Plasma homocysteine in schizophrenia: Determinants and clinical correlations in Tunisian patients free from antipsychotics

Bouaziz, Noomen; Ayedi, Imen; Sidhom, Oussama; Kallel, Ameni; Rafrafi, R.; Jomaa, Riadh; Melki, W.; Feki, Moncef; Kaabechi, Naziha; Hechmi, Z. El

doi:10.1016/j.psychres.2010.04.008

Cited by 44 publications

(23 citation statements)

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“…These results are in line with previous studies showing that higher Hcy and lower folate levels are associated with higher severity of negative symptoms (Goff et al 2004; Petronijevic et al 2008; Bouaziz et al 2010). However, there are also studies, which have failed to confirm this relationship (Neeman et al 2005; Ma et al 2009; Ayesa-Arriola et al 2012).…”

Section: Discussionsupporting

confidence: 93%

“…These include sample size, the lack of quantitative assessment of cannabis use and evaluation of dietary intake, possible under-reporting bias of cannabis use within 1 year prior to the onset of psychosis and the influence of antipsychotic treatment. Although our sample was not large, it corresponds with sample sizes of previous studies on one-carbon metabolism deregulation in drug-naïve and/or FES patients (Bicikova et al 2011; Kale et al 2010; Bouaziz et al 2010). Rates of under-reported illicit drug use in schizophrenia patients are considerable.…”

Section: Discussionmentioning

confidence: 73%

“…It has also been found that a 5-μmol/l increase of plasma Hcy may increase the risk of schizophrenia by 70 % (Muntjewerff et al 2006). Additionally, Hcy level may positively correlate with duration of untreated psychosis (DUP) (Ayesa-Arriola et al 2012), the severity of negative symptoms (Goff et al 2004; Petronijevic et al 2008; Bouaziz et al 2010) and cognitive deficits (Levine et al 2006). Some authors suggest that mainly young schizophrenia males demonstrate elevated Hcy levels (Levine et al 2002).…”

Section: Introductionmentioning

confidence: 99%

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Elevated homocysteine level in first-episode schizophrenia patients—the relevance of family history of schizophrenia and lifetime diagnosis of cannabis abuse

et al. 2014

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Accumulating evidence indicates that elevated homocysteine (Hcy) level occurs in first-episode schizophrenia (FES) patients. We included 56 FES patients and 53 healthy controls (HC). Plasma level of Hcy was significantly higher in FES patients than HC (p = 0.044). In addition, plasma levels of high-density lipoproteins (HDL) and folate were significantly lower in FES than in HC (p < 0.001). Positive family history of schizophrenia was associated with lower plasma HDL (p = 0.041) and vitamin B12 (p = 0.017), as well as higher level of Hcy (p = 0.017). Patients with FES, who abused cannabis, had higher levels of Hcy (p = 0.017), as well as lower levels of vitamin B12 (p = 0.017) and HDL (p = 0.041). Plasma Hcy negatively correlated with duration of untreated psychosis (r = −0.272, p = 0.042). There was a positive correlation between Hcy level and the severity of negative symptoms (r = 0.363, p = 0.006) and general psychopathology (r = 0.349, p = 0.008) assessed using Positive and Negative Syndrome Scale (PANSS). Vitamin B12 level was negatively associated with the severity of negative symptoms (r = −0.406, p = 0.002), while folate level negatively correlated with general psychopathology score (r = −0.365, p = 0.006) in PANSS. These results indicate that the severity of one-carbon metabolism alterations and HDL deficiency might be associated with family history of schizophrenia and cannabis abuse. Lower vitamin B12 and folate along with elevated Hcy may influence the severity of FES psychopathology.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

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Elevated homocysteine level in first-episode schizophrenia patients—the relevance of family history of schizophrenia and lifetime diagnosis of cannabis abuse

et al. 2014

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“…Several studies have provided evidence that Hcy levels are positively correlated with the severity of negative symptoms [42, 4, 39, 43, 44]. Additionally, it has been demonstrated that polymorphisms in the MTHFR gene are associated with negative symptoms severity [45, 46].…”

Section: Discussionmentioning

confidence: 99%

Effects of second-generation antipsychotics on selected markers of one-carbon metabolism and metabolic syndrome components in first-episode schizophrenia patients

