Plasma histamine levels in polytraumatized patients

Abstract

In a prospective clinical trial, plasma histamine levels were measured in 28 polytrauma patients on day 1, 5 and 14 after trauma. Only those subjects who died were drop-outs. All patients had severe polytrauma with at least 3 body regions involved. The median plasma histamine levels at all three time points were significantly higher than in patients with single trauma of the extremities or before selective orthopaedic surgery but still in the normal range (less than 1 ng/ml). However, all patients with plasma levels above 1 ng/ml on days 1 and 5 died, as did all patients with levels above 0.5 ng/ml on day 1. Thus the elevation of plasma histamine levels, for whatever reason, appears to be a prognostic factor for bad outcome in polytrauma patients.

Interleukin-16 Expression in the Peripheral Blood and CD8 T Lymphocytes After Traumatic Injury

“…35 Findings show that CD8-positive cells can release chemotactic IL-16 in response to non-TCR-mediated stimuli such as histamine and serotonin, 36,37 which can be present after traumatic tissue injury. 38,39 The current data suggest that IL-16 release from CD8-positive T lymphocytes is included in those innate immune mechanisms that predominate in the immediate posttraumatic response.…”

Prediction of outcome in polytrauma canine patients

“…The most common features associated with poor outcome were head trauma, cranium fractures, or evidence of multiorgan failure, including ARDS, DIC, and cardiopulmonary arrest. Several different blood biochemical variables were identified as prognostic indicators in dogs following trauma such as ionized calcium concentrations (Holowaychuk and Monteith, 2011), plasma histamine levels (Ennis et al, 1990), and plasma beta-D-glucuronidase lysosomal enzyme activity (Chow et al, 2004). The purpose of our study was to determine which of the most easily and routinely measurable clinical and laboratory parameters had a prognostic value with regard to the outcome in polytraumatized dogs.…”

Detection of histamine-induced capillary protein leakage and hypovolaemia by determination of indocyanine green and glucose dilution method in dogs

“…After these measurements, both glucose 100 mg/kg (0.5 ml/kg) and ICG 0.5 mg/kg (0.2 ml/kg) (Daiichi Pharmaco Co. Ltd., Tokyo, Japan) were infused simultaneously through the central venous line over 30 s. Three millilitres of arterial blood was drawn for determining plasma glucose and ICG concentrations immediately before, and at 1,2,3,4,5,7,9,11,15,20 and 30 min after the glucose and ICG infusions. Prior to the first glucose and ICG administration, mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP), mean pulmonary artery pressure (MPAP), pulmonary capillary wedge pressure (PCWP) and urine volume (UV) were recorded.…”