Plasma galanin response to head-up tilt in normal subjects and patients with recurrent vasovagal syncope

Bondanelli, Marta; Alboni, Paoló; Margutti, Angelo; Franceschetti, Paola; Dinelli, Maurizio; Gruppillo, P; Marchi, Paola; Uberti, Ettore C. degli

doi:10.1053/meta.2003.50051

Cited by 14 publications

(23 citation statements)

References 30 publications

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“…The secretion patterns of both peptides during HUTT were compared to a group of healthy individuals. The authors are not aware of any other HUTT trial without pharmacological provocation performed on rVVS patients while measuring ADM levels though a case/control study exists 14 evaluating GAL levels in patients with rVVS during HUTT. In another trial 15 , adrenomedullin response to HUTT in VVS patients was assessed.…”

Section: Resultsmentioning

confidence: 99%

“…However, in most patients, the syncope was induced by nitroglycerin administration, and the condition of syncope recurrence was not satisfied. Bondanelli et al 14 show that GAL levels increase in rVVS patients who do not develop a syncope (negative HUTT), whereas it remains unchanged in rVVS patients who develop a syncope (positive HUTT). GAL levels are reported to remain unchanged in the control group but there were no positive responses to the HUTT in this group 14 .…”

Section: Resultsmentioning

confidence: 99%

“…Bondanelli et al 14 show that GAL levels increase in rVVS patients who do not develop a syncope (negative HUTT), whereas it remains unchanged in rVVS patients who develop a syncope (positive HUTT). GAL levels are reported to remain unchanged in the control group but there were no positive responses to the HUTT in this group 14 . This suggests that GAL could be responsible for preventing a syncope development in susceptible individuals.…”

Section: Resultsmentioning

confidence: 99%

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The role of adrenomedullin and galanin in recurrent vasovagal syncope: a case control study

Plášek¹,

Doupal²,

Fürstová³

et al. 2013

BIOMED PAP

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Aims. Orthostatic stimuli are known to elicit changes in vasoactive peptide levels. The hypothesis of no difference in adrenomedullin and/or galanin levels in patients with recurrent vasovagal syncope and healthy controls was tested in a passive 35-min head-up tilt test (HUTT). Methods. Twenty eight persons (14 patients and 14 healthy controls) were tested in a 35-min/60° head-up tilt test with telemetry monitoring. Three blood samples were evaluated for each person during the HUTT. Plasma levels of adrenomedullin and galanin were analysed by the Kruskal-Wallis test for all sampling periods. Vagal influence was indirectly assessed by the break index.Results. There were no significant differences between groups in median values for either adrenomedullin or galanin plasma levels (all 6 p-values were greater than 0.4). For adrenomedullin, no significant difference between groups was found. For galanin, the rate of change between the 1st and 2nd measurement was significantly greater for patients (P=0.04), regardless of HUTT result but between the 2 nd and 3 rd measurement it was insignificant (P=0.36). In the group of positive cases, the break index increased significantly (P=0.02). Conclusion. We confirmed that there is a different galanin secretion pattern during orthostatic provocation in patients with recurrent vasovagal syncope than healthy individuals. For adrenomedullin, no significant difference was found. A significant increment of the break index confirmed increased vagal influence in the subgroup of positive cases.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The role of adrenomedullin and galanin in recurrent vasovagal syncope: a case control study

Plášek¹,

Doupal²,

Fürstová³

et al. 2013

BIOMED PAP

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“…In this regard, changes in circulatory catecholamines have tended to be of greatest interest given the apparent association of VVS with anxiety or stress states [8][9][10][11][12][13][14]. However, the potential role of NPs has also attracted attention; specifically, BNP [8], vasopressin (VP) [8,15,16], atrial natriuretic peptide (ANP) [8,17], adrenomedullin (ADM) [17][18][19], galanin (GAL) [19,20], and endothelin-1 (ET-1) [17,[21][22][23]. A summary of the primary physiologic effects of these NPs is shown in Table 2.…”

Section: Neuropeptides and Peptide Hormones In The Pathophysiology Ofmentioning

confidence: 99%

“…Bondanelli et al [19] examined plasma GAL changes during head-up tilt test (HUTT) in healthy subjects and patients with recurrent VVS. In healthy control subjects, GAL did not change during HUTT.…”

Section: Galaninmentioning

confidence: 99%

Neuropeptides and peptide hormones in syncope and orthostatic intolerance

Krishnan

Benditt

2014

Cardiol J

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Left Ventricular Ejection Fraction and Fractional Shortening are Useful for the Prediction of the Therapeutic Response to Metoprolol in Children with Vasovagal Syncope

Song

Wang

et al. 2018

Pediatr Cardiol

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The objective of this manuscript was to explore if left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) could predict the efficacy of metoprolol therapy on vasovagal syncope (VVS) in children. Forty-nine children, including 30 with VVS and 19 gender- and age-matched healthy controls, were included in the study. Metoprolol was prescribed to the VVS subjects. The clinical data were obtained during follow-up at 2 and 6 months. The results showed that LVEF and LVFS of responders were significantly higher than those of non-responders both at the 2-month follow-up (LVEF: 72.5 ± 3.2% vs. 64.6 ± 3.4%; LVFS: 40.9 ± 2.3% vs. 34.9 ± 2.9%), and at the 6-month follow-up (LVEF: 72.8 ± 2.8% vs. 65.5 ± 4.6%; LVFS: 41.1 ± 1.9% vs. 35.8 ± 3.6%). The receiver operating characteristic curve (ROC) analysis demonstrated that 70.5% as a cutoff value of baseline LVEF yielded a sensitivity of 80% and a specificity of 100% in predicting the therapeutic effectiveness of metoprolol at 2 months. For baseline LVFS, 38.5% as a cutoff value yielded a sensitivity of 90% and a specificity of 90%. At the 6-month follow-up, the ROC analysis demonstrated that 70.5% as a cutoff value of baseline LVEF yielded a sensitivity of 81.3% and a specificity of 88.9% in the prediction of metoprolol efficacy. For baseline LVFS, 37.5% as a cutoff value yielded a sensitivity of 93.8% and a specificity of 66.7%. In conclusion, baseline LVEF and LVFS might be useful predictors of the efficacy of β-blocker therapy on VVS in children.

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Plasma galanin response to head-up tilt in normal subjects and patients with recurrent vasovagal syncope

Cited by 14 publications

References 30 publications

The role of adrenomedullin and galanin in recurrent vasovagal syncope: a case control study

The role of adrenomedullin and galanin in recurrent vasovagal syncope: a case control study

Neuropeptides and peptide hormones in syncope and orthostatic intolerance

Left Ventricular Ejection Fraction and Fractional Shortening are Useful for the Prediction of the Therapeutic Response to Metoprolol in Children with Vasovagal Syncope

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