Plasma Free Fatty Acids, Inhibitor of Extrathyroidal Conversion of T4 to T3 and Thyroid Hormone Binding Inhibitor in Patients with Various Nonthyroidal Illnesses.

Suzuki, Yoshikazu; Nanno, Masataka; Gemma, Rieko; Takai, Yoshimi

doi:10.1507/endocrj1954.39.445

Cited by 11 publications

(3 citation statements)

References 20 publications

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“…Large amounts of inflammatory factors released during the onset of acute cardiocerebrovascular diseases may participate in TSH regulation [17]. (3) Increased intracranial pressure or cerebral circulation dysfunction due to cerebral edema during acute stroke may cause abnormal pituitary hormone secretion, leading to abnormal TSH secretion [18]. (4) The hypothalamus–pituitary–thyroid axis determines all steps of TH biosynthesis and secretion [19].…”

Section: Discussionmentioning

confidence: 99%

Correlation analysis of serum thyroid stimulating hormone with acute cerebrovascular disease

Zhu¹,

Chen

et al. 2019

Eur J Med Res

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BackgroundAcute cerebrovascular disease (ACVD) could cause abnormal metabolism of thyroid hormones (TH), mostly represented as a euthyroid sick syndrome or low T3 syndrome. However, the changes in serum thyroid-stimulating hormone (TSH) are controversial. The aim of this study is to investigate the clinical significance of TSH alteration in patients with ACVD.MethodPatients with ACVD admitted in our hospitals between January 2013 and September 2017 were enrolled in this study (n = 245, including 176 cerebral infarctions and 69 cerebral hemorrhages). Their thyroid hormones were measured and compared with healthy individuals (n = 75). The correlation of TSH with severity and prognosis of ACVD were analyzed by receiver operating characteristic curve.ResultsSerum TSH in ACVD group was higher than the control group (1.64 ± 1.08 vs. 1.26 ± 0.36 μIU/mL, P < 0.05). The TSH levels in intermediate and severe patients with ACVD were higher than in mild patients (1.72 ± 1.18 vs. 2.71 ± 0.93 vs. 1.02 ± 0.47 μIU/mL, P < 0.05). Receiver Operating Characteristic curve (ROC) of TSH in determining the severity of patients were 0.863 (Area under the curve, AUC), 1.496 μIU/L (optimal threshold), 76.5% (sensitivity) and 87.3% (specificity). TSH levels in improved and unchanged groups were significantly higher than the primarily healing group (2.27 ± 1.11 vs. 2.88 ± 1.07 vs. 0.86 ± 0.46 μIU/mL, P < 0.05). ROC of TSH in determining the prognosis of patients was 0.910 (AUC), 1.681 mIU/L (optimal threshold), 79.8% (sensitivity) and 90.5% (specificity) correspondingly.ConclusionSince elevated TSH in ACVD patients affects the outcome of thyroid function evaluation, it is preferable to re-check after the acute period. A correlation between a high TSH level and the severity and prognosis of ACVD was detected, but the mechanism of this correlation needs to be further studied.

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Section: Discussionmentioning

confidence: 99%

Correlation analysis of serum thyroid stimulating hormone with acute cerebrovascular disease

Zhu¹,

Chen

et al. 2019

Eur J Med Res

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“…These hormones mainly triiodothyronine (T3) and thyroxine (T4), circulate in the bloodstream, with T3 primarily deriving from the conversion of T4 through the action of deiodinase iodothyronine enzymes in peripheral tissues.While both hormones exert biological effects, T3 is considered asthe more potent of the two 2 . Research findings indicate that reduced free T3 levels and elevated levels of thyroid-stimulating hormone (TSH) are linked to a poorer prognosis in heart failure patients, even in the absence of clinically apparent thyroid disorders 3,4 .…”

Section: Introductionmentioning

confidence: 99%

The prognostic value of free triiodothyronine/free thyroxine ratio in short-term outcomes after left ventricular assist device implantation

Yazar,

Hakgör

2024

Dicle Tıp Dergisi

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Background: Despite advancement in technology adverse events after left ventricular assist device(LVAD) implantation continue to be the main barrier to more widespread use of it. Therefore, it is vital to identify prognostic factors to reduce adverse cardiac events after LVAD implatation. Thyroid dysfunction is associated with a poor prognosis in individuals with heart failure. The objective of this study is to examine the correlation between thyroid hormones and adverse cardiovascular events following LVAD implantation. Method and Results: The study included a total of 36 patients, with an average age of 60 ± 9 years, of which 77.7% were male. Although there was no significant relationship between TSH and FT3 levels and post-operative adverse events(p>0.05 for both), there was a significant association between FT3/FT4 and all-cause and cardiovascular mortality(p0.05 for all). All-cause mortality, cardiac mortality, arrhythmia prevelance, vasopressor need(day) and duration of ICU stay were significantly higher in FT3/FT4 < 1 group(all p < 0.05). Conclusion: Our findings suggest that FT3/FT4 ratio might be useful as a biomarker of short-term adverse clinical outcomes in patients who underwent LVAD implantation.

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“…Na década de 60 surgiram vários estudos que demonstraram alterações nas dosagens séricas dos hormônios tiroidianos em patologias não-tiroidianas (14,28) . Desde então, outros trabalhos foram publicados descrevendo doenças sistêmicas agudas ou crônicas, acompanhadas ou não por desnutrição e caquexia, nas quais o perfeito entendimento da função tiroidiana não era simples, pois havia alterações dos níveis hormonais no sangue, independentemente da presença de patologia endócrina (11,12,18,37) . Anormalidades dos testes de função tiroidiana em associação com doenças hepáticas têm sido descritas por vários autores (2,4,6,15,16,25,27,28,32,33,35) em todos os níveis do eixo hipotálamo-hipófise-tiróide, assim como no transporte e metabolismo periférico dos hormônios tiroidianos.…”

Section: Introductionunclassified

Teste da função tiroidiana na hepatite crônica viral

Novis

Coelho

2001

Arq. Gastroenterol.

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Plasma Free Fatty Acids, Inhibitor of Extrathyroidal Conversion of T4 to T3 and Thyroid Hormone Binding Inhibitor in Patients with Various Nonthyroidal Illnesses.

Abstract: Abstract.In order to clarify

Cited by 11 publications

References 20 publications

Correlation analysis of serum thyroid stimulating hormone with acute cerebrovascular disease

Correlation analysis of serum thyroid stimulating hormone with acute cerebrovascular disease

The prognostic value of free triiodothyronine/free thyroxine ratio in short-term outcomes after left ventricular assist device implantation

Teste da função tiroidiana na hepatite crônica viral

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