Plasma fentanyl concentrations in awake cats and cats undergoing anesthesia and ovariohysterectomy using transdermal administration

Egger, Christine; Glerum, Leigh E.; Allen, Sheila W.; M, Haag

doi:10.1046/j.1467-2995.2003.00109.x

Cited by 47 publications

(39 citation statements)

References 29 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5,35 Although in our study the transdermal fentanyl patch was applied at the time of anesthetic induction, according to the total pain scores recorded, analgesia postoperatively was similar between groups. 5,35 Although in our study the transdermal fentanyl patch was applied at the time of anesthetic induction, according to the total pain scores recorded, analgesia postoperatively was similar between groups.…”

Section: Discussionmentioning

confidence: 68%

See 1 more Smart Citation

Comparison between meloxicam and transdermally administered fentanyl for treatment of postoperative pain in dogs undergoing osteotomy of the tibia and fibula and placement of a uniplanar external distraction device

Lafuente¹,

Franch²,

Durall³

et al. 2005

javma

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 68%

“…On the other hand, an appetite-depressant effect of transdermally administered fentanyl in dogs has been reported, 35 which may explain the high appetite assessment scores recorded in dogs receiving transdermally administered fentanyl. However, appetite was evaluated, which may assess possible gastrointestinal tract problems.…”

Section: Discussionmentioning

confidence: 99%

Comparison between meloxicam and transdermally administered fentanyl for treatment of postoperative pain in dogs undergoing osteotomy of the tibia and fibula and placement of a uniplanar external distraction device

Lafuente¹,

Franch²,

Durall³

et al. 2005

javma

View full text Add to dashboard Cite

show abstract

“…4,5 Fentanyl patches are commonly used for human analgesia and have increasingly been used off-label for veterinary applications. [6][7][8][9][10][11] The fentanyl patch has many potential applications in ovine surgical research to provide reliable, minimally invasive, extended analgesia. The analgesic effect of transdermally administered fentanyl in sheep, interanimal variability, and assessment of the antebrachium for ease and efficacy of patch application have not been published.…”

mentioning

confidence: 99%

Comparison of the analgesic properties of transdermally administered fentanyl and intramuscularly administered buprenorphine during and following experimental orthopedic surgery in sheep

Ahern

Soma²,

Boston³

et al. 2009

ajvr

View full text Add to dashboard Cite

show abstract

“…The most appropriate skin regime before patch application remains controversial. Several studies on fentanyl patches in animals have reported different methods of skin preparation including clipping, washing with soap, alcohol or water (Egger et al., 1998; Foley et al., 2001; Egger et al., 2003). According to the manufacturer, the lidocaine patch should be applied only on intact human skin (Package Insert, Neurodol ® Tissugel; IBSA), but no information on application of the patch in different animals is available.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of a Lidocaine Patch 5% in Dogs

Weiland¹,

Croubels²,

Baert³

et al. 2006

Journal of Veterinary Medicine Series A

View full text Add to dashboard Cite

Lidocaine is increasingly used in transdermal drug delivery systems for different pain conditions in human medicine whereby several pharmacokinetic studies have demonstrated minimal systemic absorption in men. In the present study, the pharmacokinetics of a lidocaine patch 5% was studied in six dogs. In the first experiment, one single lidocaine patch was applied for 12 h to the lateral side of the thorax after removing the hair either by clipping or by the application of a depilatory agent, according to a two-way crossover design. No potential adverse effects induced by the patches were observed in either group. In dogs with clipped hair, a mean peak plasma lidocaine concentration of 62.94 ng/ml was obtained after 10.67 h. In the depilatory group, a mean peak plasma concentration of 103.55 ng/ml was reached after 9.27 h. Significant differences in the AUC(0 --> infinity), C(max), k(a) and T(1/2a) were noticed between the two groups. No significant differences were found for the elimination parameters and for T(max). In the second experiment, the patches were applied for 60 h to the clipped skin in order to study the absorption kinetics after a prolonged application period. There, the mean peak lidocaine plasma concentration was 45.18 ng/ml achieved after 24 h and a final concentration of 29.37 ng/ml was obtained at 60 h. In conclusion, all dogs tolerated the transdermal lidocaine patch well. The results of this study suggest that there is an overall minimal absorption from the lidocaine patch. However, the application of a depilatory agent leads to a more rapid and increased absorption of lidocaine.

show abstract

Plasma fentanyl concentrations in awake cats and cats undergoing anesthesia and ovariohysterectomy using transdermal administration

Cited by 47 publications

References 29 publications

Comparison between meloxicam and transdermally administered fentanyl for treatment of postoperative pain in dogs undergoing osteotomy of the tibia and fibula and placement of a uniplanar external distraction device

Comparison between meloxicam and transdermally administered fentanyl for treatment of postoperative pain in dogs undergoing osteotomy of the tibia and fibula and placement of a uniplanar external distraction device

Comparison of the analgesic properties of transdermally administered fentanyl and intramuscularly administered buprenorphine during and following experimental orthopedic surgery in sheep

Pharmacokinetics of a Lidocaine Patch 5% in Dogs

Contact Info

Product

Resources

About