Plasma homocysteine levels predict early recurrence after catheter ablation of persistent atrial fibrillation

Yao, Yan; Yao, Wei; Bai, Rong; Lu, Zhenhua; Tang, Ri‐Bo; Jiang, Chen‐Xi; Sang, Caihua; Zhang, Jianqiang; Yu, Rong‐Hui; Du, Xin; Liu, Xiaohui; Ma, Changsheng

doi:10.1093/europace/euw081

Cited by 18 publications

(17 citation statements)

References 19 publications

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“…Crosssectional clinical studies indicated that AF patients had elevated homocysteine levels (16,17) and decreased vitamin B6 levels compared with controls (16), whereas a prospective epidemiological study showed no significant association of AF with homocysteine (18). Several observational clinical studies have reported the positive association of homocysteine with recurrent AF risk after ablation (19)(20)(21). Given the close relation of homocysteine with atherosclerotic CVD and AF recurrence, homocysteine may be associated with incident AF in the general population.…”

Section: Introductionmentioning

confidence: 99%

Homocysteine and Incident Atrial Fibrillation: The Atherosclerosis Risk in Communities Study and the Multi-Ethnic Study of Atherosclerosis

Kubota

Alonso

Heckbert

et al. 2019

Heart, Lung and Circulation

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Section: Introductionmentioning

confidence: 99%

Homocysteine and Incident Atrial Fibrillation: The Atherosclerosis Risk in Communities Study and the Multi-Ethnic Study of Atherosclerosis

Kubota

Alonso

Heckbert

et al. 2019

Heart, Lung and Circulation

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“…Depending on the above-described criteria of evaluation, 11 validated articles were included for analysis in our study. [5][6][7][10][11][12][13][14][15][16][17] The main characteristics of the included studies are shown in the Table. Comparisons of homocysteine levels between AF patients and control subjects: Four studies were included in the comparisons of homocysteine levels between AF patients and control subjects. The random-effects model was used since heterogeneity existed (I 2 = 92.7%, P = 0.000).…”

Section: Resultsmentioning

confidence: 99%

Elevated Homocysteine Levels Associated with Atrial Fibrillation and Recurrent Atrial Fibrillation

Rong¹,

Huang²,

Jin³

et al. 2020

Int. Heart J.

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There is increasing evidence linking plasma homocysteine levels and atrial fibrillation (AF). The association between an elevated level of plasma homocysteine and AF was examined by meta-analysis in this study. The PubMed and ScienceDirect databases until August 2019 were utilized to collect previous literature on homocysteine and the potential relation to AF. The pooled effects were evaluated depending on standardized mean differences (SMDs) or odds ratios (ORs) with 95% confidence intervals (CIs), and the calculation was performed using Stata 12 software. A total of 11 validated articles were included in the meta-analysis. For pooled effect, the results confirmed that AF patients had higher homocysteine levels than control subjects (SMD: 0.58, 95%CI: 0.09-1.06). Compared with control subjects, homocysteine levels were higher in paroxysmal AF (SMD: 0.45, 95%CI: 0.18-0.72) and persistent AF patients (SMD: 1.21, 95%CI: 0.50-1.92). The pooled analysis suggested that patients with elevated homocysteine levels had markedly higher risk of AF compared with lower homocysteine levels in the categorical variable (OR: 2.21, 95%CI: 1.16-4.21) and continuous variable analyses (OR: 1.13, 95%CI: 1.00-1.27), respectively. In addition, the pooled analysis indicated that recurrent AF patients had significantly higher homocysteine levels than those without recurrence (SMD: 0.65, 95%CI: 0.42-0.88). The pooled analysis of the categorical variables indicated that elevated homocysteine levels were associated with increased risk of AF recurrence (OR: 3.81, 95%CI: 3.11-4.68). However, the association was weak in the pooled analysis of continuous variables (OR: 1.88, 95%CI: 0.74-4.81). Our meta-analysis identified that plasma homocysteine levels were significantly elevated in AF and recurrent AF patients. Elevated homocysteine is associated with increased risk of AF and AF recurrence.

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“…5 Finally, HHcy has been associated with early recurrence of atrial tachyarrhythmia after procedure of catheter ablation, representing a predictor of early recurrence of atrial fibrillation. 6 As recently highlighted by Spence et al, 7 these observations may be of particular clinical relevance. In fact, in patients undergoing cardiac surgery who developed HHcy, an appropriate homocysteine-lowering treatment with folic acid and methylcobalamin may contribute to prevent atrial fibrillation development, thus improving the outcome of these subjects.…”

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confidence: 84%

Postoperative atrial fibrillation and ischemic stroke: The role of homocysteine

Acampa

Lazzerini

Martini

2017

European Stroke Journal

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Plasma homocysteine levels predict early recurrence after catheter ablation of persistent atrial fibrillation

Abstract: Plasma Hcy levels are associated with early recurrence of atrial tachyarrhythmia after catheter ablation in persistent atrial fibrillation patients, thus it should be taken into account in prediction of early recurrence.

Cited by 18 publications

References 19 publications

Homocysteine and Incident Atrial Fibrillation: The Atherosclerosis Risk in Communities Study and the Multi-Ethnic Study of Atherosclerosis

Homocysteine and Incident Atrial Fibrillation: The Atherosclerosis Risk in Communities Study and the Multi-Ethnic Study of Atherosclerosis

Elevated Homocysteine Levels Associated with Atrial Fibrillation and Recurrent Atrial Fibrillation

Postoperative atrial fibrillation and ischemic stroke: The role of homocysteine

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