Plasma homocysteine level and development of coronary artery disease

Kawashiri, Masa‐aki; Kajinami, Kouji; Nohara, Atsushi; Yagi, Kunimasa; Inazu, Akihiro; Koizumi, Junji; Haraki, Tatsuo; Takegoshi, Tadayoshi; Mabuchi, Hiroshi

doi:10.1097/00019501-199910000-00002

Cited by 18 publications

(12 citation statements)

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“…Methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, and plays a critical role in homocysteine to methionine methylation [1,2]. Reduced MTHFR levels or activity leads to hyperhomocysteinemia [1], seen in patients with vascular diseases [3], and is regarded as a risk factor for coronary artery disease (CAD) and deep-vein thrombosis (DVT) [3][4][5]. The C677T mutation is a point mutation in the MTHFR gene which substitutes alanine for valine and which is associated with a decreased enzyme activity due to thermolability [6], resulting in a relative deficiency in the homocysteine-to-methionine methylation and hence pathogenesis of atherosclerotic events [6].…”

Section: Introductionmentioning

confidence: 99%

“…For example, a high prevalence of the TT genotype was reported for Mexico (34.8%) [7], Italy (21.4%) [2], and France (16.8%), while lower prevalences were reported for Thailand (1.4%) and India (2.0%). Insofar as the MTHFR C677T mutation is among the most common inherited contributor to diseases including cardiovascular disorders [4,5], type 2 diabetes, recurrent abortions, among others, coupled with its selective distribution, the aim of this study was to determine prevalence of MTHFR C677T mutation among healthy Lebanese subjects.…”

Section: Introductionmentioning

confidence: 99%

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Differences in the frequency of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene among the Lebanese population

et al. 2004

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In view of its role in precipitating mild hyperhomocysteinemia as well as being a risk factor for vascular thrombosis, we investigated the frequency of the C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene among 589 healthy Lebanese subjects by PCR-RFLP analysis (HinfI digestion) and compared them with those of other countries of Caucasian and non-Caucasian origin. The prevalence of the mutated homozygous (T/T) and heterozygous (C/T) C677T MTHFR genotype was 11.04% and 39.73%, respectively, giving an allele frequency of 0.309. While the prevalence of the T/T genotype was similar with respect to gender, higher prevalence was noted among Christian (13.08%) compared to Moslem (7.66%) subjects (P < 0.001), and heterogeneity in its distribution was seen in the different Lebanese provinces, and was directly related to the Christian/Moslem composition of each province. The distribution of the MTHFR C677T in Lebanon is unique with regard to its higher occurrence among Christians compared to Moslems, adding to the existing body of literature on the heterogeneity of its prevalence and distribution.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Differences in the frequency of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene among the Lebanese population

et al. 2004

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“…Increased plasma total homocysteine is an established independent risk factor for the development of atherosclerotic vascular disease. Epidemiological studies have shown that even mild hyperhomocysteinaemia (HHcy) is associated with coronary artery disease (Kawashiri et al 1999;Abdelmouttaleb et al 2000), myocardial infarction (Al-Obaidi et al 2000;Christensen et al 2000;Senaratne et al 2000), peripheral arterial disease (Taylor et al 1999;Mansoor et al 2000), cerebrovascular disease (Zhang et al 1998;Moller et al 2000), stroke (Van Beynum et al 1999;Hankey & Eikelboom, 2001), cardiac allograft vasculopathy (Cooke et al 2000;Parisi et al 2000) and death from coronary artery disease. Plasma homocysteine (Hcy) concentration is a function of the complex interactions between genetic and environmental factors, such as vitamin status, hormonal factors, lifestyle and diet (Nygard et al 1998).…”

