Plasma hsa-miR-22-3p Might Serve as an Early Predictor of Ventricular Function Recovery after ST-Elevation Acute Myocardial Infarction

Abstract

Left ventricle remodeling (LVR) after acute myocardial infarction (aMI) leads to impairment of both systolic and diastolic function, a major contributor to heart failure (HF). Despite extensive research, predicting post-aMI LVR and HF is still a challenge. Several circulant microRNAs have been proposed as LVR predictors; however, their clinical value is controversial. Here, we used real-time quantitative polymerase chain reaction (qRT-PCR) to quantify hsa-miR-22-3p (miR-22) plasma levels on the first day of hospital admission of ST-elevation aMI (STEMI) patients. We analyzed miR-22 correlation to the patients’ clinical and paraclinical variables and evaluated its ability to discriminate between post-aMI LVR and non-LVR. We show that miR-22 is an excellent aMI discriminator and can distinguish between LVR and non-LVR patients. The discriminative performance of miR-22 significantly improves the predictive power of a multiple logistic regression model based on four continuous variables (baseline ejection fraction and end-diastolic volume, CK-MB, and troponin). Furthermore, we found that diabetes mellitus, hematocrit level, and the number of erythrocytes significantly influence its levels. These data suggest that miR-22 might be used as a predictor of ventricular function recovery in STEMI patients.

Ispinesib Mesylate-induced oxidative stress via miR-30e-5p/BCL2L11 axis in acute myocardial infarction: a comprehensive bioinformatics and experimental validation investigation

“…Amidst the escalating tempo of human existence and heightened stressors across various facets of contemporary society, disorders traditionally linked to advanced age are progressively in ltrating younger demographics [21]. Pathologically, AMI is profoundly in uenced by hypoxia and apoptosis (Aptosis) [22,23,24]. Certain researchers suggest that apoptosis could potentially serve as a pivotal risk factor for AMI, potentially impeding cellular differentiation and regeneration, thereby serving as a signi cant catalyst for disease progression [25,26].…”

Novel Biomarkers and Their Role in the Diagnosis and Prognosis of Acute Coronary Syndrome

“…Measuring plasma miR-22 shortly after admission may serve as a diagnostic tool for MI and a predictor of left ventricular remodeling. However, the reliability of this approach may be influenced by factors like diabetic status and blood parameters, paving the way for further research to enhance patient care and interventions [118].…”