Plasma Fibrinogen Activity in Pregnancy

Gillman, Theodore; Naidoo, Strinivasen; Hathorn, M.

doi:10.1016/s0140-6736(59)90536-7

Cited by 66 publications

(10 citation statements)

References 15 publications

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“…This observation has been confirmed by other reports. [10][11][12][13][14][15][16][17] Turnover studies have shown that this increase in fibrinogen level is the result of increased synthesis by the liver. 16 We also noted a progressive rise in factor VIII activities (factor VIII:C, ristocetin cofactor, and vWFAg), especially in the second and third trimesters, and this agrees with findings from earlier reports.…”

Section: Discussionmentioning

confidence: 99%

Hemostasis in Pregnant Saudi Women

et al. 1990

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A cross-sectional study of various hemostatic variables was undertaken in women during the three trimesters of normal pregnancy. In the third trimester of pregnancy, there was significant elevation of plasma fibrinogen, 55%; factor VIII activities, 64%; factor VIII:ristocetin cofactor, 44% ; factor VIII-related antigen, 49% ; factor X, 9% ; and plasminogen, 19%, and a reduction of antithrombin III, 10%; alpha2-antiplasmin, 7%; and platelet count, 20%, compared with those values obtained in healthy nonpregnant controls. These fluctuations developed gradually during the first and second trimesters. Prothrombin time, partial thromboplastin time, thrombin time, and reptilase time were similar in pregnant women and nonpregnant controls. Platelet aggregation in response to adenosine diphosphate, collagen, adrenaline, and arachidonic acid was significantly reduced in pregnant women compared to controls. The reduced platelet aggregability in Saudi pregnant women may counterbalance the increased plasmatic coagulation potential, thereby minimizing the risk of thromboembolic disease during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Hemostasis in Pregnant Saudi Women

et al. 1990

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“…The response of plasminogen to estrogen was of particular interest in light of its increase (25), the increase in fibrinogen during pregnancy (26), and the continued concern about potential thromboembolic complications of estrogen therapy (14,27). Since plasminogen is primarily responsible for the lysis of fibrin, its apparent increase in conditions associated with increased fibrinogen may be of physiological significance.…”

Section: Discussionmentioning

confidence: 99%

Estrogen Dosage Effects on Serum Proteins: A Longitudinal Study

Doe

Mellinger

Swaim

et al. 1967

The Journal of Clinical Endocrinology & Metabolism

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A longitudinal study was made in a single individual of the effects of 5 increasing doses of diethylstilbestrol, alternated with periods of no treatment, on the concentration of serum sialic acid, haptoglobin, /3-glucuronidase, thyroxine-binding globulin, ceruloplasmin, plasminogen, corticosteroid-binding globulin, and 17-hydroxycorticosteroids. Except for sialic acid and haptoglobin, all these substances reacted with the same pattern of increase during treatment and return toward pretreatment control values during the periods off treatment. The responses of corticosteroid-binding globulin and 17-hydroxycorticosteroids were most closely dose related and were closely correlated with r = +0.91. They were responsive to a dosage of 0.1 mg/day of diethylstilbestrol.

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“…Die fibrinolytische Plasm aaktivität jedes Organismus unterliegt täglichen Schwankungen [17]; außerdem ändert sie sich bei den Frauen während des Zyklus [26] sowie im Zusammenhang m it der Schwan gerschaft [6, 11, 13, lß ], der Geburt und dem W ochenbett [4,6,13,18,19], Die fibrinolytische Plasm aaktivität ist während der Schwanger schaft bedeutend gesenkt. Das Gerinnsel des unverdünnten Plasmas weist nur Spuren einer Fibrinolyse auf [13,18,19]; die fibrinolytische A ktivität des verdünnten Plasmas ist vielfach niedriger als bei Nicht schwangeren [6], Gillman u. M itarb.…”

Section: üBersicht üBer Das Schrifttumunclassified

“…Das Gerinnsel des unverdünnten Plasmas weist nur Spuren einer Fibrinolyse auf [13,18,19]; die fibrinolytische A ktivität des verdünnten Plasmas ist vielfach niedriger als bei Nicht schwangeren [6], Gillman u. M itarb. [13] haben die Fibrinolysezeit des Euglobulins in der normalen Schwangerschaft von der 13. Woche an bis an deren Ende sowie während der Geburt und dem W ochen bett gemessen und eine Verlängerung der Fibrinolysezeit bei Schwan geren sowie eine Verkürzung zur Zeit der Geburt und im W ochenbett festgestellt.…”

Section: üBersicht üBer Das Schrifttumunclassified