Plasma Insulin-Like Growth Factor-1 (IGF-1), IGF-Binding Protein-3, and the Risk of Prostate Cancer: A Matched Case-Control Study in a Korean Population

Kim, Jeong Hyun; Park, Kwan Jin; Bae, Jun Ho; Yeo, Woon Geol; Byun, Seok‐Soo; Lee, Eun Sik

doi:10.4111/kju.2009.50.7.642

Cited by 1 publication

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“…In total, 59 studies were included in this meta-analysis, consisting of 18 prospective and 41 retrospective studies. Nine studies had not been included in the Rowlands 2012 paper [ 129 , 133 , 134 , 142 , 147 , 148 , 152 – 154 ] and eight studies that were included in the Rowlands 2012 analysis were excluded due to critical RoB [ 175 – 178 , 180 – 183 ]. Data were extracted for all five IGF and IGFBP peptides.…”

Section: Resultsmentioning

confidence: 99%

Does milk intake promote prostate cancer initiation or progression via effects on insulin-like growth factors (IGFs)? A systematic review and meta-analysis

Harrison

Lennon

Holly

et al. 2017

Cancer Causes Control

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PurposeTo establish whether the association between milk intake and prostate cancer operates via the insulin-like growth factor (IGF) pathway (including IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3).MethodsSystematic review, collating data from all relevant studies examining associations of milk with IGF, and those examining associations of IGF with prostate cancer risk and progression. Data were extracted from experimental and observational studies conducted in either humans or animals, and analyzed using meta-analysis where possible, with summary data presented otherwise.ResultsOne hundred and seventy-two studies met the inclusion criteria: 31 examining the milk–IGF relationship; 132 examining the IGF–prostate cancer relationship in humans; and 10 animal studies examining the IGF–prostate cancer relationship. There was moderate evidence that circulating IGF-I and IGFBP-3 increase with milk (and dairy protein) intake (an estimated standardized effect size of 0.10 SD increase in IGF-I and 0.05 SD in IGFBP-3 per 1 SD increase in milk intake). There was moderate evidence that prostate cancer risk increased with IGF-I (Random effects meta-analysis OR per SD increase in IGF-I 1.09; 95% CI 1.03, 1.16; n = 51 studies) and decreased with IGFBP-3 (OR 0.90; 0.83, 0.98; n = 39 studies), but not with other growth factors. The IGFBP-3 -202A/C single nucleotide polymorphism was positively associated with prostate cancer (pooled OR for A/C vs. AA = 1.22; 95% CI 0.84, 1.79; OR for C/C vs. AA = 1.51; 1.03, 2.21, n = 8 studies). No strong associations were observed for IGF-II, IGFBP-1 or IGFBP-2 with either milk intake or prostate cancer risk. There was little consistency within the data extracted from the small number of animal studies. There was additional evidence to suggest that the suppression of IGF-II can reduce tumor size, and contradictory evidence with regards to the effect of IGFBP-3 suppression on tumor progression.ConclusionIGF-I is a potential mechanism underlying the observed associations between milk intake and prostate cancer risk.Electronic supplementary materialThe online version of this article (doi:10.1007/s10552-017-0883-1) contains supplementary material, which is available to authorized users.

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