Misiak

Frydecka

Łaczmański

et al. 2014

Eur J Clin Pharmacol

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PurposeAlterations in one-carbon metabolism (OCM) have been repeatedly reported in schizophrenia. However, there is a scarcity of studies addressing the effects of antipsychotics on selected OCM markers in schizophrenia and provided results are inconsistent.MethodsWe recruited 39 first-episode schizophrenia (FES) patients and determined serum profile of total homocysteine (tHcy), folate, vitamin B12, lipoproteins and glucose at baseline and after 12 weeks of treatment with second-generation antipsychotics (SGA) including olanzapine and risperidone in monotherapy.ResultsAfter 12 weeks of treatment, all patients had significantly higher body mass index (BMI), serum levels of total cholesterol (TC), low-density lipoproteins (LDL), triglycerides (TG) and tHcy together with significantly lower levels of folate and vitamin B12. The analysis of differences between SGA revealed the same biochemical alterations in patients treated with olanzapine as in the whole group, while those receiving risperidone had no statistically significant changes in serum folate, vitamin B12 and TG. There was a significantly higher increase in BMI and TC in patients treated with olanzapine in comparison with those treated with risperidone. Patients receiving olanzapine had a higher decrease in vitamin B12 than those assigned to the treatment with risperidone. Changes in folate, vitamin B12, tHcy and TC levels were significant only in males, even after Bonferroni correction. Multiple regression analysis revealed that changes in tHcy levels are associated with gender and baseline metabolic parameters (BMI, glucose, TC, LDL and HDL) but not with selected SGA.ConclusionsThese results indicate that SGA may influence OCM, especially in first-episode schizophrenia (FES) males.Electronic supplementary materialThe online version of this article (doi:10.1007/s00228-014-1762-2) contains supplementary material, which is available to authorized users.

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“…An increased level of homocysteine has been observed in various psychiatric disorders including schizophrenia [1], depression [2] and bipolar mood disorder [3]. Israeli researchers demonstrated elevated homocysteine levels in euthymic male bipolar patients, and in these subjects, higher homocysteine level was related to poorer performance on a task of executive function [4].…”

Section: Introductionmentioning

confidence: 99%

Are Genes Connected with Homocysteine Metabolism Associated with Bipolar Disorder?

Permoda-Osip¹,

Dmitrzak‐Węglarz

Hauser

et al. 2014

Neuropsychobiology

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Background: Increased levels of homocysteine have been observed in various psychiatric disorders, among them in schizophrenia, depression and bipolar mood disorder. Of the genes connected with homocysteine metabolism, some studies have found an association between polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene and bipolar disorder. The aim of this study was to investigate a possible association between 5 polymorphisms of 4 genes coding enzymes of homocysteine metabolism and bipolar disorder. Method: A total of 120 patients with bipolar disorder (24 male, 96 female) and 167 subjects from the general population (81 male, 86 female) were included in the study. Genotyping was performed for the C677T (rs1801133) and A1298C (rs1801131) polymorphisms of the MTHFR gene, for the T833C polymorphism (rs5742905) of the cystathionine-β-synthase (CBS) gene, for the A2756G polymorphism (rs1805087) of the homocysteine methyltransferase gene, and for the A66G polymorphism (rs1801394) of the methionine synthase reductase (MTRR) gene. Results: An association with bipolar disorder was found for the T833C polymorphism (rs5742905) of the CBS gene. However, in the patient sample, the genotypes of this polymorphism were not in Hardy-Weinberg equilibrium. No relationship to bipolar disorder was obtained for the remaining polymorphisms studied. Conclusions: These results are the first suggesting a possible association between T833C polymorphism (rs5742905) of the CBS gene and bipolar disorder. We were unable to confirm an association between bipolar disorder and C677T polymorphism (rs1801133) of the MTHFR gene, as suggested in some previous studies.

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Plasma homocysteine in schizophrenia: Determinants and clinical correlations in Tunisian patients free from antipsychotics

Cited by 44 publications

References 41 publications

Elevated homocysteine level in first-episode schizophrenia patients—the relevance of family history of schizophrenia and lifetime diagnosis of cannabis abuse

Elevated homocysteine level in first-episode schizophrenia patients—the relevance of family history of schizophrenia and lifetime diagnosis of cannabis abuse

Effects of second-generation antipsychotics on selected markers of one-carbon metabolism and metabolic syndrome components in first-episode schizophrenia patients

Are Genes Connected with Homocysteine Metabolism Associated with Bipolar Disorder?

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