Plasma homocysteine and its relationships with atherothrombotic markers in psoriatic patients

Kural, Birgül Vanizör; Örem, Asım; Çimşit, Gülseren; Uydu, Hüseyin Avni; Yandı, Yunus Emre; Alver, Ahmet

doi:10.1016/s0009-8981(03)00082-2

Cited by 118 publications

(94 citation statements)

References 37 publications

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“…However, unlike these results, patients with psoriasis were found to have high blood homocysteine in other five studies again in our country and five in Italy and one each in Ireland and Norway [20][21][22][23][24][25][26][27][28][29][30][31] . In the literature, studies showing psoriasis being accompanied by high blood homocysteine seem to be predominant (Table 3).…”

contrasting

confidence: 75%

“…After the studies made in 1990s where high levels of homocysteine were found in plasma samples of subjects who had or would likely to have a history of myocardial infarction, ischemic stroke or peripheral vascular disease and the association of homocysteine with atherosclerosis and hypercoagulability had been shown [6][7][8][9][10][11][12] , along with increased attention to the comorbidities of psoriasis, as far as we know, 19 studies have been conducted to explore homocysteine levels in these patients. Homocysteine level was found to be high in 12 and normal in 7 of these studies [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] . Since this sulfur-containing amino acid is not taken through diet and not producing protein, homocysteine is formed via methionine catabolism 8,11,27 .…”

Section: Introductionmentioning

confidence: 99%

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Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Uslu¹,

Şendur²,

Şavk³

et al. 2017

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ÖzBackground and Design: Homocysteine, a sulfur-containing amino acid, is known to be related with autoimmunity-inflammation, cardiovascular disease and DNA methylation. In this case-control study, we aimed to determine plasma homocysteine, folic acid, vitamin B12 and vitamin B6 levels in patients with psoriasis. Materials and Methods: Smoking, alcohol and coffee consumption habits were recorded in adult patients with plaque-type psoriasis and age-and sex-matched controls. Height and weight measurements were performed and Psoriasis Area and Severity Index (PASI) scores were calculated. Fasting venous blood samples were collected to determine homocysteine, folic acid, vitamin B12, vitamin B6, glucose, total cholesterol, triglyceride, high density lipoprotein (HDL), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels. Results: There was no significant difference between psoriasis patients (n=43) and controls (n=47) in body mass index and alcohol and coffee consumption. Smoking rate was significantly high in psoriasis patients. The median PASI score was 10.0 (8.3-12.8). Plasma homocysteine, folic acid, vitamin B12, vitamin B6, total cholesterol, triglyseride, ESR and CRP values were not significantly different between patients and the controls. HDL level was low in psoriasis patients (p=0.001). Plasma homocysteine level was higher in males than in females. There was no relationship of homocysteine levels with patient's age, PASI scores, ESR, CRP values and lipids. Homocysteine levels were inversely related with folic acid and vitamin B12 (p=0.000, r=-0.436, p=0.047, r=-0.204, respectively). We did not find any relationship between homocysteine and vitamin B6 levels. Conclusion: There was no increase in plasma homocysteine levels in psoriasis patients we followed up. Homocysteine level increases in inflammatory disorders and this increase is accepted as a cardiovascular disease marker. Homocysteine homeostasis may be balanced in our patients because of the genetic background and/or nutritional habits in this population Keywords: Psoriasis, homocysteine, folic acid Amaç: Homosistein kardiyovasküler hastalık, otoimmünite-enflamasyon ve DNA metilasyonu ile ilişkilendirilen sülfür içeren bir aminoasittir. Bu olgu-kontrol çalışmasında psoriazisli hastalarda plazma homosistein düzeylerinin ve homosisteini etkileyen folik asit, vitamin B6 ve vitamin B12 düzeylerinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Polikliniğimizde takip edilen erişkin plak tip psoriazis hastaları ile yaş ve cinsiyet uyumlu kontrol grubunda alkol, kahve ve sigara tüketimi sorgulandı, katılımcıların boy ve ağırlıkları ölçüldü. Hastaların Psoriazis Alan Şiddet İndeksleri (PAŞİ) hesaplandı. Sabah açlık kan örnekleri alınarak homosistein, folik asit, vitamin B12, vitamin B6, kan şekeri, serum total kolesterol, trigliserid, yüksek yoğunluklu lipoproteinler (HDL), eritrosit sedimantasyon hızı (ESH) ve C-reaktif protein (CRP) değerleri çalışıldı. Bulgular: Psoriazisli hasta (n=43) ve kontrol grubu (n=47) arasında vücut kitle inde...

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contrasting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Uslu¹,

Şendur²,

Şavk³

et al. 2017

TURKDERM

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“…In a case controlled study we showed that psoriatic patients have a relative risk 7.1 times greater than controls of having significantly raised levels of homocysteine (Tobin et al, 2011). This was also found in 2 uncontrolled studies and one in the context of patients who are taking methotrexate (Vanizor Kural et al, 2003). Refsum and colleagues investigated the effect of low-dose methotrexate on plasma homocysteine in patients who had psoriasis.…”

Section: Homocysteinementioning

confidence: 72%

“…This may be mediated by adverse effects of fibrinogen on plasma viscosity, coagulation, platelet activity, inflammation and atherogenesis (Dziedzic, 2008;Kakfika et al, 2007). It is also known to be elevated in psoriasis and psoriatic arthritis (Marongiu et al, www.intechopen.com Recent Advances in Cardiovascular Risk Factors 74 1994;Rocha -Pereira et al, 2004;Vanizor Kural et al, 2003). This would indicate chronic inflammation and a possible role in increasing cardiovascular risk.…”

Section: Inflammationmentioning

confidence: 99%

“…Chronic inflammation causes endothelial dysfunction which leads to formation of atherosclerotic plaques in association with raised plasma lipids. Increased levels of oxidized low density lipoprotein in psoriatic plaques have been reported compared to controls (Rocha -Pereira et al, 2004;Vanizor Kural et al, 2003). Oxidized low-density lipoprotein is thought to promote atherosclerosis through complex inflammatory and immunologic mechanisms that lead to lipid dysregulation and foam cell formation.…”

Section: Endothelial Dysfunctionmentioning

confidence: 99%

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