“…For example, peptide-type inhibitors include hanatoxin, guangxitoxin-1E, heteroscordratoxins, ScTx-1, SGTx1, syntaxin-1A, SsmTx-I and plasma gelsolin. 30 , 31 , 32 , 33 , 34 , 35 , 36 Small molecular inhibitors galantamine and isoliquiritigenin block Kv2.1 currents with little data on GSIS or cell apoptosis; 37 , 38 RY796 and C-1 enhance GSIS; 8 , 9 donepezil and 48F10 abolish neuronal apoptosis. 39 , 40 Previously, we reported natural product vindoline functioned in promotion of both insulin secretion and β -cell protection.…”