Plasma Homocysteine Concentrations In Patients With Rheumatoid Arthritis

Vasiljevic, Dragan; Lucic, Aleksandra Tomic; Živanović, Sandra; Milosavljević, Mirjana; Radovanovic, Snezana; Andjelkovic, Nebojsa; Djuric, Dragan; Veselinović, Mirjana

doi:10.1515/sjecr-2015-0027

Cited by 6 publications

(16 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The correlation between disease-related clinical characteristics among RA patients is demonstrated in Table 7. Hcys levels was strongly and significantly correlated with DAS28-CRP, CRP and ACCP Table (7 Similarly, same findings were detected by other studies (Vasiljevic et al,.2015, andAbd El-Aziz TA andMohamed RH. 2017).…”

Section: Correlation Between Disease-related Characteristics Among Ra...supporting

confidence: 78%

Homocysteine Level Status in Patients with Rheumatoid Arthritis in Duhok: in Relation to Disease. Activity Score

Younis

2022

UOD

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) causes high rate of the mortality. Cardiovascular disease (CVD) is markedly elevated in RA partly due to accelerated atherosclerosis (AS) from chronic inflammation. Homocysteine’ elevation (Hcys) strongly related to the AS and CVD’s progression in RA. Current study aims to evaluates Hcys level status and its relation with disease activity (DA) and inflammation marker (CRP) in Duhok RA patients. Sixty-four RA patients (case) were involved in this study with equal number of healthy individuals (control), means± SD of their age were 47.78 ± 14.08 and 46.98 ± 15 respectively. ratio of females to males was (8.1 and 7.0) in case and control respectively. Blood was analyzed and RA related laboratory and biochemical markers were investigated. The results revealed that Means±SD of Hcys was higher in case comparing to control (17.30±8.52 and 7.2±3.4) respectively. RA patient with high DA score recorded higher percentage intra group of increased Hcys level (52%). This study concludes that there is a strong association between Hcys level and RA activity, severity and inflammation process in RA Duhok patients. Hcys could play role as a predictor marker helping physicians for good monitoring and managing RA disease

show abstract

Section: Correlation Between Disease-related Characteristics Among Ra...supporting

confidence: 78%

Homocysteine Level Status in Patients with Rheumatoid Arthritis in Duhok: in Relation to Disease. Activity Score

Younis

2022

UOD

View full text Add to dashboard Cite

show abstract

“…Few studies, with equivocal results, examined homocysteine levels in rheumatoid arthritis patients [ 7 , 22 – 24 ]. Data have shown substantial elevation in homocysteine with rheumatoid arthritis due to abnormal homocysteine metabolism [ 7 , 22 , 24 ]. One study have found that homocysteine was 33% greater than healthy counterparts [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Data have shown substantial elevation in homocysteine with rheumatoid arthritis due to abnormal homocysteine metabolism [ 7 , 22 , 24 ]. One study have found that homocysteine was 33% greater than healthy counterparts [ 22 ]. These abnormalities were attributed to low vitamin B 6 levels [ 7 ] and alteration in either the transsulfuration pathway or the regulation of the homocysteine cycle [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…These changes have been attributed to accelerated oxidative stress [ 43 ], inflammation [ 44 ], and reduced nitric oxide bioavailability [ 42 ], which can promote vascular inflammation and thrombogenesis [ 42 ]. In fact, a recent study found that elevated homocysteine in rheumatoid arthritis was related to inflammatory factors [ 22 ]. Furthermore, homocysteine increases blood clotting rate by changing the coagulation factor levels, thereby increasing small artery rigidity and vulnerability for plaque and clot formations [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Possible Modulation of Vascular Function Measures in Rheumatoid Arthritis by Homocysteine

Alomari

Khabour

Alawneh

et al. 2018

International Journal of Rheumatology

View full text Add to dashboard Cite

The effect of homocysteine on cardiovascular diseases is still equivocal, especially in rheumatoid arthritis patients. In this investigation, the association between homocysteine with blood flow and vascular resistance in rheumatoid arthritis was examined. Serum levels of homocysteine were determined in thirty-one rheumatoid arthritis patients and nineteen apparently healthy subjects using ELISA. Additionally, strain-gauge plethysmography was used to determine both forearm blood flow and vascular function at rest and after occlusion. Forearm occlusion blood flow (patients: 21.9 ± 6.55 versus control: 25.5 ± 6.10ml/100mL/min) was lower (p < 0.05) while occlusion vascular resistance (patients: 4.77 ± 2.08 versus controls 3.05 ± 0.96U) was greater (p < 0.01) in rheumatoid arthritis than in the controls. Level of serum homocysteine was similar (p = 0.803) in rheumatoid arthritis group and healthy group. In addition, level of serum homocysteine was correlated with resting blood flow (r = −0.41; p < 0.02) and resting vascular resistance (r = 0.31, p < 0.05) in the patients group. The study confirms altered vascular function in rheumatoid arthritis. Uniquely, the results show that homocysteine was related to resting, but not postischemia, vascular measures. These relationships indicate that homocysteine might impact the vasculature in rheumatoid arthritis.

show abstract

“…Increased serum HCY levels in patients with RA, in comparison to the general population, have been re ported by many authors [42][43][44].…”

Section: Homocysteine In Rheumatoid Arthritismentioning

confidence: 99%

The importance of homocysteine in the development of cardiovascular complications in patients with rheumatoid arthritis

et al. 2020

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) not only leads to disability due to joint changes, but also significantly shortens the life expectancy of patients, mainly due to more frequent occurrence of heart attacks and strokes. Accelerated atherosclerosis in these patients is caused, among other factors, by high homocysteine (HCY) concentration in blood. Numerous studies have shown that treatment with vitamin B significantly reduces the concentration of HCY in blood, but does not reduce the risk of heart diseases. Recent studies have shown, however, that folic acid (FA) administration reduces the risk of stroke by 10–20%. Due to the fact that in patients with RA strokes are more frequent than in the general population and hyperhomocysteinemia (HHCY) is often found, determination of HCY concentration in blood is advisable, and in persons with HHCY it is recommended to use FA in primary and secondary stroke prevention.

show abstract

Plasma Homocysteine Concentrations In Patients With Rheumatoid Arthritis

Cited by 6 publications

References 21 publications

Homocysteine Level Status in Patients with Rheumatoid Arthritis in Duhok: in Relation to Disease. Activity Score

Homocysteine Level Status in Patients with Rheumatoid Arthritis in Duhok: in Relation to Disease. Activity Score

Possible Modulation of Vascular Function Measures in Rheumatoid Arthritis by Homocysteine

The importance of homocysteine in the development of cardiovascular complications in patients with rheumatoid arthritis

Contact Info

Product

Resources

About