Abstract:BackgroundAlthough observational studies have demonstrated associations between elevated plasma homocysteine levels and the risk of cardiovascular diseases, controversy remains.ObjectiveThis study investigated the causal association of plasma homocysteine levels with congestive heart failure and cardiomyopathy risk.MethodsWe performed a two-sample Mendelian randomization (MR) study of congestive heart failure (n = 218,792), cardiomyopathy (n = 159,811), and non-ischemic cardiomyopathy (n = 187,152). Genetic su… Show more
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