Plasma fibrinogen and lung function: the CARDIA Study

Thyagarajan, Bharat; Jacobs, David R.; Apostol, George; Smith, Lewis J.; Lewis, Cora E.; Williams, O. Dale

doi:10.1093/ije/dyl049

Cited by 79 publications

(95 citation statements)

References 34 publications

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“…In accordance with the present findings, SHAABAN et al [13] found an association between CRP at baseline and a decline in FEV1 in middle-aged subjects (average age 37 yrs) over a follow-up period of 8.5 yrs, although this association did not reach formal significance (p50.07). Additionally, plasma fibrinogen, another marker of systemic inflammation, was found to predict subsequent lung function decline in a 5-yr follow-up study of young American adults [12]. This indicates that different markers of systemic inflammation may be similar in predicting changes in lung function.…”

Section: Discussionmentioning

confidence: 85%

“…The temporal relationship between systemic inflammation and poor lung function is also unclear. Although several studies have explored this association [1,[10][11][12][13][14][15], each of these studies had certain limitations. Some of these studies were cross sectional in nature and unable to assess the temporal relationships [10,11].…”

mentioning

confidence: 99%

“…Longitudinal studies have found that lung function decline was associated with raised levels of CRP at follow-up, but found little or no evidence that high levels of CRP predicted a subsequent decline in lung function. However, these studies have mostly been conducted in middle-aged individuals [13] or elderly subjects [1,15]; highsensitivity CRP measurements were not used on both occasions and the influence of low-grade inflammation may have been missed [12,14].…”

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confidence: 99%

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High-sensitive C-reactive protein is associated with reduced lung function in young adults

Rasmussen¹,

Mikkelsen²,

Hancox³

et al. 2008

European Respiratory Journal

104

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Systemic inflammation has been associated with reduced lung function. However, data on the interrelationships between lung function and inflammation are sparse, and it is not clear if low-grade inflammation leads to reduced lung function.Associations between high-sensitive C-reactive protein (CRP) and spirometric lung function were assessed in a population-based cohort of ,1,000 Danes aged 20 yrs.In males, the average decline in forced expiratory volume in one second (FEV1) in the highest CRP quintile was 23 mL?yr -1 versus 1.6 mL?yr -1 in the lowest quintile. In females, the average decline was 6.2 mL?yr -1 in the highest CRP quintile versus an increase of 1.8 mL?yr -1 in the lowest CRP quintile. In a multiple regression analysis adjusted for sex, body mass index, cardiorespiratory fitness, smoking, asthma, airway hyperresponsiveness and serum eosinophil cationic protein, higher levels of CRP at age 20 yrs were associated with a greater reduction in both FEV1 and forced vital capacity between ages 20 and 29 yrs. The findings show that higher levels of C-reactive protein in young adults are associated with subsequent decline in lung function, suggesting that low-grade systemic inflammation in young adulthood may lead to impaired lung function independently of the effects of smoking, obesity, cardiorespiratory fitness, asthma and eosinophilic inflammation.

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Section: Discussionmentioning

confidence: 85%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

High-sensitive C-reactive protein is associated with reduced lung function in young adults

Rasmussen¹,

Mikkelsen²,

Hancox³

et al. 2008

European Respiratory Journal

104

View full text Add to dashboard Cite

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“…Both diseases have been related to systemic inflammation [16][17][18][19][20]. Individuals with airflow limitation demonstrate airway and systemic inflammation, depending on the severity of lung disease, physical fitness and potential comorbidities [17][18][19]. Besides smoking [21] and obesity [22], risk factors for lung function decline and airflow limitation are ageing and pulmonary diseases, such as chronic obstructive pulmonary disease (COPD) [23].…”

Section: Introductionmentioning

confidence: 99%

Periodontitis is related to lung volumes and airflow limitation: a cross-sectional study

et al. 2012

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This study aimed to assess the potential association of periodontal diseases with lung volumes and airflow limitation in a general adult population.Based on a representative population sample of the Study of Health in Pomerania (SHIP), 1463 subjects aged 25-86 years were included. Periodontal status was assessed by clinical attachment loss (CAL), probing depth and number of missing teeth. Lung function was measured using spirometry, body plethysmography and diffusing capacity of the lung for carbon monoxide. Linear regression models using fractional polynomials were used to assess associations between periodontal disease and lung function. Fibrinogen and high-sensitivity C-reactive protein (hs-CRP) were evaluated as potential intermediate factors.After full adjustment for potential confounders mean CAL was significantly associated with variables of mobile dynamic and static lung volumes, airflow limitation and hyperinflation (p,0.05). Including fibrinogen and hs-CRP did not change coefficients of mean CAL; associations remained statistically significant. Mean CAL was not associated with total lung capacity and diffusing capacity of the lung for carbon monoxide. Associations were confirmed for mean probing depth, extent measures of CAL/probing depth and number of missing teeth.Periodontal disease was significantly associated with reduced lung volumes and airflow limitation in this general adult population sample. Systemic inflammation did not provide a mechanism linking both diseases. @ERSpublications Periodontal disease was significantly associated with reduced lung volumes and airflow limitation in an adult population

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“…However, fibrin is also detected along the luminal surface of distal airways in patients dying from asthma (Wagers et al 2004). Inverse association exists between lung function and blood levels of fibrinogen (Thyagarajan et al 2006, Huang et al 2012. Although the effect of fibrin on ASM is undefined, mice lacking fibrinogen demonstrate an attenuated AHR in the context of allergic airway inflammation (Riesenfeld et al 2012).…”

Section: Blood-derived Factorsmentioning

confidence: 99%

Endocrine regulation of airway contractility is overlooked

Bossé

2014

Journal of Endocrinology

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Asthma is a prevalent respiratory disorder triggered by a variety of inhaled environmental factors, such as allergens, viruses, and pollutants. Asthma is characterized by an elevated activation of the smooth muscle surrounding the airways, as well as a propensity of the airways to narrow excessively in response to a spasmogen (i.e. contractile agonist), a feature called airway hyperresponsiveness. The level of airway smooth muscle (ASM) activation is putatively controlled by mediators released in its vicinity. In asthma, many mediators that affect ASM contractility originate from inflammatory cells that are mobilized into the airways, such as eosinophils. However, mounting evidence indicates that mediators released by remote organs can also influence the level of activation of ASM, as well as its level of responsiveness to spasmogens and relaxant agonists. These remote mediators are transported through circulating blood to act either directly on ASM or indirectly via the nervous system by tuning the level of cholinergic activation of ASM. Indeed, mediators generated from diverse organs, including the adrenals, pancreas, adipose tissue, gonads, heart, intestines, and stomach, affect the contractility of ASM. Together, these results suggest that, apart from a paracrine mode of regulation, ASM is subjected to an endocrine mode of regulation. The results also imply that defects in organs other than the lungs can contribute to asthma symptoms and severity. In this review, I suggest that the endocrine mode of regulation of ASM contractility is overlooked.

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Plasma fibrinogen and lung function: the CARDIA Study

Abstract: These findings are consistent with the hypothesis that fibrinogen, possibly as a marker for chronic low-grade inflammation, is associated with modest deterioration of lung function in healthy young adults.

Cited by 79 publications

References 34 publications

High-sensitive C-reactive protein is associated with reduced lung function in young adults

High-sensitive C-reactive protein is associated with reduced lung function in young adults

Periodontitis is related to lung volumes and airflow limitation: a cross-sectional study

Endocrine regulation of airway contractility is overlooked

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