Plasma Glycoproteins in Malignant Disease

Macbeth, R. A.; Bekesi, J. George

doi:10.1001/archsurg.1964.01310220123019

Cited by 24 publications

(6 citation statements)

References 5 publications

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“…Abnormal increase in the level of plasma protein components has been related to the changes in hepatic cells during neoplastic transformation. Mecbeth and Bakesi, 1994 [ 29 ], postulated that the presence of tumor in hepatic cells induces the synthesis of glycoproteins, which subsequently appear in circulation. Large amounts of hexose, hexosamnine, and sialic acids were reported in many cancer conditions [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

Chemotherapeutic Efficacy ofIndigofera aspalathoideson 20-Methylcholanthrene-Induced Fibrosarcoma in Rats

2012

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The present study was undertaken to test the chemopreventive effects of one herbal medicinal plant, Indigofera aspalathoides, on chemically induced carcinogenesis in rats. A well-known polyaromatic hydrocarbon, namely, 20-methylcholanthrene, which is a known carcinogenic substance, was used to induce fibrosarcoma in Wistar strain of male albino rats. Fibrosarcoma rats were treated with aqueous extracts of Indigofera aspalathoides. The rats were divided into four groups, each consisting of six animals. Group I served as normal control, Group II served as fibrosarcoma-induced animals, Group III were fibrosarcoma-bearing animals treated with aqueous extracts of Indigofera aspalathoides, and Group IV animals, which were normal healthy animals treated with Indigofera aspalathoides aqueous extract, served as drug control set. Group III and Group IV animals were treated with aqueous extract of Indigofera aspalathoides intraperitoneally at a dose of 250 mg/kg. b.w. for 30 days. The fibrosarcoma was proved by pathological examinations. The activity levels of nucleic acids such as total DNA and RNA and hexose, hexosamine, and sialic acid in liver and kidney of treated rats were used to monitor the chemopreventive role of the plant extract. The observed increase in the levels of DNA, RNA, hexose, hexosamine, and sialic acid in liver and kidney tissues of fibrosarcoma-bearing animals reached near normal state after the treatment with aqueous extracts of Indigofera aspalathoides, suggesting that Indigofera aspalathoides does have a chemotherapeutic role.

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Section: Resultsmentioning

confidence: 99%

Chemotherapeutic Efficacy ofIndigofera aspalathoideson 20-Methylcholanthrene-Induced Fibrosarcoma in Rats

2012

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“…The decreased the levels of erythrocyte membrane glycoprotein may be due to the increased membrane degradation (36). Elevated levels of plasma glycoprotein concentration in tumor bearing animals can therefore be related to an increased synthesis in liver or tumor tissues itself with subsequent shedding into plasma (37). Previous studies in our laboratory reported that malignant cells have more sialic acid in their cell membrane than in normal cells.…”

Section: Discussionmentioning

confidence: 87%

Evaluation of chemopreventive effects of Thymoquinone on cell surface glycoconjugates and cytokeratin expression during DMBA induced hamster buccal pouch carcinogenesis

Rajkamal¹,

Suresh²,

Sugunadevi³

et al. 2010

BMB Reports

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The present study aimed to investigate the membrane stabilizing effect of Thymoquinone (TQ) on cell surface glycoconjugates and cytokeratin expression against DMBA induced hamster buccal pouch carcinogenesis. 0.5% DMBA painting (three times per week) in hamster buccal pouches for 14 weeks resulted in the formation of well developed oral squamous cell carcinoma. We observed 100% tumor formation with marked abnormalities of glycoconjugates status in tumor bearing hamsters as compared to control animals. Oral administration of TQ at a dose of 30 mg/kg body weight, to DMBA painted hamsters on alternate days for 14 weeks, reduced the tumor formation as well as protected the levels of cell surface glycoconjugates in DMBA painted hamsters. The present study thus suggests that TQ has potent chemopreventive efficacy as well as protected the abnormalities on cell surface glycoconjugates during DMBA induced hamster buccal pouch carcinogenesis [BMB reports 2010; 43(10): 664-669]

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“…Evidence from animal experiments suggests that the presence of malignant tumours invoke increased hepatic synthesis of glycoproteins that can then enter into the circulation [36]. Increase in glycoprotein has also been reported in hepatic neoplasm [37].…”

Section: Discussionmentioning

confidence: 99%

Protective role of allicin (diallyl thiosulfinate) on cell surface glycoconjugate moieties in 7,12-dimethylbenz(a) anthracene-induced oral carcinogenesis

Dhanarasu¹

2017

Trop. J. Pharm Res

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Plasma Glycoproteins in Malignant Disease

Cited by 24 publications

References 5 publications

Chemotherapeutic Efficacy ofIndigofera aspalathoideson 20-Methylcholanthrene-Induced Fibrosarcoma in Rats

Chemotherapeutic Efficacy ofIndigofera aspalathoideson 20-Methylcholanthrene-Induced Fibrosarcoma in Rats

Evaluation of chemopreventive effects of Thymoquinone on cell surface glycoconjugates and cytokeratin expression during DMBA induced hamster buccal pouch carcinogenesis

Protective role of allicin (diallyl thiosulfinate) on cell surface glycoconjugate moieties in 7,12-dimethylbenz(a) anthracene-induced oral carcinogenesis

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