Plasma Inorganic Fluoride Concentrations After Sevoflurane Anesthesia in Children

Levine, Mark; Sarner, J. B.; Lerman, Jerrold; Davis, Peter J.; Sikich, Nancy; Maloney, Karen; Motoyama, Etsuro K.; Cook, David

doi:10.1097/00132586-199706000-00020

Cited by 6 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…24 The plasma concentration of inorganic fluoride, an in vivo metabolite of sevoflurane, was found to be low [less than 50 μmol/L (1.02 ppm) theoretical threshold for nephrotoxicity] in children after sevoflurane anesthesia and was eliminated rapidly, and the children scheduled for elective surgery were unlikely to be at risk for nephrotoxicity from high fluoride levels. 25 In our study, the serum inorganic fluoride levels were also low (less than the theoretical threshold for nephrotoxicity). Similar to our results, the serum inorganic fluoride levels were even lower in the cyanotic group than in the acyanotic group.…”

Section: Time Groupssupporting

confidence: 39%

The Effects of Sevoflurane Anesthesia and Cardiopulmonary Bypass on Renal Function in Cyanotic and Acyanotic Children Undergoing Cardiac Surgery

Akıncı

Kanbak

et al. 2011

Renal Failure

View full text Add to dashboard Cite

Background: There are few data on the effects of anesthesia and cardiopulmonary bypass (CPB) on perioperative renal function in children with cyanotic congenital heart disease undergoing open heart surgery. This study aims to investigate the perioperative renal function in cyanotic versus acyanotic children undergoing sevoflurane anesthesia for open heart surgery. Methods: After receiving ethical committee approval, 12 acyanotic patients (preoperative oxygen saturation: SaO 2 > 85%) and 12 cyanotic children (SaO 2 < 85%) were included. Sevoflurane was administered at concentration levels of 2% before CPB and 1-2% during CPB after standard anesthesia induction. Inorganic fluoride, electrolytes, creatinine, urea nitrogen in serum and urine samples, and N-acetyl-β-D-glucosaminidase (NAG) in urine samples were measured before induction, before CPB, during CPB, after CPB, at the end of surgery, and at 24th h postoperatively. Results: The levels of serum uric acid levels were higher in the cyanotic group (p < 0.05). There were no differences in the levels of serum creatinine and urine creatinine, urea nitrogen, and electrolytes between the two groups. Serum inorganic fluoride levels were always higher in the acyanotic group than in the cyanotic group, but these differences between the groups reached statistical significance at two measurement times (before CPB and end of surgery) (p < 0.05). Urinary inorganic fluoride levels increased with time in both groups. Although urinary NAG increased significantly after the CPB in the cyanotic group, the differences between the two groups did not reach statistical significance. Conclusions: We have concluded that renal function was not affected during open heart surgery with sevoflurane anesthesia, in both cyanotic and acyanotic children.

show abstract

Section: Time Groupssupporting

confidence: 39%

The Effects of Sevoflurane Anesthesia and Cardiopulmonary Bypass on Renal Function in Cyanotic and Acyanotic Children Undergoing Cardiac Surgery

Akıncı

Kanbak

et al. 2011

Renal Failure

View full text Add to dashboard Cite

show abstract

“…In addition to muscle relaxants and opioids, Dr Cook studied the pharmacology of naloxone and volatile anesthetics and helped define their role in pediatric anesthesia and perhaps in patients with organ failure. Pharmacokinetic data were determined using assays developed by Dr Richard Stiller, who joined the enterprise in the early 1980s.…”

Section: Era Of Clinical Pharmacologymentioning

confidence: 99%

The advancement of pediatric anesthesia pharmacology: David Ryan Cook (scions, serendipity, and six degrees of separation)

Cladis

Christine

Yaster

et al. 2018

Pediatric Anesthesia

View full text Add to dashboard Cite

Summary Dr David Ryan Cook, Professor Emeritus of Anesthesiology and Pharmacology at the University of Pittsburgh and Chief of Anesthesiology at Children's Hospital of Pittsburgh (1977‐1999), is a pioneer in the field of pediatric anesthesiology and pharmacology. Dr Cook contributed significantly to the understanding of pharmacologic differences among infants, children, and adults. His work as a clinician‐scientist, educator, and mentor defined the pharmacology of many of the anesthetic agents we continue to use today. He brought science to the art of anesthesia and enhanced the safety of pediatric perioperative care. Based on a 2017 interview with Dr Cook, this article outlines the development of his career and his contributions to the field of anesthesiology and pharmacology.

show abstract

“…hexafluoroisopropanol (HFIP) [33], or changes in renal plasma flow. More recently, it has been observed that maximum fluoride concentrations do not exceed 20 mmol.l 21 in children undergoing sevoflurane anaesthesia and they are therefore unlikely to be at risk from renal toxicity [34,35]. Despite some early misgivings [33], sevoflurane is now well established as the agent of choice for inhalational induction in both adults and children.…”

Section: Fluoridementioning

confidence: 99%

Anions and the anaesthetist

2002

View full text Add to dashboard Cite

SummaryAnions are the negative components of most chemical structures and play many important physiological and pharmacological roles that are of interest to the anaesthetist. Their relevance is reviewed with a particular emphasis on the inorganic anions (halides, bicarbonate, phosphate and sulphate) and the significance and limitations of the anion gap. Organic anions (albumin, lactate) are also discussed, albeit briefly. The suitability of anions for their role in neurotransmission and acid2base balance is outlined.

show abstract

Plasma Inorganic Fluoride Concentrations After Sevoflurane Anesthesia in Children

Cited by 6 publications

References 0 publications

The Effects of Sevoflurane Anesthesia and Cardiopulmonary Bypass on Renal Function in Cyanotic and Acyanotic Children Undergoing Cardiac Surgery

The Effects of Sevoflurane Anesthesia and Cardiopulmonary Bypass on Renal Function in Cyanotic and Acyanotic Children Undergoing Cardiac Surgery

The advancement of pediatric anesthesia pharmacology: David Ryan Cook (scions, serendipity, and six degrees of separation)

Anions and the anaesthetist

Contact Info

Product

Resources

About