Plasma homocysteine levels associated with a corrected QT interval

Li, Zhao; Guo, Xiaofan; Sun, Guozhe; Zheng, Liqiang; Sun, Yingxian; Liu, Yamin; Abraham, M. Roselle

doi:10.1186/s12872-017-0617-z

Cited by 7 publications

(6 citation statements)

References 40 publications

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“…They found the mean homocysteine levels among participants who had QTc > 440 ms were higher than those who had QTc 440 ms (p ¼ .031). However, this study showed that the prolonged QT was related to both high and low homocysteine levels [73]. Hyperhomocysteinemia can affect the synchronization of myocardial contraction, reflected by the prolongation of the QRS and QT interval on electrocardiogram.…”

Section: Uremic Toxinsmentioning

confidence: 59%

Acquired long QT syndrome in chronic kidney disease patients

et al. 2019

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Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated with an increased risk of torsade de pointes (TdP), sudden cardiac death (SCD), and all-cause mortality in the general population. The prevalence of acquired long QT syndrome (aLQTS) is high, and various acquired conditions contribute to the prolonged QT interval in patients with CKD. More notably, the prolonged QT interval in CKD is an independent risk factor for SCD and all-cause mortality. In this review, we focus on the epidemiological characteristics, risk factors, underlying mechanisms and treatments of aLQTS in CKD, promoting the management of aLQTS in CKD patients.

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Section: Uremic Toxinsmentioning

confidence: 59%

Acquired long QT syndrome in chronic kidney disease patients

et al. 2019

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“…In the present study, we demonstrated that even HHcy alone increased the risk of LVH. Our research team previously reported that higher plasma homocysteine levels were associated with a long QTc interval [33]. A long QTc interval is relevant to ventricular arrhythmia, which might result in sudden cardiac death [34].…”

Section: Discussionmentioning

confidence: 99%

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

Chen

Yang

et al. 2020

BMC Cardiovasc Disord

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Background: To investigate the influence of hyperhomocysteinemia (HHcy) and metabolic syndrome (MetS) on left ventricular hypertrophy (LVH) in residents in rural Northeast China. Methods: We performed a cross-sectional baseline data analysis of 6837 subjects (mean age: 54 ± 10 years) recruited from a rural area of China. Anthropometric indicators were measured according to standard methods. MetS was defined by the modified ATP III criteria. HHcy was defined according to the WHO standard: an Hcy level > 15 μmol/L representing HHcy. Four groups were defined: non-HHcy & non-MetS, HHcy & non-MetS, MetS & non-HHcy and HHcy & MetS. Results: The left ventricular mass index for height 2.7 (LVMH 2.7) in both sexes was significantly higher in the HHcy & MetS group than in the non-HHcy & non-MetS group (females: 51.23 ± 16.34 vs. 40.09 ± 10.55 g-2.7 , P < 0.001; males: 48.67 ± 12.24 g-2.7 vs. 42.42 ± 11.38 g-2.7 , P < 0.001). A similar result was observed in those groups when using the left ventricular mass index (LVMI) for body surface area to define LVH (females: 103.58 ± 31.92 g − 2 vs. 86.63 ± 20.47 g − 2 , P < 0.001; males: 106.10 ± 24.69 g − 2 vs. 98.16 ± 23.29 g − 2 , P < 0.001). The results of multiple regression analysis indicated that the HHcy & MetS group had a higher risk of LVH than the other three groups (OR: 1.628 for LVMI, P < 0.001, OR: 2.433 for LVMH 2.7 , P < 0.001). Moreover, subjects in the HHcy & non-MetS group [OR (95% CI): 1.297 (1.058, 1.591) for LVMI, P < 0.05; OR (95% CI): 1.248 (1.044, 1.492) for LVMH 2.7 , P < 0.05] also had a statistically greater risk of LVH than subjects in the non-HHcy & non-MetS group. The HHcy & non-MetS group was also found to be significantly and independently associated with LVH. Conclusion: Hyperhomocysteinemia has an independent effect on LVH. The combined effect of MetS and hyperhomocysteinemia might increase the strength of the abovementioned effects.

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“…The data collection and measurements used in this study were described in previous studies [ 10 , 12 – 14 ]. Data were collected via a single visit by experienced cardiologists and trained nurses, where a standard questionnaire was used by a face-to-face interview.…”

Section: Methodsmentioning

confidence: 99%

Impact of hypertension with or without diabetes on left ventricular remodeling in rural Chinese population: a cross-sectional study

Chen

Guo

et al. 2017

BMC Cardiovasc Disord

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BackgroundThe aim of this study was to assess the impact of hypertension with or without diabetes on left ventricular (LV) remodeling in rural Chinese population.MethodsA total of 10,270 participants were classified into control group, hypertension without diabetes (HT) group, and hypertension with diabetes (HT + DM) group. We compared clinical characteristics and echocardiographic parameters, and used multivariable logistic regression analysis to assess the associations of interest.ResultsHT + DM group had higher interventricular septal thickness (IVSd), posterior wall thickness (PWTd), left ventricular mass (LVM), LVM index (LVMI), relative wall thickness (RWT), left atrial diameter (LAD), A wave and lower E wave than HT group (all P < 0.05). The prevalence rates of left ventricular hypertrophy (LVH) and abnormal geometry were statistically different among three groups (P < 0.001) and eccentric hypertrophy was the highest proportion of geometry abnormality. Logistic regression analysis suggested that subjects in HT and HT + DM groups had odds ratio (OR) values of 2.81, 4.41, 2.24 and 3.94, 7.20, 2.38 for LVH, concentric hypertrophy and eccentric hypertrophy in the total population, respectively, compared to control group. When compared with HT group, those in HT + DM group had approximately 1.40-, 1.61- and 1.38-, 1.71-fold increased risk for LVH and concentric hypertrophy in the total and female population separately, but no association of HT + DM with LVH and abnormal geometrical patterns was found in men.ConclusionsThis study demonstrated that, to varying degrees, hypertension was associated with LV remodeling in rural Chinese population, and this risk association was obviously increased for LVH and concentric hypertrophy when accompanied by diabetes, especially for women.

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Plasma homocysteine levels associated with a corrected QT interval

Cited by 7 publications

References 40 publications

Acquired long QT syndrome in chronic kidney disease patients

Acquired long QT syndrome in chronic kidney disease patients

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

Impact of hypertension with or without diabetes on left ventricular remodeling in rural Chinese population: a cross-sectional study

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