Plasma gelsolin improves lung host defense against pneumonia by enhancing macrophage NOS3 function

Yang, Zhiping; Chiou, Terry Ting-Yu; Stossel, Thomas P.; Kobzik, Lester

doi:10.1152/ajplung.00094.2015

Cited by 44 publications

(52 citation statements)

References 30 publications

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“…However, a previous study showed that plasma GSN improves host lung defense against pneumonia by enhancing macrophage NOS3 function [31]. We suggest that the functions of macrophages inhibited or enhanced by GSN are dependent on the specific inflammatory scenario.…”

Section: Discussionmentioning

confidence: 70%

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Gelsolin Inhibits the Inflammatory Process Induced by LPS

Cheng

Liu

et al. 2017

Cell Physiol Biochem

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Background/Aims: Endotoxemia is a life-threatening situation that signifies a key challenge in the field of intensive care medicine. Proinflammatory mediators produced by macrophages play a key role in endotoxemia. Gelsolin (GSN) is involved in the process of inflammation. Methods: IL-6 and TNF-α in the supernatant were measured with an ELISA kit. NO production was assessed by measurement of nitrite concentration with the Griess assay. si-RNA directed against GSN (si-GSN) was transfected by Lipofectamine. Results: LPS decreased the levels of GSN. Recombinant GSN inhibited the cytokines induced by LPS and rescued mice from LPS-induced death, and si-GSN increased death in the LPS-pretreated mice. Conclusion: GSN exhibited a protective role in endotoxemia.

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Section: Discussionmentioning

confidence: 70%

“…GSN is required for macrophage recruitment during re-myelination of the peripheral nervous system [16], and plasma gelsolin improves lung defense against pneumonia by enhancing macrophage NOS3 function [17]. The relationship between macrophages and GSN is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Gelsolin Inhibits the Inflammatory Process Induced by LPS

Cheng

Liu

et al. 2017

Cell Physiol Biochem

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“…Serum proteins in the alveoli that inhibit surfactant activity (21), together with the paucity of phospholipids, creates mechanical stress that causes parenchymal damage. Many of the serum proteins identified in BALF recruit and activate inflammatory cells (26,27). Thus, both mechanical forces and inflammation likely contribute to the alveolitis and ensuing respiratory failure seen after the loss of ABCA3.…”

Section: Discussionmentioning

confidence: 99%

“…AGER, S100A9, CD14, IL1RAP, SPP1, and SerpinA1 mediate macrophage or neutrophil recruitment and activation, whether derived from inflammatory or parenchymal cells (28)(29)(30)(31)(32). Serum proteins that activate macrophages were present in the BALF, including albumin, AGT, SerpinF1, GSN, GC, HRG, and KNG1 (27,(33)(34)(35). RNA analysis of isolated alveolar epithelial cells from the Abca3-deleted mice indicated increased expression of RNAs associated with cell injury and induced inflammatory response, including IL-33.…”

Section: Discussionmentioning

confidence: 99%

Alveolar injury and regeneration following deletion of ABCA3

Rindler¹,

Stockman²,

Filuta³

et al. 2017

JCI Insight

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“…Recently, Yang et al found that Plasma gelsolin improves lung host defense against pneumonia by enhancing macrophage NOS3 function. [14].…”

Section: Introductionmentioning

confidence: 99%

Genetic Regulation of Gelsolin in Lung in Mouse Model and its Potential Broad Spectrum of Biological Functions

Liu¹,

Feng²,

Zhu³

et al. 2016

Immunome Res

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Considerable studies have been done on the potential biological function of gelsolin and its connection to human immune system, diseases and other disorders. The objective of our study was to identify genetic factors that regulate gelsolin in mouse lung and analyze its function immune system using well defined recombinant inbred strains. For this purpose we chose the BXD recombinant inbred (RI) strains derived from progeny of the C57BL/6J (B6) and DBA/2J (D2) progenitor strains. Whole genome gene expression in lung was used for the eQTL mapping. Bioinformatics tools and genotyping data were used for the candidate gene analysis. Gene network and correlation processes were used to assess the association between gelsolin and biological traits. Data indicated that an eQTL on chromosome 9 covering a genomic area between 21Mb and 30Mb is a major play in regulation of the gelsolin expression level. Analysis of genetic elements within this region revealed that Ncapd3 is the most favorite candidate gene. Its expression level is highly associated to that of gelsolin. The expression level of gelsolin between mouse strains with two genotype of SNP (rs13480109) in a regulatory region of the Ncapd3 showed a significant difference. Additional association analysis suggest that gelsolin may has a broad spectrum of biological function. The expression level of gelsolin has very high correlation with genes in a variety of biological function. These highly associated genes are mainly for protein binding. The expression of gelsolin is also correlated to multiple known immune phenotypes. These data contribute significantly to our current knowledge on the biological function of gelsolin.

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Plasma gelsolin improves lung host defense against pneumonia by enhancing macrophage NOS3 function

Abstract: Yang Z, Chiou TT, Stossel TP, Kobzik L. Plasma gelsolin improves lung host defense against pneumonia by enhancing macrophage NOS3 function.

Cited by 44 publications

References 30 publications

Gelsolin Inhibits the Inflammatory Process Induced by LPS

Gelsolin Inhibits the Inflammatory Process Induced by LPS

Alveolar injury and regeneration following deletion of ABCA3

Genetic Regulation of Gelsolin in Lung in Mouse Model and its Potential Broad Spectrum of Biological Functions

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