Plasma homocysteine levels in obese and non-obese subjects with or without hypertension; its relationship with oxidative stress and copper

Konukoğlu, Dildar; Özden, Sibel; Ercan, Meltem; Turhan, Mehtap Sultan

doi:10.1016/s0009-9120(03)00059-6

Cited by 63 publications

(56 citation statements)

References 13 publications

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“…Namely, it has been suggested that obesity may be associated with increased plasma homocysteine levels. [20][21][22][23] Obesity is frequently accompanied by OSA and the presence of OSA can explain several abnormalities traditionally ascribed to obesity. 25 In this present study we, however, have shown that occult OSA is unlikely to explain any association between obesity and hyperhomocysteinaemia.…”

Section: Discussionmentioning

confidence: 99%

“…24 Because of consistent data showing increased homocysteine in obese individuals, [20][21][22][23] we also calculated a homocysteine/BMI ratio in all subjects.…”

Section: Methodsmentioning

confidence: 99%

“…Both smoking and obesity may affect homocysteine levels. [19][20][21][22][23] Last, many subjects in the prior study were on some kind of medication. In the present study, we compared homocysteine levels in OSA patients to normal control subjects with similar characteristics.…”

Section: Introductionmentioning

confidence: 99%

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Plasma homocysteine in obstructive sleep apnoea

Svatikova

Wołk

Magera

et al. 2004

European Heart Journal

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Aims Whether increased homocysteine is one mechanism linking obstructive sleep apnoea (OSA) to cardiovascular abnormalities is unclear. We hypothesised that plasma homocysteine would be higher in OSA patients than in control subjects, would increase further during sleep, and decrease after treatment with continuous positive airway pressure (CPAP). Methods and ResultsFor study A, homocysteine was measured in 22 OSA patients and 20 controls first before sleep, then after 5 h of untreated OSA, and then in the morning after CPAP treatment. Homocysteine was similar in the OSA and control subjects at all three time points, and declined overnight in both groups (P ¼ 0:0017, P ¼ 0:036, respectively). To further assess this diurnal variation, we studied plasma homocysteine under a full-night protocol in 10 OSA patients and 12 controls (study B). Homocysteine was measured before sleep, in the morning after sleep, and at noon. Results in both OSA and control groups showed an overnight decline in homocysteine which was reversed by noon (repeated measures ANOVA: OSA, P ¼ 0:04; controls, P ¼ 0:02). Study C showed that disturbed sleep did not affect homocysteine levels in normal subjects. Conclusion There is a significant diurnal variation in plasma homocysteine, so that homocysteine is lower in the morning after waking. Neither OSA nor disturbed sleep elicit acute or chronic changes in homocysteine.

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Section: Discussionmentioning

confidence: 99%

“…24 Because of consistent data showing increased homocysteine in obese individuals, [20][21][22][23] we also calculated a homocysteine/BMI ratio in all subjects.…”

Section: Methodsmentioning

confidence: 99%

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Plasma homocysteine in obstructive sleep apnoea

Svatikova

Wołk

Magera

et al. 2004

European Heart Journal

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“…Oxidant stress may be a major modulator of disease progression when it is part of a cluster of inflammatory, prothrombotic and metabolic markers in android obesity. 27 Konukoglu et al 28 measured plasma concentrations of TBARS and copper in middle-aged nonobese and obese normotensive and hypertensive subjects (N ¼ 130). TBARS concentrations were highest in the obese hypertensives (8.4571.09 mmol/l) and lowest in the nonobese normotensives (5.5570.65 mmol/l).…”

Section: Obesity and Evidence Of Oxidant Stress In Humansmentioning

confidence: 99%

Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans

2005

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Objective: Oxidative stress may be the unifying mechanism underlying the development of comorbidities in obesity. Evidence suggests that a clustering of sources of oxidative stress exists in obesity: hyperglycemia, hyperleptinemia, increased tissue lipid levels, inadequate antioxidant defenses, increased rates of free radical formation, enzymatic sources within the endothelium, and chronic inflammation. Method: This review provides a summary of the available evidence on systemic oxidative stress in humans and specific metabolic pathways by which obesity may elevate systemic oxidant stress. The authors suggest possible methods of reducing oxidative stress such as antioxidant supplementation, caloric restriction and/or physical activity and surgical intervention to combat free radicals and reduce adipose tissue. Results: Obesity is associated with oxidative stress and can be reduced with weight loss (regardless of exercise or surgery induced weight loss), caloric restriction or antioxidant rich diets. Conclusion: Oxidative stress levels are elevated in human obesity, and these levels are modifiable with various lifestyle modifications and surgical interventions.

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“…Methionine is an amino acid, which leads to increased blood levels of homocysteine, which has an atherogenic effect (Gąsiorowska et al, 2008;Wichlińska-Lipka and Nyka, 2008). Konukoğlu et al (2003) point out that among obese people even normal levels of homocysteine can damage the endothelium, and lead to oxidative stress and, consequently, the development of atherosclerotic plaque. In our study, we found a positive correlation between the energy from protein and energy in the diet and body weight in the women and men.…”

Section: Discussionmentioning

confidence: 99%

Dietary gender differences in terms of the risk of atherogenesis in Poland

Śmidowicz

Reguła

2015

Acta Sci Pol Technol Aliment

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Introduction. Diet plays an important role in prevention of atherosclerosis. The objective of the study was to assess differences in the dietary intake and nutritional status in women and men in terms of atherogenesis risk. Material and methods. The study involved 41 women and 49 men aged 40+. The nutrient intake was assessed using 7-day dietary records. The nutritional status was estimated on the basis of antropometric measurements and biochemical blood parameters. The differences between diets and the nutritional status depending on sex was evaluated by oneway analysis of variance. The dependencies between the nutritional status and the diet factors were assessed using multiple regression. Results and discussion. It was found that a signifi cant proportion of the women and men were overweight or obese, had lipid disorders and impaired fasting glucose. Diets of women and men were poorly balanced. A signifi cant correlation between the level of energy from protein, as well as the energy supply and the LDL cholesterol concetration was found in the women. A positive correlation between energy from protein as well as total energy in the diet and body weight, was observed in women and men. Moreover, protein intake was positively correlated with BMI and waist circumference among the men. In the men, the level of serum triglycerides correlated with an increase in dietary cholesterol and a decrease in energy value. Conclusion. This study indicates that an inadequate diet among both men and women represents a real health danger of developing atherosclerotic plaque.

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Plasma homocysteine levels in obese and non-obese subjects with or without hypertension; its relationship with oxidative stress and copper

Cited by 63 publications

References 13 publications

Plasma homocysteine in obstructive sleep apnoea

Plasma homocysteine in obstructive sleep apnoea

Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans

Dietary gender differences in terms of the risk of atherogenesis in Poland

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