Plasma Kinetics, Excretion in Milk and Tissue Levels in the Cow following Implantation of Trenbolone Acetate®

Pottier, J.; Busigny, M.; Grandadam, J. A.

doi:10.2527/jas1975.413962x

Cited by 45 publications

(18 citation statements)

References 2 publications

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“…In the current study, the influence of the anabolic combination trenbolone acetate plus estradiol on gene expression in liver of Nguni heifers was investigated. It is generally known that the effect of the anabolic combination Revalor H is consistent during an experimental period as in the present trial (21) and also the actual measurement of the plasma progesterone levels showed a significant difference between the control and the treatment with the most distinct differences at days 22-39 proving the effectiveness of Revalor H until the end of the experimental course. Progesterone levels were lower in the treatment group compared to the control group due to negative feedback mechanisms following the application of exogenous hormones.…”

Section: Discussionmentioning

confidence: 54%

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Effect of trenbolone acetate plus estradiol on transcriptional regulation of metabolism pathways in bovine liver

Becker¹,

Riedmaier²,

Reiter³

et al. 2010

Hormone Molecular Biology and Clinical Investigation

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Several biochemical pathways showed different regulations on mRNA level under the influence of trenbolone acetate plus estradiol. The inhibition of nutrient metabolism and protein breakdown seems to support growth processes. IGF-1 plays an important role in growth and development and thus the upregulation of IGF-1 could be responsible for the stimulation of growth in treated animals. The upregulation of IGF-1 could also be revealed as a possible risk factor for the generation of artherosclerotic plaques, which are known as long-term side effects following the use of anabolic steroids. Principal components analysis of RT-qPCR results showed that both groups arrange together and can be clearly separated. Therefore, these might be used as possible biomarkers in bovine liver.

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Section: Discussionmentioning

confidence: 54%

“…Several investigations showed its efficacy in cattle and the beneficial effect on meat quality and quantity (20). In addition, the activity of this combination on day 42 has been proven, as the intended effect is persistent up to day 105 after implantation and residues of the applied drug are detectable in blood up to day 90 (21).…”

Section: Introductionmentioning

confidence: 98%

Effect of trenbolone acetate plus estradiol on transcriptional regulation of metabolism pathways in bovine liver

Becker¹,

Riedmaier²,

Reiter³

et al. 2010

Hormone Molecular Biology and Clinical Investigation

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“…Similarly, the reduced prostate enlargement associated with TREN appears to result from the presence of a 3-oxotriene structure that prevents A-ring reduction of this steroid (46), ultimately limiting its ability to undergo 5␣-reduction or aromatization. As a result, trenbolone is primarily metabolized to its less potent 17␣-isoform (epitrenbolone) or trendione in humans (55) and in other mammalian species (17,31,45,46), underlying its equal potency in tissues that highly express 5␣-reductase (e.g., prostate) vs. those that do not (e.g., skeletal muscle) (67).…”

Section: E657mentioning

confidence: 99%

17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone) exhibits tissue selective anabolic activity: effects on muscle, bone, adiposity, hemoglobin, and prostate

Yarrow

Conover

McCoy

et al. 2011

American Journal of Physiology-Endocrinology and Metabolism

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Yarrow JF, Conover CF, McCoy SC, Lipinska JA, Santillana CA, Hance JM, Cannady DF, VanPelt TD, Sanchez J, Conrad BP, Pingel JE, Wronski TJ, Borst SE. 17␤-Hydroxyestra-4,9,11-trien-3-one (trenbolone) exhibits tissue selective anabolic activity: effects on muscle, bone, adiposity, hemoglobin, and prostate. Am J Physiol Endocrinol Metab 300: E650 -E660, 2011; First published January 25, 2011; doi:10.1152/ajpendo.00440.2010.-Selective androgen receptor modulators (SARMs) now under development can protect against muscle and bone loss without causing prostate growth or polycythemia. 17␤-Hydroxyestra-4,9,11-trien-3-one (trenbolone), a potent testosterone analog, may have SARM-like actions because, unlike testosterone, trenbolone does not undergo tissue-specific 5␣-reduction to form more potent androgens. We tested the hypothesis that trenbolone-enanthate (TREN) might prevent orchiectomy-induced losses in muscle and bone and visceral fat accumulation without increasing prostate mass or resulting in adverse hemoglobin elevations. Male F344 rats aged 3 mo underwent orchiectomy or remained intact and were administered graded doses of TREN, supraphysiological testosterone-enanthate, or vehicle for 29 days. In both intact and orchiectomized animals, all TREN doses and supraphysiological testosterone-enanthate augmented androgen-sensitive levator ani/ bulbocavernosus muscle mass by 35-40% above shams (P Յ 0.001) and produced a dose-dependent partial protection against orchiectomy-induced total and trabecular bone mineral density losses (P Ͻ 0.05) and visceral fat accumulation (P Ͻ 0.05). The lowest doses of TREN successfully maintained prostate mass and hemoglobin concentrations at sham levels in both intact and orchiectomized animals, whereas supraphysiological testosteroneenanthate and high-dose TREN elevated prostate mass by 84 and 68%, respectively (P Ͻ 0.01). In summary, low-dose administration of the non-5␣-reducible androgen TREN maintains prostate mass and hemoglobin concentrations near the level of shams while producing potent myotrophic actions in skeletal muscle and partial protection against orchiectomy-induced bone loss and visceral fat accumulation. Our findings indicate that TREN has advantages over supraphysiological testosterone and supports the need for future preclinical studies examining the viability of TREN as an option for androgen replacement therapy.

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“…Results from experiments in vitro suggest that TBA is able to reduce both basal and ACTH-stimulated corticosterone production (Thomas & Rodway, 1983). The lowest dose of trenbolone, the active component of TBA (Pottier, Busigny & Grandadam, 1975), used in these experiments was Ì0~7mol/1 which elicited a 42 and 31% reduction in basal and ACTH-stimulated corticosterone production respectively. Concentrations of trenbolone measured in sheep plasma in vivo have been found to be somewhat lower (approx.…”

Section: Discussionmentioning

confidence: 99%

Effects of trenbolone acetate on adrenal function and hepatic enzyme activities in female rats

Thomas¹,

Rodway²

1983

Journal of Endocrinology

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The effects of the anabolic steroid trenbolone acetate (TBA) on adrenal function and hepatic enzyme activity have been studied in growing female rats. Treatment with TBA resulted in a decrease in the peak of plasma corticosterone concentration which occurred during the afternoon. The enzymes tyrosine aminotransferase (TAT) and phosphoenolpyruvate carboxykinase were measured in the livers of treated and control rats. Activities of both enzymes were maximal at 22.00 h, but that of TAT was reduced in TBA-treated rats. After injection of ACTH, TBA-treated rats showed a smaller increase in plasma corticosterone than did controls. Treatment with TBA did not affect the induction of TAT activity after corticosterone treatment. All TBA-treated rats grew significantly faster than controls and the possible relevance of this reduced adrenal function to the increased growth rate is discussed.

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Plasma Kinetics, Excretion in Milk and Tissue Levels in the Cow following Implantation of Trenbolone Acetate®

Cited by 45 publications

References 2 publications

Effect of trenbolone acetate plus estradiol on transcriptional regulation of metabolism pathways in bovine liver

Effect of trenbolone acetate plus estradiol on transcriptional regulation of metabolism pathways in bovine liver

17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone) exhibits tissue selective anabolic activity: effects on muscle, bone, adiposity, hemoglobin, and prostate

Effects of trenbolone acetate on adrenal function and hepatic enzyme activities in female rats

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