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confidence: 99%

Effect of a methionine-supplemented diet on the blood pressure of Wistar–Kyoto and spontaneously hypertensive rats

et al. 2003

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The objectives of the present work were to evaluate the effect of a methionine-supplemented diet as a model of hyperhomocysteinaemia on the systolic blood pressure (BP) and vasomotor functions of aortic rings in Wistar -Kyoto (WKY) and spontaneously hypertensive rats (SHR). WKY and SHR rats, randomised into four groups, were fed a normal semisynthetic diet or a methionine (8 g/kg)-supplemented diet for 10 weeks. Systolic BP was measured non-invasively. At the end of the experiment, plasma homocysteine, methionine, cysteine and glutathione levels were determined. Vasoconstriction and vasodilatation of aortic rings were measured. The methionine-supplemented diet induced a significant increase in plasma homocysteine and methionine concentration in both WKY and SHR rats, an increase in plasma cysteine concentrations in WKY rats and an increase in the glutathione concentration in SHR. The systolic BP of WKY rats fed the methionine-supplemented diet increased significantly (P,0·01), whereas systolic BP was reduced in SHR. An enhanced aortic responsiveness to noradrenaline and a decreased relaxation induced by acetylcholine and bradykinin were observed in the WKY rats fed the methionine-enriched diet. In SHR, the bradykinin-induced relaxation was reduced, but the sodium nitroprusside response was increased. In conclusion, a methionine-enriched diet induced a moderate hyperhomocysteinaemia and an elevated systolic BP in WKY rats that was consistent with the observed endothelial dysfunction. In SHR, discrepancies between the decreased systolic BP and the vascular alterations suggest more complex interactions of the methionine-enriched diet on the systolic BP. Further investigations are needed to understand the paradoxical effect of a methionine-rich diet on systolic BP.

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“…7 In our cross sectional study, we found mean serum homocysteine level was significantly higher in younger age group (15.1±8.2 mmol/L vs. 11.2±7.8 mmol/L, p=0.009). Kawashiri et al 14 reported that plasma homocysteine level of subjects in younger IHD group was significantly higher than that of subjects in older IHD group (15.0 vs11.3 nmol/ml, p=0.03). Sadeghian et al 15 concluded that hyperhomocysteinemia is an independent risk factor for CAD in young, especially in men.…”

Section: Discussionmentioning

confidence: 95%

Effect of Serum Homocysteine on Coronary Artery Disease in Younger and Older Ischaemic Heart Disease Patients

Islam

Chowdhury

Khondoker³

et al. 2016

Cardiovasc. j.

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Background: Hyperhomocysteinemia is known as an independent risk factor of atherosclerosis. But the probable role of Hyperhomocysteinemia in Premature Coronary Artery Disease (CAD) is not well studied. The aim of this study was to assess the role of serum homocysteine on angiographically documented CAD in younger and older ischaemic heart disease (IHD) patients.Methods: Total 120 patients with IHD admitted in the Department of Cardiology, Dhaka Medical College Hospital for CAG were selected by purposive sampling method and divided into two groups. 60 patients in Group-I, d 40 years of age (Younger); 60 patients in Group-II, >40 years of age (Older). Homocysteine was measured in all patients and other demographical and clinical data were collected. Homocysteine level was correlated with the presence and severity of CAD.Results: Smoking, positive family history of IHD, dyslipidaemia and hyper homocysteinemia were important risk factors in younger IHD patients. Whereas, hypertension, diabetes mellitus and dyslipidaemia were important cardiovascular risk factors in older age group. Obesity was not an important risk factors as evidenced by mean BMI. Serum homocysteine was not well related to presence of CAD or extent of CAD in older IHD patients. However in younger patients hyperhomocysteinemia was related to both presence and severity of CAD.Conclusion: In younger IHD patients hyperhomocysteinemia is an important cardiovascular risk factor. But in older patients it loses its significance. So serum homocysteine level should be screened routinely in younger IHD patients.Cardiovasc. j. 2016; 8(2): 138-142

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Plasma homocysteine level and development of coronary artery disease

Cited by 18 publications

References 0 publications

Differences in the frequency of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene among the Lebanese population

Differences in the frequency of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene among the Lebanese population

Effect of a methionine-supplemented diet on the blood pressure of Wistar–Kyoto and spontaneously hypertensive rats

Effect of Serum Homocysteine on Coronary Artery Disease in Younger and Older Ischaemic Heart Disease Patients

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