Plasma glucagon-like peptide 1 and peptide YY levels are not altered in symptomatic fructose-sorbitol malabsorption

Valeur, Jørgen; Øines, Eliann; Holst, Jens J.; Berstad, Arnold

doi:10.1080/00365520802116448

Cited by 3 publications

(4 citation statements)

References 42 publications

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“…Hence, intestinal hydrogen gas production as measured by hydrogen excretion in exhaled air does not explain carbohydrate-induced symptoms in our patients. This finding is in accordance with previous findings of others [18] and of our group [6][7][8]. Since only a fraction of the gas produced in the intestines is excreted via the lungs [19], it is possible that a 3-h quantification of exhaled gas post-challenge is a poor estimate of the actual gas production throughout the following day.…”

Section: Discussionsupporting

confidence: 93%

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Carbohydrate intolerance in patients with self-reported food hypersensitivity: Comparison of lactulose and glucose

Valeur

Norin

Midtvedt

et al. 2009

Scandinavian Journal of Gastroenterology

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Section: Discussionsupporting

confidence: 93%

“…They were thoroughly examined, and food allergies and other organic gastrointestinal diseases were ruled out by methods described previously [8]. Exclusion criteria were age < 18 years, pregnancy/lactation, organic gastrointestinal disease and prior use of antibiotics (in the past month).…”

Section: Patients and Controlsmentioning

confidence: 99%

Carbohydrate intolerance in patients with self-reported food hypersensitivity: Comparison of lactulose and glucose

Valeur

Norin

Midtvedt

et al. 2009

Scandinavian Journal of Gastroenterology

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“…They were thoroughly examined, and food allergies and other organic gastrointestinal diseases were ruled out by methods as described previously 7. Exclusion criteria were age below 18 years, pregnancy/lactation, organic gastrointestinal disease, and prior use of antibiotics (past month).…”

Section: Methodsmentioning

confidence: 99%

Intestinal fermentation in patients with self-reported food hypersensitivity: painful, but protective?

Valeur

Norin²,

Midtvedt³

et al. 2010

CEG

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Purpose:Enterometabolic disturbances may cause meal-related symptoms. We performed a functional evaluation of the intestinal microflora in patients with unexplained, self-reported food hypersensitivity by measuring fecal short-chain fatty acids (SCFAs).Patients and methods:Thirty-five consecutive patients with self-reported food hypersensitivity and 15 healthy volunteers of similar age, gender, and body mass index collected all feces for 72 hours. Fecal concentrations of acetic, propionic, n-butyric, i-butyric, n-valeric, i-valeric, n-caproic, and i-caproic acids were analyzed by gas-liquid chromatography. Concentrations and excretions (output) of SCFAs in patients and controls were compared and related to gastrointestinal symptoms.Results:Despite nonsignificant differences between patients and controls for both total and individual SCFA concentrations and excretions, n-butyric acid comprised a higher (P = 0.035) and acetic acid a lower (P = 0.012) proportion of total SCFA in patients compared to controls. There were no significant correlations between symptom scores and concentrations or excretions of individual or total SCFAs, but the proportion of n-butyric acid was significantly higher in patients with severe symptoms compared to patients with moderate symptoms (P = 0.016).Conclusion:The results indicate an enterometabolic disturbance in patients with self-reported food hypersensitivity. Higher proportions of n-butyric acid may be related to abdominal symptom generation, but may also protect against organic bowel disease. Further studies are needed to clarify these aspects.

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“…Nevertheless, the consequence of carbohydrate malabsorption seems to be a general, dose-dependent and additive phenomenon, seemingly reflecting some shared, group-based properties of all fermentable carbohydrates that escape small intestinal absorption [63]. Although there is evidence to suggest that ingestion of LDC is beneficial, LDC malabsorption seems to be poorly tolerated by patients with unexplained, self-reported food hypersensitivity [4,64].…”

Section: Studies On Intestinal Fermentationmentioning

confidence: 99%

Perceived food hypersensitivity: A review of 10 years of interdisciplinary research at a reference center

Lied

Lillestøl

Lind

et al. 2011

Scandinavian Journal of Gastroenterology

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Perceived food hypersensitivity is a prevalent, but poorly understood condition. In this review article, we summarize narratively recent literature including results of our 10 years' interdisciplinary research program dealing with such patients. The patients (more than 400) included in our studies were all adults referred to a university hospital because of gastrointestinal complaints self-attributed to food hypersensitivity. Despite extensive examinations, food allergy was seldom diagnosed. The majority of the patients fulfilled the diagnostic criteria for irritable bowel syndrome. In addition, most suffered from several extra-intestinal health complaints and had considerably impaired quality of life. However, psychological factors could explain only approximately 10% of the variance in the patients' symptom severity and 90% of the variance thus remained unexplained. Intolerance to low-digestible carbohydrates was a common problem and abdominal symptoms were replicated by carbohydrate ingestion. A considerable number of patients showed evidence of immune activation by analyses of B-cell activating factor, dendritic cells and "IgE-armed" mast cells. Multiple factors such as immune activation, disturbed intestinal fermentation, enteric dysmotility, post-infectious changes and "local" allergy in the gut as well as psychological disturbances may play a role in the pathophysiology of perceived food hypersensitivity. Hence, our results support the view that management of these patients should be interdisciplinary.

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Plasma glucagon-like peptide 1 and peptide YY levels are not altered in symptomatic fructose-sorbitol malabsorption

Cited by 3 publications

References 42 publications

Carbohydrate intolerance in patients with self-reported food hypersensitivity: Comparison of lactulose and glucose

Carbohydrate intolerance in patients with self-reported food hypersensitivity: Comparison of lactulose and glucose

Intestinal fermentation in patients with self-reported food hypersensitivity: painful, but protective?

Perceived food hypersensitivity: A review of 10 years of interdisciplinary research at a reference center

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