Plasma Homocysteine Distribution and Its Association With Parental History of Coronary Artery Disease in Black and White Children

Greenlund, Kurt J.; Srinivasan, Sathanur R.; Xu, Jihua; Dalferes, Edward R.; Myers, Leann; Pickoff, Arthur; Berenson, Gerald S.

doi:10.1161/01.cir.99.16.2144

Cited by 77 publications

(47 citation statements)

References 46 publications

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“…In our investigation as well as in studies from Spain (n ϭ 195, 2 mo to 18 y) (14), the US (n ϭ 1137, 5-17 y) (22) and the Netherlands (n ϭ 234, 0 -19 y) (17) including children and adolescents with a wide age distribution, gender differences for tHcy were not assessable. In contrast, in two large samples (n ϭ 1402 and n ϭ 3524 respectively) of adolescents (12-15 y, 16 -19 y (20) and 13-14 y (12)), tHcy was higher in males compared with females.…”

Section: Discussionmentioning

confidence: 68%

Total Homocysteine, Folate, and Cobalamin, and Their Relation to Genetic Polymorphisms, Lifestyle and Body Mass Index in Healthy Children and Adolescents

et al. 2006

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ABSTRACT:We investigated total homocysteine (tHcy) concentrations and relations between tHcy and folate, cobalamin (Cbl), genetic polymorphisms (MTHFR 677CϾT, MTHFR 1298AϾC, MTHFR 1793GϾA), blood pressure (BP), body mass index (BMI), cholesterol, triglycerides, sports activities, family and individual history of cardiovascular disease (CVD) and lifestyle issues in 264 healthy children and adolescents (2-17 y). THcy concentrations significantly increased while folate and Cbl decreased with age without gender differences. Age, folate and Cbl were significant predictors for tHcy concentrations. THcy was higher but within normal ranges in MTHFR 677TT homozygotes (10.6%) and carriers of the MTHFR 1793A allele (8%). Only two individuals (0.8%), both with low tHcy concentrations, were homozygous for MTHFR 1793AA. THcy concentration correlated positively with creatinine, triglycerides, BMI and systolic BP and was not related to cholesterol, sports activities and family history of CVD.In conclusion, tHcy concentrations in this pediatric population were significantly influenced by age, folate and Cbl concentrations. No gender differences for tHcy, folate or Cbl concentrations were observed. Both the MTHFR 677TT genotype and the MTHFR 1793A allele were not associated with hyperhomocysteinemia. The prevalence of the MTHFR 1793AA genotype was too low for meaningful interpretation. (Pediatr Res 60: 764-769, 2006)

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Section: Discussionmentioning

confidence: 68%

Total Homocysteine, Folate, and Cobalamin, and Their Relation to Genetic Polymorphisms, Lifestyle and Body Mass Index in Healthy Children and Adolescents

et al. 2006

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“…Secondary analysis of existing datasets is possible when scientific rigor is maintained such that the operational variables, including reliability and validity of measures, are congruent and samples are comparable across datasets. 43 The purpose of this study was to compare the dietary energy (kilocalories), the intake of macronutrients and micronutrients of folate, and vitamins B 6 and B 12 , as well as the serum lipid profiles and tHcy levels for adolescents with type 1 DM, type 2 DM, and healthy non-DM controls. Sodium intake among the 3 groups was also evaluated.…”

Section: Introductionmentioning

confidence: 99%

Total Homocysteine, Diet, and Lipid Profiles in Type 1 and Type 2 Diabetic and Nondiabetic Adolescents

Faulkner¹,

Chao²,

Kamath³

et al. 2006

The Journal of Cardiovascular Nursing

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Background and Research Objective-Limited research is available on the possible differences in the cardiovascular risk factors of total homocysteine (tHcy), dietary energy, and lipids among adolescents with type 1 diabetes mellitus (DM), type 2 DM, or healthy controls. This study's primary aim was to compare the dietary energy and the intake of macronutrients and micronutrients of folate, and vitamins B 6 and B 12 , as well as lipids and tHcy for adolescents with type 1 DM, type 2 DM, and healthy non-DM controls.

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“…presentaban incrementos con la edad; estos niveles de homocisteína fueron semejantes a los encontrados en niños noruegos, belgas y norteamericanos, donde además reportan igual correlación positiva con edad y sexo (9)(10)(11)29,30).…”

