Plasma insulin-like growth factor-1 (IGF-1) concentrations in human breast cancer

Peyrat, Jean‐Philippe; Louchez, M M; Lefèbvre, Jean Louis; Bonneterre, Jacques; Vennin, Philippe; Demaille, A; Helquet, B.; Fournier, Charles

doi:10.1016/s0959-8049(05)80137-6

Cited by 258 publications

(165 citation statements)

References 26 publications

Supporting

Mentioning

156

Contrasting

Unclassified

Order By: Relevance

“…Epidemiologic evidence is suggesting a possible role of IGFs in promoting and IGFBPs in suppressing breast carcinogenesis. Higher levels of IGF-1 were associated with breast cancer both in pre-and post-menopausal women in one study (Peyrat et al, 1993) and only in premenopausal women in two other studies (Bruning et al, 1995;Bohlke et al, 1998) where lower levels of IGFBP-3 were also found in premenopausal cases compared to controls. No associations were observed for these variables and breast cancer in postmenopausal women in two other investigations (Bruning et al, 1995;Hankinson et al, 1997) and in one study on premenopausal women (Del Giudice et al, 1998), although in the latter the control group chosen, potentially at high risk.…”

Section: Glycemic Index In Chronic Disease Ls Augustin Et Almentioning

confidence: 89%

Glycemic index in chronic disease: a review

et al. 2002

View full text Add to dashboard Cite

Aim: The intent of this review is to critically analyze the scientific evidence on the role of the glycemic index in chronic Western disease and to discuss the utility of the glycemic index in the prevention and management of these disease states. Background: The glycemic index ranks foods based on their postprandial blood glucose response. Hyperinsulinemia and insulin resistance, as well as their determinants (eg high energy intake, obesity, lack of physical activity) have been implicated in the etiology of diabetes, coronary heart disease and cancer. Recently, among dietary factors, carbohydrates have attracted much attention as a significant culprit, however, different types of carbohydrate produce varying glycemic and insulinemic responses. Low glycemic index foods, characterized by slowly absorbed carbohydrates, have been shown in some studies to produce beneficial effects on glucose control, hyperinsulinemia, insulin resistance, blood lipids and satiety. Method: Studies on the short and long-term metabolic effects of diets with different glycemic indices will be presented and discussed. The review will focus primarily on clinical and epidemiological data, and will briefly discuss in vitro and animal studies related to possible mechanisms by which the glycemic index may influence chronic disease.

show abstract

Section: Glycemic Index In Chronic Disease Ls Augustin Et Almentioning

confidence: 89%

Glycemic index in chronic disease: a review

et al. 2002

View full text Add to dashboard Cite

show abstract

“…A further association is provided by studies demonstrating serum GH concentrations to be elevated in a significant percentage of breast cancer patients compared to controls 59 and also to be increased in women at high risk for familial breast cancer 60 . Circulating levels of IGF-1 have been found to be increased in women with breast cancer compared to control subjects 61 . That these elevated levels of IGF-1 are not due to the cancer itself is discounted by a study by A further paper has also shown mammographic density to be positively associated with IGF-1, negatively with IGF-2, but not with IGFBP-3.…”

Section: The Role Of the Gh-igf-1 Axis In Breast Cancermentioning

confidence: 99%

The GH–IGF-I axis and breast cancer

Laban

Bustin

Jenkins

2003

Trends in Endocrinology & Metabolism

109

View full text Add to dashboard Cite

“…102 Mechanisms point to associations between obesity and/or upper body adiposity with decreased levels of sex hormone bonding globulin, 103,104 hyperinsulinemia, and correspondingly higher levels of insulin-like growth factor type I. 105,106 In studies that included large numbers of African American women, obesity has also been shown to be associated with larger tumors, positive lymph nodes, and later stage at diagnosis. 30,98,107 Of relevance to this discussion, Jones et al showed that, in multivariate analyses, 30% of the later stage at diagnosis observed in African American women relative to white women could be attributed to the greater prevalence of severe obesity in this population.…”

Section: Obesitymentioning

confidence: 99%