Plasma insulin-like growth factor-I concentrations increase during the estrous phase in goats

Hashizume, Takumi; Ohtsuki, K; Matsumoto, N

doi:10.1016/s0739-7240(99)00082-x

Cited by 27 publications

(34 citation statements)

References 28 publications

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“…Our study also observed a sharp increase in IGF-I about the time of ovulation in cows that cycled normally. This is similar to the high IGF-I at estrus in goats reported by Hashizume et al [19]. These findings suggest that normal follicular development may be associated with an early rise in IGF-I postpartum.…”

Section: Discussionsupporting

confidence: 90%

“…The mean number of days from parturition to cyst diagnosis was 22.2 ± 3.0 (range [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] in cows that spontaneously developed cysts. The mean number of days from parturition to first ovulation postpartum in the cows that had persistent CL was 23.1 ± 2.2 (range 15-33) and 17.5 ± 0.7 (range [15][16][17][18][19][20] in cows that cycled normally within 20 days postpartum.…”

Section: Resultsmentioning

confidence: 99%

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Relationship among Insulin-Like Growth Factor-I, Blood Metabolites and Postpartum Ovarian Function in Dairy Cows

Zulu

Sawamukai

Nakada

et al. 2002

The Journal of Veterinary Medical Science

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ABSTRACT. The relationship among nutritional status, systemic insulin-like growth factor-I (IGF-I) and ovarian function early postpartum were investigated. A total of 27 Holstein-Friesian cows, 10 that cycled normally within 20 days postpartum, 5 diagnosed with follicular cysts, 8 with persistent corpus luteum (CL) after the first ovulation postpartum and 4 with inactive ovaries were used for the study. Blood samples were collected 1-3 times per week, for 60 days pre-and postpartum, for IGF-I, progesterone, estradiol, free fatty acids (FFA), blood urea nitrogen (BUN), and aspartate aminotransferase (AST) determination. Inactive ovary and cystic cows had a higher body condition score before calving and lost more condition than normal or persistent CL cows. Immediately postpartum, IGF-I levels were higher and rose sharply in cows that cycled normally than in cystic, inactive ovary or persistent CL cows. At calving and early postpartum, FFA was higher in inactive ovary and cystic than in normal and persistent CL cows. There was a significant strong positive relationship between IGF-I and BUN, and strong negative relationships between IGF-I and FFA and AST in all groups. There was a positive relationship between serum IGF-I and estradiol in normal cystic and inactive ovary cows. This study found that overconditioned cows during the dry period or at calving, lost more body condition postpartum. These cows also had a deeper and longer period of negative energy balance (NEB), poor liver function and low circulating IGF-I concentrations early postpartum. Such cows were likely to have poor reproductive function as seen in development of cystic ovaries, persistent CL and inactive ovary. Changes in serum IGF-I early postpartum may help predict both nutritional and reproductive status in dairy cattle.

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Section: Discussionsupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Relationship among Insulin-Like Growth Factor-I, Blood Metabolites and Postpartum Ovarian Function in Dairy Cows

Zulu

Sawamukai

Nakada

et al. 2002

The Journal of Veterinary Medical Science

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“…Increase in plasma IGF-I may be associated with ovulation. Burns et al [16] observed a one-day rise in IGF-I after estrus in cattle and Hashizume et al [41] found increased levels during estrus in goats. Zulu et al [96] made similar observations, reporting a sharp increase in IGF-I around the time of first ovulation postpartum.…”

Section: Igf-i and Hypothalamo-pituitary Functionmentioning

confidence: 99%

Insulin-Like Growth Factor-I as a Possible Hormonal Mediator of Nutritional Regulation of Reproduction in Cattle

Zulu

Nakao

Sawamukai

2002

The Journal of Veterinary Medical Science

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ABSTRACT. The current review aims to establish insulin-like growth factor-1 (IGF-I) as the factor that signals nutritional status to the reproductive axis, and show that assessment of IGF-I in blood early postpartum during the negative energy balance (NEB) period could be used to predict both nutritional and reproductive status in dairy cattle. The review also explores the effect of nutritional status on circulating IGF-I concentrations and the endocrine role of IGF-I on the reproductive axis. IGF-I plays an important role in gonadotropininduced folliculogenesis, ovarian steroidogenesis and corpus luteum (CL) function. It also modulates pituitary and hypothalamus function. IGF-I clearly has an endocrine role on the reproductive axis. Severe under nutrition significantly reduces plasma IGF-I concentrations. During the critical period of NEB in high yielding dairy cattle early postpartum, IGF-I concentrations are low in blood and its levels are positively correlated to energy status and reproductive function during this period. Changes in circulating IGF-I immediately postpartum may help predict both nutritional and reproductive status in dairy cattle. IGF-I is therefore one of the long sought factors that signal nutritional status to the reproductive axis.

