Plasma IL-36α and IL-36γ as Potential Biomarkers in Interstitial Lung Disease Associated with Rheumatoid Arthritis: a Pilot Study in the Chinese Population

Zheng, Weishuai; Hu, Xingxing; Zou, Menglin; Nie, Hongtao; Song, Weiwei; Wang, Rui; Liu, Ying; Hou, Qinhui; Liu, Yuan; Chen, Xiaoqi; Cheng, Zhenshun

doi:10.1007/s10753-022-01733-x

Cited by 7 publications

(4 citation statements)

References 34 publications

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“…A previous cohort study utilized data from the Medical Data Vision claims database in Japan that included 718 patients with GPP and 27,773 with plaque psoriasis; focusing on the prevalence of comorbidities, medication use, and healthcare resource utilization, the results showed a higher incidence of interstitial pneumonia [ 95 ]. Although the direct relationship between GPP-related IL-36 and lung disease remains unclear, another study examined the role of IL-36 cytokines in rheumatoid arthritis related interstitial lung disease (RA-ILD) [ 96 ]. It found that plasma concentrations of IL-36α and IL-36γ were higher in RA-ILD patients compared to healthy controls and RA patients without ILD [ 96 ], suggesting a possible role of IL-36 in lung diseases.…”

Section: Lung Disease In Gppmentioning

confidence: 99%

“…Although the direct relationship between GPP-related IL-36 and lung disease remains unclear, another study examined the role of IL-36 cytokines in rheumatoid arthritis related interstitial lung disease (RA-ILD) [ 96 ]. It found that plasma concentrations of IL-36α and IL-36γ were higher in RA-ILD patients compared to healthy controls and RA patients without ILD [ 96 ], suggesting a possible role of IL-36 in lung diseases.…”

Section: Lung Disease In Gppmentioning

confidence: 99%

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Generalized Pustular Psoriasis and Systemic Organ Dysfunctions

Teshima,

Saito-Sasaki,

Sawada

2024

IJMS

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This review explores the intricate relationship between generalized pustular psoriasis (GPP) and various systemic diseases, shedding light on the broader impacts of this severe skin condition beyond its primary dermatological manifestations. GPP is identified as not only a profound contributor to skin pathology but also a significant risk factor for systemic diseases affecting cardiovascular, hepatic, renal, pulmonary, and skeletal systems, as well as associated with an increased incidence of anemia, depression, anxiety, and arthritis. The research highlights the complex interplay of cytokines, particularly IL-17 and IL-36, which are central to the pathophysiology of GPP and implicated in the exacerbation of systemic conditions. Key findings indicate a higher incidence of cardiovascular events in GPP patients compared to those with other severe forms of psoriasis, notably with a stronger correlation between myocardial infarction history and GPP development. Liver disturbances, frequently reversible upon psoriasis remission, suggest a cytokine-mediated link to hepatic health. Renal dysfunction appears elevated in GPP sufferers, with IL-17 and IL-36 potentially driving renal fibrosis. Similarly, interstitial lung disease and osteoporosis in GPP patients underscore the systemic reach of inflammatory processes initiated in the skin. The associations with anemia, depression, anxiety, and arthritis further complicate the clinical management of GPP, requiring a multidisciplinary approach. The study concludes that managing GPP effectively requires a holistic approach that addresses both the cutaneous and systemic dimensions of the disease, advocating for continued research into the mechanisms that connect GPP with broader health implications to refine therapeutic strategies.

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Section: Lung Disease In Gppmentioning

confidence: 99%

Section: Lung Disease In Gppmentioning

confidence: 99%

Generalized Pustular Psoriasis and Systemic Organ Dysfunctions

Teshima,

Saito-Sasaki,

Sawada

2024

IJMS

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“…Markers of pulmonary vasculopathy, such as vascular cell adhesion molecule 1 (VCAM-1), monocyte chemoattractant protein 1 (MCP-1), and asymmetric dimethylarginine (ADMA), have been reported as useful biomarkers of ILD in RA patients and can help in the differential diagnosis of RA-ILD from IPF [ 108 ]. Other reported biomarkers include endothelin-1 [ 109 ], interleukin 13, 18 [ 107 ], 36a and 36γ [ 110 ], and HE4 [ 111 ]. It appears that patients with RA-ILD have short telomeres compared to other CTD-ILDs, and they have worse outcomes in terms of survival and lung function than the other CTD-ILDs, suggesting that telomere length plays an important prognostic role in this disease [ 112 ].…”

Section: Biomarkers For Acute Exacerbations Of Connective Tissue Dise...mentioning

confidence: 99%

Acute Exacerbations of Interstitial Lung Diseases: Focus on Biomarkers

Drakopanagiotakis

Markart

Steiropoulos

2023

IJMS

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Interstitial lung diseases (ILDs) are a large group of pulmonary disorders characterized histologically by the cardinal involvement of the pulmonary interstitium. The prototype of ILDs is idiopathic pulmonary fibrosis (IPF), an incurable disease characterized by progressive distortion and loss of normal lung architecture through unchecked collagen deposition. Acute exacerbations are dramatic events during the clinical course of ILDs, associated with high morbidity and mortality. Infections, microaspiration, and advanced lung disease might be involved in the pathogenesis of acute exacerbations. Despite clinical scores, the prediction of the onset and outcome of acute exacerbations is still inaccurate. Biomarkers are necessary to characterize acute exacerbations better. We review the evidence for alveolar epithelial cell, fibropoliferation, and immunity molecules as potential biomarkers for acute exacerbations of interstitial lung disease.

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“…Plasma levels of IL-36α and IL-36γ were higher in RA patients with interstitial lung disease (RA-ILD) compared to those in healthy controls or RA patients without ILD ( Table 1 ). 67 Rheumatoid arthritis-ILD patients with usual interstitial pneumonia pattern (UIP) showed more plasma levels of IL-36γ than that in RA-ILD patients without UIP. Rheumatoid arthritis patients complicated with systemic lupus erythematosus (SLE) revealed elevated serum levels of IL-36α and IL-36γ than those in patients with SLE.…”

Section: Introductionmentioning

confidence: 97%

Role of IL-1 Family Cytokines IL-36, IL-37, IL-38 in Osteoarthritis and Rheumatoid Arthritis: A Comprehensive Review

Xu,

Wang,

Zou

et al. 2024

JIR

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Plasma IL-36α and IL-36γ as Potential Biomarkers in Interstitial Lung Disease Associated with Rheumatoid Arthritis: a Pilot Study in the Chinese Population

Cited by 7 publications

References 34 publications

Generalized Pustular Psoriasis and Systemic Organ Dysfunctions

Generalized Pustular Psoriasis and Systemic Organ Dysfunctions

Acute Exacerbations of Interstitial Lung Diseases: Focus on Biomarkers

Role of IL-1 Family Cytokines IL-36, IL-37, IL-38 in Osteoarthritis and Rheumatoid Arthritis: A Comprehensive Review

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