Plasma Ghrelin Concentrations Are Negatively Correlated With Urine Albumin-to-Creatinine Ratio in Newly Diagnosed Type 2 Diabetes

Relation of Plasma Obestatin Levels with BMI and HOMA-IR in Syrian Obese Patients with Type 2 Diabetes

“…However, these findings were in agreement with a previous study (Qi et al 2007), which found that obestatin levels correlated inversely and significantly with BMI (P = 0.035), insulin (P = 0.003) and HOMA-IR (P = 0.031) values, and did not correlate significantly with age (P = 0.162) nor glucose (P = 0.162) in diabetic patients (but their patients were not obese) [20] A study by Ma et al 2014 found that plasma obestatin concentrations in diabetic patients were significantly lower than those in normal glucose tolerance subjects. This is consistent with our results, although, all their subjects were middle-aged (41-64 years) and old (65-76 years) and they were not obese, and they showed that plasma ghrelin was negatively associated with fasting glucose and Urine Albumin-to-Creatinine Ratio (UACR), so that the lower ghrelin levels might be a potential indicator for renal dysfunction in patients with T2D [21].…”

“…This is consistent with our results, although, all their subjects were middle-aged (41-64 years) and old (65-76 years) and they were not obese, and they showed that plasma ghrelin was negatively associated with fasting glucose and Urine Albumin-to-Creatinine Ratio (UACR), so that the lower ghrelin levels might be a potential indicator for renal dysfunction in patients with T2D [21].…”

Ghrelin in Serum and Urine of Post-Partum Women with Gestational Diabetes Mellitus

“…Many studies have suggested that changes in the circulating ghrelin levels reflect an individual’s nutritional status [ 40 , 41 , 42 ]. It was established that ghrelin is a negative regulator of insulin secretion, and the ghrelin signaling pathway plays an important role in glucose homeostasis [ 43 , 44 ]. These data identified the ghrelin–glucose–lipid metabolism interaction as a key homeostatic process modulating energy balance [ 44 ].…”

Diabetes and cancer: Findings from the REACTION study 糖尿病与恶性肿瘤：来自REACTION研究的发现

“…Reports thus far have shown associations of ages at menarche and at menopause with cardiovascular disease, diabetes, and osteoporosis, associations between sleep duration, daytime nap duration, and osteoporosis varying by sex, menopause and sleep quality, associations of green tea and rock tea consumption with risk of impaired fasting glucose and impaired glucose tolerance, and an association between serum uric acid levels and cardiovascular disease . Several inflammatory cytokines have been reported to be associated with the urinary albumin‐to‐creatinine ratio or hypertension in the Chinese population . Using the community‐based survey data, the REACTION group also established several diagnostic criteria, including HbA1c cut‐off points, for the diagnosis of diabetes and prediabetes in a middle‐aged and elderly Han population from northwest China, a Chinese risk score model for identifying postprandial hyperglycemia without an oral glucose tolerance test, and optimal waist circumference cut‐off values for identifying metabolic risk factors in middle‐aged and elderly subjects in Shandong Province of China…”

“…REACTION队列研究具有如下优势：大样本人群，足以代表中国不同地区的情况并提供了足够的数据分析效能；该研究拥有强大的领导团体及研究团队，精良的基础设施和测试设备；个人问卷调查采集了具体的风险因素；在基线水平制定了详细的物理及生化指标，包括人口学参数、空腹及餐后2小时血糖和胰岛素、脂代谢水平等；恰当收集和保存了基线的血液及尿液标本以备后续对生物标记物的研究测定。该研究为各领域研究糖尿病及恶性肿瘤相关的重要问题的工作者提供了一个资源丰富的平台。通过对基线横断面数据的分析，REACTION研究组探讨了糖尿病及其他代谢性疾病的一系列危险因素。报道揭示了月经初潮及停经年龄与心血管疾病、糖尿病及骨质疏松之间的关联 9 ，不同的性别、停经情况和睡眠质量下的睡眠时间、白天小睡时间与骨质疏松的关系 10 ，绿茶、红茶的饮用与空腹葡萄糖调节受损及葡萄糖耐量受损的关系 11 ，以及血清尿酸水平与心血管疾病之间的关系 12 。据报道一些炎症细胞因子与中国人群的尿白蛋白/肌酐比值或高血压相关 13,14 。通过对社区人群数据的分析，REACTION研究组也建立了一些诊断标准，包括在中国西北地区中老年汉族人群中寻找糖化血红蛋白对糖尿病及糖尿病前期的诊断切点 15 ，替代糖耐量试验识别中国人餐后高血糖的风险评分模型 16 ，以及在中国山东省中老年人群中诊断代谢综合征的腰围最佳切点 17 。…”