits, increased physical activity, and/or stress management. Other pathological conditions should be adequately treated. Early recognition of prediabetes in adolescence will prevent type 2 diabetes onset, decreasing the diabetes-associated health burden in adult life. This review aims to revise the associations and elucidate on the gaps between prediabetes and adolescence, via a comprehensive review of the current medical literature.

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“…However, the authors suggested that both series of results reflect the determining role that kisspeptin plays in moderating implantation in the first trimester. Other studies have replicated these findings, with Armstrong and coworkers finding lower circulating kisspeptin values at 16-20 weeks' gestation in patients who subsequently developed pre-eclampsia and intrauterine growth restriction (Armstrong et al 2009) and Cetovic and coworkers demonstrating significantly lower circulating kisspeptin in pregnancies affected by type 1 diabetes, pre-eclampsia, gestational hypertension and gestational diabetes (Cetovic et al 2012).…”

Section: Implantation and Placental Functionmentioning

confidence: 82%

Kisspeptin across the human lifespan:evidence from animal studies and beyond

Clarke

Dhillo

2016

Journal of Endocrinology

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Since its first description in 1996, the KISS1 gene and its peptide products, kisspeptins, have increasingly become recognised as key regulators of reproductive health. With kisspeptins acting as ligands for the kisspeptin receptor KISS1R (previously known as GPR54 or KPR54), recent work has consistently shown that administration of kisspeptin across a variety of species stimulates gonadotrophin release through influencing gonadotrophin-releasing hormone secretion. Evidence from both animal and human studies supports the finding that kisspeptins are crucial for ensuring healthy development, with knockout animal models, as well as proband genetic testing in human patients affected by abnormal pubertal development, corroborating the notion that a functional kisspeptin receptor is required for appropriate gonadotrophin secretion. Given the large body of evidence that exists surrounding the influence of kisspeptin in a variety of settings, this review summarises our physiological understanding of the role of these important peptides and their receptors, before proceeding to describe the varying role they play across the reproductive lifespan.

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Plasma Kisspeptin Levels in Pregnancies with Diabetes and Hypertensive Disease as a Potential Marker of Placental Dysfunction and Adverse Perinatal Outcome

Cited by 61 publications

References 28 publications

The effects of kisspeptin on β‐cell function, serum metabolites and appetite in humans

The effects of kisspeptin on β‐cell function, serum metabolites and appetite in humans

Prediabetes and Adolescence—Trends, Causes, Effects, and Screening

Kisspeptin across the human lifespan:evidence from animal studies and beyond

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