Section: Discussionunclassified

“…Los municipios fueron seleccionados de forma aleatoria, los que no aceptaron participar en el estudio fueron sustituidos por otros municipios; de igual manera se procedió con los colegios que habían sido seleccionados a partir de la información suministrada por las secretarías de educación. Se tomaron muestras de sangre en tubos con EDTA (ácido etilendiaminotetraacético tripotásico) después de un ayuno de 12 horas, y en el plasma obtenido, se analizaron los niveles de colesterol total y triglicéridos por un método colorimétrico enzimático (25)(26)(27), el colesterol de alta densidad (c-HDL) por precipitación de los quilomicrones y de las VLDL (lipoproteínas de muy baja densidad); el valor de c-LDL se obtuvo con la ecuación de Friedewald; la homocisteína por inmunoensayo enzimático competitivo (EIA) y fluorescencia utilizando el equipo IM X de Abbott (28), con un rango de referencia de 5,0 a 15,0 µmol/L en adultos; para población infantil se tuvieron en cuenta los rangos entre 4,9 y 6,3 µmol/L y mayor a 6,3 µmol/ L, valores obtenidos en estudios realizados en niños (9)(10)(11)29,30); la proteína C reactiva se midió en un equipo Selectra por un método ultrasensible turbidimétrico (Randox); el rango del ensayo era de 0 mg/L a 160 mg/L; los valores de 0-5 mg/L (0,5 mg/dl) se consideran normales en población adulta (31,32).…”

Section: Materiales Y Métodosunclassified

Marcadores de riesgo cardiovascular en escolares de cinco departamentos de la región oriental en Colombia

et al. 2008

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Introducción. La enfermedad cardiovascular es un problema de salud pública en el mundo y representa la segunda causa de mortalidad en Colombia; de ahí, la importancia de identificar marcadores de riesgo desde la infancia, para disminuir las tasas de mortalidad. Objetivos. Determinar el perfil lipídico, la homocisteína y la proteína C reactiva e identificar la relación entre estos marcadores con edad, sexo y tipo de colegio, en escolares entre 5 y 14 años. Materiales y métodos. Estudio descriptivo de 600 escolares, en el que se evaluaron lípidos, homocísteina y proteína C reactiva en plasma. Resultados. Los promedios de colesterol total, colesterol de baja densidad y triglicéridos fueron más elevados en las niñas que en los niños (p<0,05); la prevalencia de lípidos elevados fue mayor en las niñas que en los niños: 7,9% Vs. 3,0%; 11,6% Vs. 4,7% y 6,9% Vs. 5,7% para colesterol total, colesterol de baja densidad y triglicéridos, respectivamente. Con relación a los colegios, los privados mostraron niveles de lípidos más altos que los públicos (p<0,05). La prevalencia de niveles de homocisteína mayores de 6,3 µmol /L fue más alta en los varones (64,3%) que en las niñas (56,1%); las concentraciones de proteína C reactiva no presentaron diferencias estadísticamente significativas por sexo, edad o tipo de colegio. Conclusiones. La prevalencia de niveles altos de perfil lipídico observados en las niñas, sugieren la posibilidad de implementar medidas de intervención en la población infantil. Es necesario investigar la intervención de otros factores, en los niveles de homocisteína de los varones y en la proteína C reactiva, para determinar su contribución en las enfermedades cardiovasculares.Palabras clave: enfermedades cardiovasculares/epidemiología, colesterol, triglicéridos, homocisteína, proteína C-reactiva, niño. Cardiovascular risk markers in schoolchildren from five provinces of eastern ColombiaIntroduction. Cardiovascular disease is a public health problem globally; it represents the second cause of mortality in Colombia. This highlights the importance of identifying risk markers from the time of childhood, in order to diminish mortality rates proactively. Objectives. The lipid profile, homocysteine and C reactive protein plasma concentrations were determined in order to identify relationships between these markers and age, sex and school type. Materials and methods. A descriptive study was undertaken in 600 schoolchildren, aged 5 to 14, where the lipid profile, and the plasmatic concentrations of homocysteine and Creactive protein were evaluated. Results. Higher average levels of total cholesterol, low density cholesterol and triglycerides were observed in females (p<0.05) as compared with males. The prevalences of high lipid were higher in females than in males-7.9% vs. 3.0% for total cholesterol; 11.6% vs. 4.7% for low density cholesterol and 6.9% vs. 5.7% for triglycerides. Children in private schools had higher levels of lipid than those in public ones (p<0.05). The prevalence of homocysteine levels above 6.3 µ...

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Plasma Homocysteine Distribution and Its Association With Parental History of Coronary Artery Disease in Black and White Children

Abstract: Higher homocysteine levels were observed among children with a positive family history of CAD. Additional studies should elucidate the contribution of genetic, dietary, and other factors to homocysteine levels in children.

Cited by 77 publications

References 46 publications

Total Homocysteine, Folate, and Cobalamin, and Their Relation to Genetic Polymorphisms, Lifestyle and Body Mass Index in Healthy Children and Adolescents

Total Homocysteine, Folate, and Cobalamin, and Their Relation to Genetic Polymorphisms, Lifestyle and Body Mass Index in Healthy Children and Adolescents

Total Homocysteine, Diet, and Lipid Profiles in Type 1 and Type 2 Diabetic and Nondiabetic Adolescents

Marcadores de riesgo cardiovascular en escolares de cinco departamentos de la región oriental en Colombia

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