Plasma human placental lactogen, oxytocinase, and placental phosphatase in normal and toxemic pregnancies

Spellacy, William N.; Usategui-Gomez, M.; Fernandez-deCastro, A.

doi:10.1016/0002-9378(77)90306-4

Cited by 22 publications

(8 citation statements)

References 23 publications

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“…However, this association was not confirmed by others [4,6,7,19,27]. Although we have found statistically significant correlations between these Parameters in our population, their dispersion was considerable.…”

Section: Discussioncontrasting

confidence: 99%

Human chorionic somatomammotropin, estriol and oxytocinase as indexes of fetal growth

Giussi¹,

Vinacur²,

Ballejo³

et al. 1979

Journal of Perinatal Medicine

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Section: Discussioncontrasting

confidence: 99%

Human chorionic somatomammotropin, estriol and oxytocinase as indexes of fetal growth

Giussi¹,

Vinacur²,

Ballejo³

et al. 1979

Journal of Perinatal Medicine

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“…This is in contrast to baboon plasma that lacks oxytocinase, at least in vitro, as reflected by the lack of oxytocin metabolism. Since oxytocinase is confined to the syncytiotrophoblastic cells of the placenta [9] and since its concentration is significantly correlated with the placental weight [10], the presence of placenta in the baboon may explain the much higher rate of oxytocin metabolic clearance rate in vivo [27] as compared with the present in vitro study. Thus, the baboon is more similar to other species such as the pregnant rat, rabbit, and sheep that lack circulating forms of oxytocinase [28].…”

Section: Discussionmentioning

confidence: 33%

“…The blood of pregnant women inactivates oxytocin due to the presence of a circulating enzyme, oxytocinase [6,7], which is a cystine aminopeptidase (CAP). CAP is produced by the placental syncytiotrophoblasts and is secreted into the maternal circulation in increasing amounts with advancing gestational age [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Oxytocin and Oxytocin Antagonist Metabolism in the Plasma of Pregnant Humans and Baboons

Song¹,

Pak³

et al. 2002

Gynecol Obstet Invest

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Oxytocin antagonists may be useful in inhibiting the uterine contractions of preterm labor. One such compound is TT-235 (previously referred to as Antag III). The purpose of this study was to compare the resistance of TT-235 and oxytocin to enzymatic degradation by oxytocinase in the blood of humans and baboons during their 3rd trimester of pregnancy. Blood samples from pregnant women and baboons not in labor were incubated in vitro with known amounts of oxytocin and TT-235. Samples were collected at 0, 15, 30, 45, and 60 min for oxytocin analysis and at 0, 10, 60, and 360 min for TT-235 analysis. Oxytocin was analyzed by radioimmunoassay after extraction, while TT-235 was analyzed by radioreceptor assay. In human blood, oxytocin was readily metabolized with >83% disappearance over the 60-min incubation period. In contrast, TT-235 was stable up to 360 min of incubation. In the baboon, oxytocin did not diminish over the 60-min incubation period. The level of TT-235 was similar to that in human blood without change over 360 min of incubation. This study suggests (1) that in contrast to blood from pregnant humans, blood from pregnant baboons lacks oxytocinase at least in vitro and (2) that TT-235 is resistant to enzymatic degradation by human blood, implying that this oxytocin antagonist may have a prolonged activity in vivo in humans.

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“…Literature data on PLAP values during complicated pregnancy are conflicting, both high [2][3][4] and low [1,9,10] values have been reported. Methodological difficulties should to some extent explain this discrepancy.…”

Section: Discussionmentioning

confidence: 99%

Placental Alkaline Phosphatase Compared with Human Placental Lactogen and Oestriol in High-Risk Pregnancies

Ronin-Walknowska¹,

Holmgren

Schoultz³

et al. 1984

Gynecol Obstet Invest

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Serum levels of placental alkaline phosphatase (PLAP), human placental lactogen (HPL) and oestriol (E₃) were investigated in 33 women with high-risk pregnancies. In pregnancies complicated by intrauterine growth retardation (IUGR) low PLAP values were constantly recorded. HPL values showed a similar pattern while E₃ levels were between normal mean and the lower limit of –2 SD. A clear differentiation between IUGR and pre-eclampsia was achieved by the simultaneous determination of PLAP and HPL. It is suggested that PLAP determinations may be more informative than E₃ to detect placental insufficiency.

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Plasma human placental lactogen, oxytocinase, and placental phosphatase in normal and toxemic pregnancies

Cited by 22 publications

References 23 publications

Human chorionic somatomammotropin, estriol and oxytocinase as indexes of fetal growth

Human chorionic somatomammotropin, estriol and oxytocinase as indexes of fetal growth

Comparison of Oxytocin and Oxytocin Antagonist Metabolism in the Plasma of Pregnant Humans and Baboons

Placental Alkaline Phosphatase Compared with Human Placental Lactogen and Oestriol in High-Risk Pregnancies

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