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“…Furthermore, this study showed that IGF-I concentrations increased from Day 7 to Day 9, suggesting that increase of IGF-I secretion may be associated with rise of estradiol at the follicular phase. It has previously been reported in beef cows and goats that IGF-I concentrations in the blood increase on the day of estrus [15,16], and that estradiol enhances the IGF-I concentrations in ovariectomized animals [17][18][19]. Interestingly, the main source of the rise in IGF-I caused by estradiol may be the uterus in goats [19].…”

Section: Discussionmentioning

confidence: 93%

Relations between Plasma IGF-I Concentrations during Treatment with CIDR-based or Ovsynch Protocol for Timed AI and Conception in Early Postpartum Japanese Black Beef Cows

Kawate

Sakase

Seo

et al. 2006

Journal of Reproduction and Development

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Abstract. We examined the relations between plasma insulin-like growth factor (IGF) -I concentrations during treatment with CIDR-based or Ovsynch protocol for timed AI and conception and plasma steroid concentrations in early postpartum Japanese Black beef cows. Cows in the control group (Ovsynch; n=21) underwent Ovsynch protocol (GnRH analogue on Day 0, PGF2α analogue on Day 7, and GnRH analogue on Day 9), with AI on Day 10, approximately 20 h after the second GnRH treatment. Cows in the Ovsynch+CIDR group (n=22) received Ovsynch protocol plus a CIDR for 7 days (starting on Day 0). Cows in the further treatment group (EB+CIDR+GnRH; n=22) received 2 mg of estradiol benzoate (EB) on Day 0 in lieu of the first GnRH treatment, followed by the same treatment as in the Ovsynch+CIDR protocol. Plasma IGF-I concentrations were determined on Days -7, 0, 7, 9 and 17. Conception rates were improved in the CIDR-combined groups (both CIDR-treated groups were combined) relative to Ovsynch group (P<0.05) for cows with low IGF-I concentrations (<1,000 ng/ml) on Days -7, 0, and 7, but improved conception rate produced by the CIDR-based protocols did not occur in cows with a high IGF-I concentration (≥1,000 ng/ml). Plasma estradiol-17β concentrations increased from Day 0 to 7 (P<0.05) and were unchanged from Day 7 to 9 in the Ovsynch group with low IGF-I concentrations on Day 0, while they were unchanged from Day 0 to 7 and increased from Day 7 to 9 (P<0.05) in the Ovsynch group with high IGF-I concentrations on Day 0 and in the CIDR-combined group. Plasma progesterone concentrations in the Ovsynch group with low IGF-I concentrations on Day 0 were higher on Day 14 than in the Ovsynch group with high IGF-I concentrations on Day 0 and in the CIDR-combined group (P<0.05). In conclusion, CIDR-based protocols may improve conception relative to Ovsynch in early postpartum beef cows with lower plasma IGF-I concentrations at the start of the protocols. This improvement is probably due to prevention of premature increases of estradiol-17β and progesterone concentrations, which occurred in cows with low IGF-I concentrations treated with Ovsynch, by the CIDR treatment.

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Plasma insulin-like growth factor-I concentrations increase during the estrous phase in goats

Cited by 27 publications

References 28 publications

Relationship among Insulin-Like Growth Factor-I, Blood Metabolites and Postpartum Ovarian Function in Dairy Cows

Relationship among Insulin-Like Growth Factor-I, Blood Metabolites and Postpartum Ovarian Function in Dairy Cows

Insulin-Like Growth Factor-I as a Possible Hormonal Mediator of Nutritional Regulation of Reproduction in Cattle

Relations between Plasma IGF-I Concentrations during Treatment with CIDR-based or Ovsynch Protocol for Timed AI and Conception in Early Postpartum Japanese Black Beef Cows

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