Plasma granulysin levels and cellular interferon-γ production correlate with curative host responses in tuberculosis, while plasma interferon-γ levels correlate with tuberculosis disease activity in adults

Sahiratmadja, Edhyana; Alisjahbana, Bachti; Buccheri, Simona; Liberto, Diana Di; Boer, Tjitske de; Adnan, Iskandar; Crevel, Reinout van; Klein, Michél R.; Meijgaarden, Krista E. van; Nelwan, R.H.H.; Vosse, Esther van de; Dieli, Francesco; Ottenhoff, T.H.M.

doi:10.1016/j.tube.2007.01.002

Cited by 51 publications

(41 citation statements)

References 37 publications

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“…The tissue expression of granulysin correlated with the ability of the host to restrict infection in the mycobacterial disease leprosy (26). Plasma granulysin levels were found to correlate with host defense responses in human tuberculosis (49)(50)(51). Although granulysin is likely to contribute to host defense against microbial infection, it may also contribute to tissue injury by inducing necrosis of normal cells.…”

Section: Figurementioning

confidence: 98%

Anti-TNF immunotherapy reduces CD8+ T cell–mediated antimicrobial activity against Mycobacterium tuberculosis in humans

Bruns

Meinken²,

Schauenberg³

et al. 2009

J. Clin. Invest.

270

200

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The incidence of tuberculosis is increased during treatment of autoimmune diseases with anti-TNF antibodies. This is a significant clinical complication, but also provides a unique model to study immune mechanisms in human tuberculosis. Given the key role for cell-mediated immunity in host defense against Mycobacterium tuberculosis, we hypothesized that anti-TNF treatment impairs T cell-directed antimicrobial activity. Anti-TNF therapy reduced the expression in lymphocytes of perforin and granulysin, 2 components of the T cell-mediated antimicrobial response to intracellular pathogens. Specifically, M. tuberculosis-reactive CD8 + CCR7 -CD45RA + effector memory T cells (T EMRA cells) expressed the highest levels of granulysin, lysed M. tuberculosis, and infected macrophages and mediated an antimicrobial activity against intracellular M. tuberculosis. Furthermore, T EMRA cells expressed cell surface TNF and bound the anti-TNF therapeutic infliximab in vitro, making them susceptible to complement-mediated lysis. Immune therapy with anti-TNF was associated with reduced numbers of CD8 + T EMRA cells and decreased antimicrobial activity against M. tuberculosis, which could be rescued by the addition of CD8 + T EMRA cells. These results suggest that anti-TNF therapy triggers a reduction of CD8 + T EMRA cells with antimicrobial activity against M. tuberculosis, providing insight into the mechanism whereby key effector T cell subsets contribute to host defense against tuberculosis.

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Section: Figurementioning

confidence: 98%

Anti-TNF immunotherapy reduces CD8+ T cell–mediated antimicrobial activity against Mycobacterium tuberculosis in humans

Bruns

Meinken²,

Schauenberg³

et al. 2009

J. Clin. Invest.

270

200

View full text Add to dashboard Cite

show abstract

“…Erythrocyte sedimentation rate (ESR) and high-sensitive C-reactive protein (hs-CRP), non-specific inflammatory indices that are usually elevated in patients with TB [30][31][32], are correlated with disease activity and prognosis. We observed a significant correlation between the Tim-3 expression on NK cells and the ESR and hs-CRP, in healthy controls and Mtb-infected individuals (Fig.…”

Section: Blocking the Tim-3 Pathway Increases Nk Cell Cytotoxicity Agmentioning

confidence: 99%

Tim-3 pathway affects NK cell impairment in patients with active tuberculosis

Wang

Tang

et al. 2015

Cytokine

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“…Cytokine profiles during early TB treatment were also able to predict month-2 culture conversion and hold promise in predicting treatment outcome and future relapse (Walzl et al 2011;K Ronacher, unpubl.). Plasma granulysin levels also correlate with treatment response ( plasma granulysin levels and cellular IFN-g production correlate with curative host responses in TB, whereas plasma IFN-g levels correlate with TB disease activity in adults) (Sahiratmadja et al 2007).…”

Section: Biomarkers In Serum and Plasmamentioning

confidence: 99%