Plasma HGF concentration in patients with brain tumorsRunning headline: HGF in patients with brain tumors

Siedlecki, Zygmunt; Grzyb, Sebastian; Rość, Danuta; Śniegocki, Maciej

doi:10.3934/neuroscience.2020008

Cited by 2 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is also involved in the branching tubular morphogenesis of epithelial cells and ECs and induces angiogenesis [135]. HGF exhibits strong mitogenic properties that regulate the development and regeneration of tissues [136]. In vivo experiments by Xin et al, they demonstrated that the combination of HGF and VEGF increases neovascularization in the rat corneal assay greater than either growth factor alone, suggesting that the two factors act synergistically and provide a more effective strategy for stimulating tubulogenesis through paracrine HGF secretion and amplifying the angiogenic response [1].…”

Section: Hgfmentioning

confidence: 99%

Angiogenesis and Tissue Repair Depend on Platelet Dosing and Bioformulation Strategies Following Orthobiological Platelet-Rich Plasma Procedures: A Narrative Review

Everts

Lana²,

Onishi³

et al. 2023

Biomedicines

View full text Add to dashboard Cite

Angiogenesis is the formation of new blood vessel from existing vessels and is a critical first step in tissue repair following chronic disturbances in healing and degenerative tissues. Chronic pathoanatomic tissues are characterized by a high number of inflammatory cells; an overexpression of inflammatory mediators; such as tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1); the presence of mast cells, T cells, reactive oxygen species, and matrix metalloproteinases; and a decreased angiogenic capacity. Multiple studies have demonstrated that autologous orthobiological cellular preparations (e.g., platelet-rich plasma (PRP)) improve tissue repair and regenerate tissues. There are many PRP devices on the market. Unfortunately, they differ greatly in platelet numbers, cellular composition, and bioformulation. PRP is a platelet concentrate consisting of a high concentration of platelets, with or without certain leukocytes, platelet-derived growth factors (PGFs), cytokines, molecules, and signaling cells. Several PRP products have immunomodulatory capacities that can influence resident cells in a diseased microenvironment, inducing tissue repair or regeneration. Generally, PRP is a blood-derived product, regardless of its platelet number and bioformulation, and the literature indicates both positive and negative patient treatment outcomes. Strangely, the literature does not designate specific PRP preparation qualifications that can potentially contribute to tissue repair. Moreover, the literature scarcely addresses the impact of platelets and leukocytes in PRP on (neo)angiogenesis, other than a general one-size-fits-all statement that “PRP has angiogenic capabilities”. Here, we review the cellular composition of all PRP constituents, including leukocytes, and describe the importance of platelet dosing and bioformulation strategies in orthobiological applications to initiate angiogenic pathways that re-establish microvasculature networks, facilitating the supply of oxygen and nutrients to impaired tissues.

show abstract

Section: Hgfmentioning

confidence: 99%

Angiogenesis and Tissue Repair Depend on Platelet Dosing and Bioformulation Strategies Following Orthobiological Platelet-Rich Plasma Procedures: A Narrative Review

Everts

Lana²,

Onishi³

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

“…It is also involved in the branching tubular morphogenesis of epithelial cells and ECs and induces angiogenesis [122]. HGF exhibits strong mitogenic properties that regulate the development and regeneration of tissues [123]. In vivo experiments by Xin et al demonstrated that the combination of HGF and VEGF increases neovascularization in the rat corneal assay greater than either growth factor alone, suggesting that the two factors act synergistically and provide a more effective strategy for stimulating tubulogenesis through paracrine HGF secretion and amplifying the angiogenic response [1].…”

Section: Hgfmentioning

confidence: 99%

Angiogenesis and Tissue Repair Depend on Platelet Dosing and Bioformulation Strategies Following Orthobiological Platelet-Rich Plasma Procedures. A Narrative Review

Everts¹,

Lana²,

Onishi³

et al. 2023

Preprint

View full text Add to dashboard Cite

Angiogenesis is new blood vessel formation from existing vessels and is a critical first step in tissue repair following chronic disturbances in healing and degenerative tissues. Chronic pathoanatomic tissues are characterized by a high number of inflammatory cells, overexpression of inflammatory mediators, such as tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1), the presence of mast cells, T cells, reactive oxygen species, and matrix metalloproteinases, and a decreased angiogenic capacity. Multiple studies have demonstrated that autologous orthobiological cellular preparations (e.g., platelet-rich plasma [PRP]) im-prove tissue repair and regenerate tissues. There are many PRP devices on the market. Unfortunately, they differ greatly in platelet numbers, cellular composition, and bioformulation. PRP is a platelet concentrate consisting of a high concentration of platelets with or without certain leukocytes, platelet-derived growth factors (PGFs), cytokines, molecules, and signaling cells. Several PRP products have immunomodulatory capacities that can influence resident cells in a diseased microenvironment, inducing tissue repair or re-generation. Generally, PRP is a blood-derived product, regardless of its platelet number and bioformulation, and the literature indicates both positive and negative patient treatment outcomes. Strangely, the literature does not designate specific PRP preparation qualifications that can potentially contribute to tissue re-pair. Moreover, the literature scarcely addresses the impact of platelets and leukocytes in PRP on (neo)angiogenesis other than a general one-size-fits-all statement that “PRP has angiogenic capabilities.” Here, we review the cellular composition of all PRP constituents, including leukocytes, and describe the importance of platelet dosing and bioformulation strategies in orthobiological applications to initiate angiogenic pathways that re-establish microvasculature networks, facilitating the supply of oxygen and nutrients to impaired tissues.

show abstract

Plasma HGF concentration in patients with brain tumorsRunning headline: HGF in patients with brain tumors

Cited by 2 publications

References 19 publications

Angiogenesis and Tissue Repair Depend on Platelet Dosing and Bioformulation Strategies Following Orthobiological Platelet-Rich Plasma Procedures: A Narrative Review

Angiogenesis and Tissue Repair Depend on Platelet Dosing and Bioformulation Strategies Following Orthobiological Platelet-Rich Plasma Procedures: A Narrative Review

Angiogenesis and Tissue Repair Depend on Platelet Dosing and Bioformulation Strategies Following Orthobiological Platelet-Rich Plasma Procedures. A Narrative Review

Contact Info

Product

Resources

About